Evidence that senescent human prostate epithelial cells enhance tumorigenicity: cell fusion as a potential mechanism and inhibition by p16INK4a and hTERT

Prospective Identification of Tumorigenic Prostate Cancer Stem Cells

Collins, A. T., Berry, P. A., Hyde, C. F., Stower, M. J., & Maitland, N. J. (2005) · Cancer Research · doi:10.1158/0008-5472.can-05-2018 · Cited by 2,821 · see citing works

Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors

Campisi, J. (2005) · Cell · doi:10.1016/j.cell.2005.02.003 · Cited by 2,359 · see citing works

BRAFE600-associated senescence-like cell cycle arrest of human naevi

Michaloglou, C., Vredeveld, L. C. W., Soengas, M. S., Denoyelle, C., Kuilman, T., van der Horst, C. M. A. M., Majoor, D. M., Shay, J. W., Mooi, W. J., & Peeper, D. S. (2005) · Nature · doi:10.1038/nature03890 · Cited by 2,160 · see citing works

A gene hypermethylation profile of human cancer.

Esteller, M., Corn, P. G., Baylin, S. B., & Herman, J. G. (2001) · PubMed · Cited by 2,032 · see citing works

Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis

Chen, Z., Trotman, L. C., Shaffer, D., Lin, H.-K., Dotan, Z. A., Niki, M., Koutcher, J. A., Scher, H. I., Ludwig, T., Gerald, W., et al. (2005) · Nature · doi:10.1038/nature03918 · Cited by 1,993 · see citing works

Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints

Bartkova, J., Rezaei, N., Liontos, M., Karakaidos, P., Kletsas, D., Issaeva, N., Vassiliou, L.-V. F., Kolettas, E., Niforou, K., Zoumpourlis, V. C., et al. (2006) · Nature · doi:10.1038/nature05268 · Cited by 1,986 · see citing works

Senescent fibroblasts promote epithelial cell growth and tumorigenesis: A link between cancer and aging

Krtolica, A., Parrinello, S., Lockett, S., Desprez, P.-Y., & Campisi, J. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.211053698 · Cited by 1,730 · see citing works

Ink4a/Arf expression is a biomarker of aging

Krishnamurthy, J., Torrice, C., Ramsey, M. R., Kovalev, G. I., Al-Regaiey, K., Su, L., & Sharpless, N. E. (2004) · Journal of Clinical Investigation · doi:10.1172/jci22475 · Cited by 1,486 · see citing works

Senescence in premalignant tumours

Collado, M., Gil, J., Efeyan, A., Guerra, C., Schuhmacher, A. J., Barradas, M., Benguría, A., Zaballos, A., Flores, J. M., Barbacid, M., et al. (2005) · Nature · doi:10.1038/436642a · Cited by 1,482 · see citing works

Reversal of human cellular senescence: roles of the p53 and p16 pathways

Beauséjour, C. M., Krtolica, A., Galimi, F., Narita, M., Lowe, S. W., Yaswen, P., & Campisi, J. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg417 · Cited by 1,457 · see citing works

Oncogene-induced senescence as an initial barrier in lymphoma development

Braig, M., Lee, S., Loddenkemper, C., Rudolph, C., Peters, A. H. F. M., Schlegelberger, B., Stein, H., Dörken, B., Jenuwein, T., & Schmitt, C. A. (2005) · Nature · doi:10.1038/nature03841 · Cited by 1,220 · see citing works

Stem-cell ageing modified by the cyclin-dependent kinase inhibitor p16INK4a

Janzen, V., Forkert, R., Fleming, H. E., Saito, Y., Waring, M. T., Dombkowski, D. M., Cheng, T., DePinho, R. A., Sharpless, N. E., & Scadden, D. T. (2006) · Nature · doi:10.1038/nature05159 · Cited by 1,106 · see citing works

Cellular Senescence in Aging Primates

Herbig, U., Ferreira, M., Condel, L., Carey, D., & Sedivy, J. M. (2006) · Science · doi:10.1126/science.1122446 · Cited by 1,101 · see citing works

