Macadam, Andrew J.

Engineering the Live-Attenuated Polio Vaccine to Prevent Reversion to Virulence

Yeh, M. T., Bujaki, E., Dolan, P. T., Smith, M., Wahid, R., Konz, J., Weiner, A. J., Bandyopadhyay, A. S., Van Damme, P., De Coster, I., et al. (2020) · Cell Host & Microbe

Viral Infections and Immunology ResearchVirology and Viral Diseases

Cited by 221

The safety and immunogenicity of two novel live attenuated monovalent (serotype 2) oral poliovirus vaccines in healthy adults: a double-blind, single-centre phase 1 study

Van Damme, P., De Coster, I., Bandyopadhyay, A. S., Revets, H., Withanage, K., De Smedt, P., Suykens, L., Oberste, M. S., Weldon, W. C., Costa-Clemens, S. A., et al. (2019) · The Lancet

Viral Infections and Immunology ResearchVirology and Viral Diseases

Cited by 141

Genetic basis of attenuation of the Sabin type-2 vaccine strain of poliovirus in primates.

Macadam, A. J., Pollard, S. R., Ferguson, G., Skuce, R., Wood, D., Almond, J. W., & Minor, P. D. (1993) · Virology

Viral Infections and Immunology ResearchVirology and Viral Diseases

Cited by 139

The Evolutionary Pathway to Virulence of an RNA Virus

Stern, A., Yeh, M. T., Zinger, T., Smith, M., Wright, C., Ling, G., Nielsen, R., Macadam, A., & Andino, R. (2017) · Cell

Evolution and Genetic DynamicsViral Infections and Immunology Research

Cited by 127

Reversion of the attenuated and temperature-sensitive phenotypes of the sabin type 3 strain of poliovirus in vaccinees

Macadam, A. J., Arnold, C., Howlett, J., John, A., Marsden, S., Taffs, F., Reeve, P., Hamada, N., Wareham, K., Almond, J., et al. (1989) · Virology

Viral Infections and Immunology ResearchVirology and Viral Diseases

Cited by 125

Plant-made polio type 3 stabilized VLPs-a candidate synthetic polio vaccine

Marsian, J., Fox, H., Bahar, M. W., Kotecha, A., Fry, E. E., Stuart, D. I., Macadam, A. J., Rowlands, D. J., & Lomonossoff, G. P. (2017) · Nature Communications

Transgenic Plants and ApplicationsViral Infections and Immunology Research

Cited by 121

Transmission networks and population turnover of echovirus 30

Leitch, E. C. M., Bendig, J., Cabrerizo, M., Cardosa, J., Hyypiä, T., Ivanova, O. E., Kelly, A., Kroes, A. C. M., Lukashev, A., MacAdam, A., et al. (2009) · Journal of Virology

Evolution and Genetic DynamicsViral Infections and Immunology Research

Cited by 109

Rational design of genetically stable, live-attenuated poliovirus vaccines of all three serotypes: Relevance to poliomyelitis eradication

Macadam, A. J., Ferguson, G., Stone, D. M., Meredith, J., Knowlson, S., Auda, G., Almond, J. W., & Minor, P. D. (2006) · Journal of Virology

Viral Infections and Immunology ResearchVirology and Viral Diseases

Cited by 89

Evolution of the Sabin type 1 poliovirus in humans: characterization of strains isolated from patients with vaccine-associated paralytic poliomyelitis

Georgescu, M. M., Balanant, J., Macadam, A., Otelea, D., Combiescu, M., Combiescu, A. A., Crainic, R., & Delpeyroux, F. (1997) · Journal of Virology

Viral Infections and Immunology ResearchVirology and Viral Diseases

Cited by 83

Correlation of RNA secondary structure and attenuation of Sabin vaccine strains of poliovirus in tissue culture

Macadam, A. J., Ferguson, G., Burlison, J., Stone, D., Skuce, R., Almond, J. W., & Minor, P. D. (1992) · Virology

RNA and protein synthesis mechanismsViral Infections and Immunology Research

Cited by 71

The 5′ noncoding region and virulence of poliovirus vaccine strains

Macadam, A. J., Stone, D. M., Almond, J. W., & Minor, P. D. (1994) · Trends in Microbiology

Viral Infections and Immunology ResearchRNA and protein synthesis mechanisms

Cited by 44

Mammalian expression of virus-like particles as a proof of principle for next generation polio vaccines

Bahar, M. W., Porta, C., Fox, H., Macadam, A. J., Fry, E. E., & Stuart, D. I. (2021) · npj Vaccines

Viral Infectious Diseases and Gene Expression in InsectsViral Infections and Immunology Research

Cited by 42

Coding changes in the poliovirus protease 2A compensate for 5’NCR domain V disruptions in a cell-specific manner

Rowe, A., Ferguson, G. L., Minor, P. D., & Macadam, A. J. (2000) · Virology

Viral Infections and Immunology ResearchEvolution and Genetic Dynamics

Cited by 24