Multani, Asha S.

Trp53R172H and KrasG12D cooperate to promote chromosomal instability and widely metastatic pancreatic ductal adenocarcinoma in mice

Hingorani, S. R., Wang, L., Multani, A. S., Combs, C., Deramaudt, T. B., Hruban, R. H., Rustgi, A. K., Chang, S., & Tuveson, D. A. (2005) · Cancer Cell

Pancreatic and Hepatic Oncology ResearchCancer Genomics and Diagnostics

Cited by 2,609

Clonal evolution in breast cancer revealed by single nucleus genome sequencing

Wang, Y., Waters, J., Leung, M. L., Unruh, A., Roh, W., Shi, X., Chen, K., Scheet, P., Vattathil, S., Liang, H., et al. (2014) · Nature

Cancer Genomics and DiagnosticsSingle-cell and spatial transcriptomics

Cited by 1,029

Essential role of limiting telomeres in the pathogenesis of Werner syndrome

Chang, S., Multani, A. S., Cabrera, N. G., Naylor, M. L., Laud, P., Lombard, D., Pathak, S., Guarente, L., & DePinho, R. A. (2004) · Nature Genetics

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 462

Pot1 Deficiency Initiates DNA Damage Checkpoint Activation and Aberrant Homologous Recombination at Telomeres

Wu, L., Multani, A. S., He, H., Cosme-Blanco, W., Deng, Y., Deng, J. M., Bachilo, O., Pathak, S., Tahara, H., Bailey, S. M., et al. (2006) · Cell

Telomeres, Telomerase, and SenescenceDNA Repair Mechanisms

Cited by 422

Chromosome stability, in the absence of apoptosis, is critical for suppression of tumorigenesis in Trp53 mutant mice

Liu, G., Parant, J. M., Lang, G., Chau, P., Chavez-Reyes, A., El-Naggar, A. K., Multani, A., Chang, S., & Lozano, G. (2004) · Nature Genetics

Cancer-related Molecular PathwaysMicrotubule and mitosis dynamics

Cited by 325

Breast tumours maintain a reservoir of subclonal diversity during expansion

Minussi, D. C., Nicholson, M. D., Ye, H., Davis, A., Wang, K., Baker, T., Tarabichi, M., Sei, E., Du, H., Rabbani, M., et al. (2021) · Nature

Cancer Genomics and DiagnosticsSingle-cell and spatial transcriptomics

Cited by 256

Telomere dysfunction suppresses spontaneous tumorigenesis in vivo by initiating p53‐dependent cellular senescence

Cosme‐Blanco, W., Shen, M., Lazar, A. J. F., Pathak, S., Lozano, G., Multani, A. S., & Chang, S. (2007) · The EMBO Reports

Telomeres, Telomerase, and SenescenceCancer-related Molecular Pathways

Cited by 205

Capsid-CPSF6 Interaction Licenses Nuclear HIV-1 Trafficking to Sites of Viral DNA Integration

Achuthan, V., Perreira, J. M., Sowd, G. A., Puray-Chavez, M., McDougall, W. M., Paulucci-Holthauzen, A., Wu, X., Fadel, H. J., Poeschla, E. M., Multani, A. S., et al. (2018) · Cell Host & Microbe

HIV Research and TreatmentVirus-based gene therapy research

Cited by 205

Elevated telomere-telomere recombination in WRN-deficient, telomere dysfunctional cells promotes escape from senescence and engagement of the ALT pathway

Laud, P. R., Multani, A. S., Bailey, S. M., Wu, L., Ma, J., Kingsley, C., Lebel, M., Pathak, S., DePinho, R. A., & Chang, S. (2005) · Genes & Development

Telomeres, Telomerase, and SenescenceDNA Repair Mechanisms

Cited by 190

hnRNP K is a haploinsufficient tumor suppressor that regulates proliferation and differentiation programs in hematologic malignancies

Gallardo, M., Lee, H. J., Zhang, X., Bueso-Ramos, C., Pageon, L. R., McArthur, M., Multani, A., Nazha, A., Manshouri, T., Parker-Thornburg, J., et al. (2015) · Cancer Cell

Acute Myeloid Leukemia ResearchCancer-related Molecular Pathways

Cited by 145

Telomere Dysfunction Drives Aberrant Hematopoietic Differentiation and Myelodysplastic Syndrome

Colla, S., Ong, D. S. T., Ogoti, Y., Marchesini, M., Mistry, N. A., Clise-Dwyer, K., Ang, S. A., Storti, P., Viale, A., Giuliani, N., et al. (2015) · Cancer Cell

Telomeres, Telomerase, and SenescenceAcute Myeloid Leukemia Research

Cited by 105

WRN at telomeres: implications for aging and cancer

Multani, A. S., & Chang, S. (2007) · Journal of Cell Science

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 95

Evidence that senescent human prostate epithelial cells enhance tumorigenicity: cell fusion as a potential mechanism and inhibition by p16INK4a and hTERT

Bhatia, B., Multani, A. S., Patrawala, L., Chen, X., Calhoun‐Davis, T., Zhou, J., Schroeder, L., Schneider‐Broussard, R., Shen, J., Pathak, S., et al. (2008) · International Journal of Cancer

Telomeres, Telomerase, and SenescenceProstate Cancer Treatment and Research

Cited by 47

Dolastatin-10 induces polyploidy, telomeric associations and apoptosis in a murine melanoma cell line.

Pathak, S., Multani, A. S., Ozen, M., Richardson, M. A., & Newman, R. A. (1998) · Oncology Reports

Microtubule and mitosis dynamicsTelomeres, Telomerase, and Senescence

Cited by 32