The Regulation of INK4/ARF in Cancer and Aging

Kim, W. Y., & Sharpless, N. E. (2006) · Cell · doi:10.1016/j.cell.2006.10.003 · Cited by 1,009 · see citing works

p16INK4a induces an age-dependent decline in islet regenerative potential

Krishnamurthy, J., Ramsey, M. R., Ligon, K. L., Torrice, C., Koh, A., Bonner-Weir, S., & Sharpless, N. E. (2006) · Nature · doi:10.1038/nature05092 · Cited by 1,003 · see citing works

Increasing p16INK4a expression decreases forebrain progenitors and neurogenesis during ageing

Molofsky, A. V., Slutsky, S. G., Joseph, N. M., He, S., Pardal, R., Krishnamurthy, J., Sharpless, N. E., & Morrison, S. J. (2006) · Nature · doi:10.1038/nature05091 · Cited by 972 · see citing works

Highly purified CD44+ prostate cancer cells from xenograft human tumors are enriched in tumorigenic and metastatic progenitor cells

Patrawala, L., Calhoun, T., Schneider‐Broussard, R., Li, H., Bhatia, B., Tang, S., Reilly, J. G., Chandra, D., Zhou, J., Claypool, K., et al. (2006) · Oncogene · doi:10.1038/sj.onc.1209327 · Cited by 969 · see citing works

Side Population Is Enriched in Tumorigenic, Stem-Like Cancer Cells, whereas ABCG2+ and ABCG2− Cancer Cells Are Similarly Tumorigenic

Patrawala, L., Calhoun, T., Schneider‐Broussard, R., Zhou, J., Claypool, K., & Tang, D. G. (2005) · Cancer Research · doi:10.1158/0008-5472.can-05-0592 · Cited by 905 · see citing works

CD133, a novel marker for human prostatic epithelial stem cells

Richardson, G. D., Robson, C. N., Lang, S., Neal, D. E., Maitland, N. J., & Collins, A. T. (2004) · Journal of Cell Science · doi:10.1242/jcs.01222 · Cited by 770 · see citing works

Secretion of vascular endothelial growth factor by primary human fibroblasts at senescence

Coppé, J.-P., Kauser, K., Campisi, J., & Beauséjour, C. M. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m603307200 · Cited by 604 · see citing works

Expression of the p16INK4a tumor suppressor versus other INK4 family members during mouse development and aging

Zindy, F., Quelle, D. E., Roussel, M. F., & Sherr, C. J. (1997) · Oncogene · doi:10.1038/sj.onc.1201178 · Cited by 574 · see citing works

Connecting Chromosomes, Crisis, and Cancer

Maser, R. S., & DePinho, R. A. (2002) · Science · doi:10.1126/science.297.5581.565 · Cited by 561 · see citing works

The Gene Expression Program of Prostate Fibroblast Senescence Modulates Neoplastic Epithelial Cell Proliferation through Paracrine Mechanisms

Bavik, C., Coleman, I., Dean, J. P., Knudsen, B., Plymate, S., & Nelson, P. S. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-1716 · Cited by 453 · see citing works

The DNA damage signaling pathway is a critical mediator of oncogene-induced senescence

Mallette, F. A., Gaumont-Leclerc, M.-F., & Ferbeyre, G. (2007) · Genes & Development · doi:10.1101/gad.1487307 · Cited by 406 · see citing works

Cellular senescence in naevi and immortalisation in melanoma: a role for p16?

