Actis, Marcelo

Mechanism of ubiquitin ligation and lysine prioritization by a HECT E3

Kamadurai, H. B., Qiu, Y., Deng, A., Harrison, J. S., MacDonald, C., Actis, M., Rodrigues, P., Miller, D. J., Souphron, J., Lewis, S. M., et al. (2013) · eLife

Ubiquitin and proteasome pathwaysEnzyme Structure and Function

Cited by 165

NALP3 inflammasome upregulation and CASP1 cleavage of the glucocorticoid receptor cause glucocorticoid resistance in leukemia cells

Paugh, S. W., Bonten, E. J., Savic, D., Ramsey, L. B., Thierfelder, W. E., Gurung, P., Malireddi, R. K. S., Actis, M., Mayasundari, A., Min, J., et al. (2015) · Nature Genetics

Acute Lymphoblastic Leukemia researchInflammasome and immune disorders

Cited by 164

Identification of the first small-molecule inhibitor of the REV7 DNA repair protein interaction

Actis, M. L., Ambaye, N. D., Evison, B. J., Shao, Y., Vanarotti, M., Inoue, A., McDonald, E. T., Kikuchi, S., Heath, R., Hara, K., et al. (2016) · Bioorganic & Medicinal Chemistry

DNA Repair MechanismsMetal complexes synthesis and properties

Cited by 42

Small-molecules that bind to the ubiquitin-binding motif of REV1 inhibit REV1 interaction with K164-monoubiquitinated PCNA and suppress DNA damage tolerance

Vanarotti, M., Evison, B. J., Actis, M. L., Inoue, A., McDonald, E. T., Shao, Y., Heath, R. J., & Fujii, N. (2018) · Bioorganic & Medicinal Chemistry

DNA Repair MechanismsUbiquitin and proteasome pathways

Cited by 17