Gray-Schopfer, V. C., Cheong, S. C., Chong, H., Chow, J., Moss, T., Abdel-Malek, Z. A., Marais, R., Wynford-Thomas, D., & Bennett, D. C. (2006) · British Journal of Cancer · doi:10.1038/sj.bjc.6603283 · Cited by 394 · see citing works

Identification and isolation of human prostate epithelial stem cells based on α2β1-integrin expression

Collins, A. T., Habib, F. K., Maitland, N. J., & Neal, D. E. (2001) · Journal of Cell Science · doi:10.1242/jcs.114.21.3865 · Cited by 357 · see citing works

Unveiling the Mechanisms of Cell-Cell Fusion

Chen, E. H., & Olson, E. N. (2005) · Science · doi:10.1126/science.1104799 · Cited by 355 · see citing works

PRAK Is Essential for ras-Induced Senescence and Tumor Suppression

Sun, P., Yoshizuka, N., New, L., Moser, B. A., Li, Y., Liao, R., Xie, C., Chen, J., Deng, Q., Yamout, M., et al. (2007) · Cell · doi:10.1016/j.cell.2006.11.050 · Cited by 321 · see citing works

Molecular determinants of terminal growth arrest induced in tumor cells by a chemotherapeutic agent

Chang, B.-D., Swift, M. E., Shen, M., Fang, J., Broude, E. V., & Roninson, I. B. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.012602599 · Cited by 312 · see citing works

Cellular senescence as a tumor-protection mechanism: the essential role of counting

Wright, W. E., & Shay, J. W. (2001) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(00)00163-5 · Cited by 306 · see citing works

Mesenchymal stem cell aging

Fehrer, C., & Lepperdinger, G. (2005) · Experimental Gerontology · doi:10.1016/j.exger.2005.07.006 · Cited by 269 · see citing works

hTERT associates with human telomeres and enhances genomic stability and DNA repair

Sharma, G. G., Gupta, A. K. D., Wang, H., Scherthan, H., Dhar, S., Gandhi, V. V., Iliakis, G. E., Shay, J. W., Young, C. S. H., & Pandita, T. K. (2003) · Oncogene · doi:10.1038/sj.onc.1206063 · Cited by 254 · see citing works

Lack of Replicative Senescence in Cultured Rat Oligodendrocyte Precursor Cells

Tang, D. G., Tokumoto, Y. M., Apperly, J. A., Lloyd, A. C., & RAFF, M. C. (2001) · Science · doi:10.1126/science.1056780 · Cited by 228 · see citing works

Prostate cancer stem/progenitor cells: Identification, characterization, and implications

Tang, D. G., Patrawala, L., Calhoun, T., Bhatia, B., Choy, G. S., Schneider‐Broussard, R., & Jeter, C. R. (2006) · Molecular Carcinogenesis · doi:10.1002/mc.20255 · Cited by 223 · see citing works

Cell–cell interaction in prostate gene regulation and cytodifferentiation

Liu, A. Y. C., True, L. D., LaTray, L., Nelson, P. S., Ellis, W. J., Vessella, R. L., Lange, P. H., Hood, L., & van den Engh, G. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.20.10705 · Cited by 202 · see citing works

Expression of senescence-associated beta-galactosidase in enlarged prostates from men with benign prostatic hyperplasia

Choi, J. J., Shendrik, I., Peacocke, M., Peehl, D. M., Buttyan, R. E., Ikeguchi, E. F., Katz, A. E., & Benson, M. C. (2000) · Urology · doi:10.1016/s0090-4295(00)00538-0 · Cited by 173 · see citing works

Demonstration of Intermediate Cells during Human Prostate Epithelial Differentiation In Situ and In Vitro Using Triple-Staining Confocal Scanning Microscopy

van Leenders, G., Dijkman, H. B. P. M., de Kaa, C. H., Ruiter, D. J., & Schalken, J. A. (2000) · Laboratory Investigation · doi:10.1038/labinvest.3780133 · Cited by 169 · see citing works

Immunohistochemical survey of p16INK4A expression in normal human adult and infant tissues.

Nielsen, G. P., Stemmer-Rachamimov, A. O., Shaw, J., Roy, J. E., Koh, J., & Louis, D. N. (1999) · PubMed · Cited by 169 · see citing works

p16/pRb pathway alterations are required for bypassing senescence in human prostate epithelial cells.

Jarrard, D. F., Sarkar, S., Shi, Y., Yeager, T. R., Magrane, G., Kinoshita, H., Nassif, N., Meisner, L. F., Newton, M. A., Waldman, F. M., et al. (1999) · PubMed · Cited by 158 · see citing works

Spontaneous Fusion In Vivo Between Normal Host and Tumor Cells: Possible Contribution to Tumor Progression and Metastasis Studied with a Lectin-Resistant Mutant Tumor

Kerbel, R. S., Lagarde, A., Dennis, J. W., & Donaghue, T. P. (1983) · Molecular and Cellular Biology · doi:10.1128/mcb.3.4.523 · Cited by 150 · see citing works

Cellular senescence in the pathogenesis of benign prostatic hyperplasia

Castro, P. D., Giri, D., Lamb, D. J., & Ittmann, M. (2003) · The Prostate · doi:10.1002/pros.10204 · Cited by 148 · see citing works

Cellular Mechanisms for Low-Dose Ionizing Radiation–Induced Perturbation of the Breast Tissue Microenvironment

Tsai, K. K. C., Chuang, E. Y.-Y., Little, J. B., & Yuan, Z.-M. (2005) · Cancer Research · doi:10.1158/0008-5472.can-05-0703 · Cited by 145 · see citing works

p16INK4a Prevents Centrosome Dysfunction and Genomic Instability in Primary Cells

McDermott, K. M., Zhang, J., Holst, C. R., Kozakiewicz, B. K., Singla, V., & Tlsty, T. D. (2006) · PLoS Biology · doi:10.1371/journal.pbio.0040051 · Cited by 124 · see citing works

Evidence That Arachidonate 15-Lipoxygenase 2 Is a Negative Cell Cycle Regulator in Normal Prostate Epithelial Cells

Tang, S., Bhatia, B., Maldonado, C. J., Yang, P., Newman, R. A., Liu, J., Chandra, D., Traag, J., Klein, R. D., Fischer, S. M., et al. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m111936200 · Cited by 124 · see citing works

CXCL12 overexpression and secretion by aging fibroblasts enhance human prostate epithelial proliferation in vitro

Begley, L., Monteleon, C. L., Shah, R. B., MacDonald, J. W., & Macoska, J. A. (2005) · Aging Cell · doi:10.1111/j.1474-9726.2005.00173.x · Cited by 123 · see citing works

Extended survivability of prostate cancer cells in the absence of trophic factors: increased proliferation, evasion of apoptosis, and the role of apoptosis proteins.

Tang, D. G., Li, L., Chopra, D. P., & Porter, A. T. (1998) · PubMed · Cited by 110 · see citing works

Novel method for the isolation and characterisation of the putative prostatic stem cell

Bhatt, R. I., Brown, M. D., Hart, C. A., Gilmore, P. E., Ramani, V. A. C., George, N. J. R., & Clarke, N. W. (2003) · Cytometry Part A · doi:10.1002/cyto.a.10058 · Cited by 107 · see citing works

Bax-dependent Regulation of Bak by Voltage-dependent Anion Channel 2

Chandra, D., Choy, G. S., Daniel, P. T., & Tang, D. G. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m501391200 · Cited by 101 · see citing works

Subpopulations of MCF7 cells separated by Percoll gradient centrifugation: a model to analyze the heterogeneity of human breast cancer.

Resnicoff, M., Medrano, E. E., Podhajcer, O. L., Bravo, A., Bover, L. C., & Mordoh, J. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.20.7295 · Cited by 81 · see citing works

p16INK4A mediates cyclin dependent kinase 4 and 6 inhibition in senescent prostatic epithelial cells.

Sandhu, C., Peehl, D. M., & Slingerland, J. M. (2000) · PubMed · Cited by 74 · see citing works

Subcellular Localization and Tumor-suppressive Functions of 15-Lipoxygenase 2 (15-LOX2) and Its Splice Variants

Bhatia, B., Maldonado, C. J., Tang, S., Chandra, D., Klein, R. D., Chopra, D. P., Shappell, S. B., Yang, P., Newman, R. A., & Tang, D. G. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m301920200 · Cited by 66 · see citing works

Cellular Memory and Hematopoietic Stem Cell Aging

Kamminga, L. M., & de Haan, G. (2006) · Stem Cells · doi:10.1634/stemcells.2005-0345 · Cited by 62 · see citing works

Cell-autonomous induction of functional tumor suppressor 15-lipoxygenase 2 (15-LOX2) contributes to replicative senescence of human prostate progenitor cells

Bhatia, B., Tang, S., Yang, P., Doll, A., Aumüller, G., Newman, R. A., & Tang, D. G. (2005) · Oncogene · doi:10.1038/sj.onc.1208406 · Cited by 51 · see citing works

Synchronized prostate cancer cells for studying androgen regulated events in cell cycle progression from G1 into S phase

Cifuentes-Pagano, E., Croxen, R. L., Menon, M., Barrack, E. R., & Reddy, G. P. (2003) · Journal of Cellular Physiology · doi:10.1002/jcp.10317 · Cited by 34 · see citing works

Evidence that Sp1 positively and Sp3 negatively regulate and androgen does not directly regulate functional tumor suppressor 15-lipoxygenase 2 (15-LOX2) gene expression in normal human prostate epithelial cells

Tang, S., Bhatia, B., Zhou, J., Maldonado, C. J., Chandra, D., Kim, E., Fischer, S. M., Butler, A. P., Friedman, S. L., & Tang, D. G. (2004) · Oncogene · doi:10.1038/sj.onc.1207913 · Cited by 28 · see citing works

Four faces of cellular senescence

Rodier, F., & Campisi, J. (2011) · Journal of Cell Biology · doi:10.1083/jcb.201009094 · Cited by 2,016 · see citing works

The p53 network: cellular and systemic DNA damage responses in aging and Cancer

Reinhardt, H. C., & Schumacher, B. (2012) · Trends in Genetics · doi:10.1016/j.tig.2011.12.002 · Cited by 458 · see citing works

Senescence-associated IL-6 and IL-8 cytokines induce a self- and cross-reinforced senescence/inflammatory milieu strengthening tumorigenic capabilities in the MCF-7 breast cancer cell line

Ortiz-Montero, P., Londoño-Vallejo, A., & Vernot, J.-P. (2017) · Cell Communication and Signaling · doi:10.1186/s12964-017-0172-3 · Cited by 428 · see citing works

A Senescence-Inflammatory Switch from Cancer-Inhibitory to Cancer-Promoting Mechanism

Pribluda, A., Elyada, E., Wiener, Z., Hamza, H., Goldstein, R. E., Biton, M., Burstain, I., Morgenstern, Y., Brachya, G., Billauer, H., et al. (2013) · Cancer Cell · doi:10.1016/j.ccr.2013.06.005 · Cited by 239 · see citing works

PC3 human prostate carcinoma cell holoclones contain self-renewing tumor-initiating cells.

Li, H.-W., Chen, X., Calhoun-Davis, T., Claypool, K., & Tang, D. G. (2008) · Cancer Research · doi:10.1158/0008-5472.can-07-5878 · Cited by 247 · see citing works

SASP: Tumor Suppressor or Promoter? Yes!

Rao, S. G., & Jackson, J. G. (2016) · Trends in Cancer · doi:10.1016/j.trecan.2016.10.001 · Cited by 206 · see citing works

p53 and the Carcinogenicity of Chronic InflammationPreprint

Gudkov, A. V., & Komarova, E. A. (2016) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a026161 · Cited by 122 · see citing works

Understanding and targeting prostate cancer cell heterogeneity and plasticity

Tang, D. G. (2021) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2021.11.001 · Cited by 102 · see citing works

Die hard: Are cancer stem cells the Bruce Willises of tumor biology?

Fábián, Á., Barok, M., Vereb, G., & Szöllõsi, J. (2008) · Cytometry Part A · doi:10.1002/cyto.a.20690 · Cited by 92 · see citing works

Dormant cancer cells: programmed quiescence, senescence, or both?

Truskowski, K., Amend, S. R., & Pienta, K. J. (2023) · Cancer and Metastasis Reviews · doi:10.1007/s10555-022-10073-z · Cited by 79 · see citing works

Reactive oxygen species promotes cellular senescence in normal human epidermal keratinocytes through epigenetic regulation of p16INK4a

Sasaki, M., Kajiya, H., Ozeki, S., Okabe, K., & Ikebe, T. (2014) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2014.08.123 · Cited by 67 · see citing works

Doxorubicin-induced senescence in normal fibroblasts promotes in vitro tumour cell growth and invasiveness: The role of Quercetin in modulating these processes

Bientinesi, E., Lulli, M., Becatti, M., Ristori, S., Margheri, F., & Monti, D. (2022) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2022.111689 · Cited by 61 · see citing works

Senescence and cancer: An evolving inflammatory paradox

Ruhland, M. K., Coussens, L. M., & Stewart, S. A. (2015) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2015.10.001 · Cited by 60 · see citing works

p53 Isoforms in Cellular Senescence- and Ageing-Associated Biological and Physiological Functions

Fujita, K. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20236023 · Cited by 57 · see citing works

Fibroblasts as Turned Agents in Cancer Progression

Wieder, R. (2023) · Cancers · doi:10.3390/cancers15072014 · Cited by 54 · see citing works

Tumor Microenvironment and Cell Fusion

Jiang, E., Yan, T., Xu, Z., & Shang, Z. (2019) · BioMed Research International · doi:10.1155/2019/5013592 · Cited by 49 · see citing works

Cell Fusion of Mesenchymal Stem/Stromal Cells and Breast Cancer Cells Leads to the Formation of Hybrid Cells Exhibiting Diverse and Individual (Stem Cell) Characteristics

Dörnen, J., Myklebost, O., & Dittmar, T. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21249636 · Cited by 36 · see citing works

Critical and Distinct Roles of p16 and Telomerase in Regulating the Proliferative Life Span of Normal Human Prostate Epithelial Progenitor Cells*

Bhatia, B., Jiang, M., Suraneni, M. V., Patrawala, L., Badeaux, M. D., Schneider‐Broussard, R., Multani, A., Jeter, C. R., Calhoun-Davis, T., Hu, L., et al. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m803467200 · Cited by 36 · see citing works

Could stroma contribute to field cancerization?

Ge, L., Meng, W., Zhou, H., & Bhowmick, N. A. (2010) · Medical Hypotheses · doi:10.1016/j.mehy.2010.01.019 · Cited by 34 · see citing works

Cellular Senescence Triggers Altered Circadian Clocks With a Prolonged Period and Delayed Phases

Ahmed, R., Nakahata, Y., Shinohara, K., & Bessho, Y. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.638122 · Cited by 32 · see citing works

Human pituitary tumor-transforming gene 1 overexpression reinforces oncogene-induced senescence through CXCR2/p21 signaling in breast cancer cells

Ruan, J., Liao, Y., Lua, I., Li, M.-H., Hsu, C.-Y., & Chen, J. H. (2012) · Breast Cancer Research · doi:10.1186/bcr3226 · Cited by 30 · see citing works

Tumor-suppressive functions of 15-Lipoxygenase-2 and RB1CC1 in prostate cancer

Suraneni, M. V., Moore, J., Zhang, D., Badeaux, M. D., Macaluso, M. D., DiGiovanni, J., Kusewitt, D. F., & Tang, D. G. (2014) · Cell Cycle · doi:10.4161/cc.28757 · Cited by 28 · see citing works

Leukemia-Induced Cellular Senescence and Stemness Alterations in Mesenchymal Stem Cells Are Reversible upon Withdrawal of B-Cell Acute Lymphoblastic Leukemia Cells

Vanegas, N.-D. P., Ruiz-Aparicio, P. F., Uribe, G. I., Ballesteros, A. L., & Vernot, J. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22158166 · Cited by 26 · see citing works

The inflammatory network: bridging senescent stroma and epithelial tumorigenesis

Shan, W. (2009) · Frontiers in bioscience · doi:10.2741/3511 · Cited by 26 · see citing works

Combining an Aurora Kinase Inhibitor and a Death Receptor Ligand/Agonist Antibody Triggers Apoptosis in Melanoma Cells and Prevents Tumor Growth in Preclinical Mouse Models

Liu, Y., Hawkins, O. E., Vilgelm, A. E., Pawlikowski, J. S., Ecsedy, J., Sosman, J. A., Kelley, M. C., & Richmond, A. J. (2015) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-15-0293 · Cited by 25 · see citing works

Notch and Senescence

Hoare, M., & Narita, M. (2018) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-89512-3_15 · Cited by 23 · see citing works

Loss of p16: A Bouncer of the Immunological Surveillance?

Leon, K. E., Tangudu, N. K., Aird, K. M., & Buj, R. (2021) · Life · doi:10.3390/life11040309 · Cited by 19 · see citing works

Cell‑cell fusion as an important mechanism of tumor metastasis (Review)

Peng, X., Zhang, M., Meng, Y., Liang, Y.-F., Wang, Y., Liu, X., Cai, W.-Q., Zhou, Y., Wang, X.-W., Ma, Z., et al. (2021) · Oncology Reports · doi:10.3892/or.2021.8096 · Cited by 17 · see citing works

The Potential Role of Senescence As a Modulator of Platelets and Tumorigenesis

Valenzuela, C. A., Quintanilla, R., Moore‐Carrasco, R., & Brown, N. E. (2017) · Frontiers in Oncology · doi:10.3389/fonc.2017.00188 · Cited by 17 · see citing works

Dissociated Primary Human Prostate Cancer Cells Coinjected with the Immortalized Hs5 Bone Marrow Stromal Cells Generate Undifferentiated Tumors in NOD/SCID-γ Mice

Chen, X., Liu, B., Li, Q., Honorio, S., Liu, X., Liu, C., Multani, A. S., Calhoun‐Davis, T., & Tang, D. G. (2013) · PLoS ONE · doi:10.1371/journal.pone.0056903 · Cited by 14 · see citing works

Comparison of hybrid clones derived from human breast epithelial cells and three different cancer cell lines regarding in vitro cancer stem/ initiating cell properties

Fahlbusch, S. S., Keil, S., Epplen, J. T., Zänker, K. S., & Dittmar, T. (2020) · BMC Cancer · doi:10.1186/s12885-020-06952-9 · Cited by 14 · see citing works

CD95 ligand induces senescence in mismatch repair-deficient human colon cancer via chronic caspase-mediated induction of DNA damage

Raats, D., Frenkel, N. C., van Schelven, S. J., Rinkes, I. H. M. B., Laoukili, J., & Kranenburg, O. (2017) · Cell Death and Disease · doi:10.1038/cddis.2017.87 · Cited by 14 · see citing works

ROS-degradable hydrogel delivering LOXL2-LNPs rescues disc degeneration by synchronously suppressing cellular senescence and oxidative damage

Zhang, J., Li, Y., Ding, R., Pan, C., Xie, J., Huang, G., Chen, X., Zhao, X., Miao, X., & Cheng, X. (2025) · Journal of Nanobiotechnology · doi:10.1186/s12951-025-03718-y · Cited by 9 · see citing works

Synthetic circuits based on split Cas9 to detect cellular events

Przybyszewska-Podstawka, A., Czapiński, J., Kałafut, J., & Rivero‐Müller, A. (2023) · Scientific Reports · doi:10.1038/s41598-023-41367-z · Cited by 8 · see citing works

Abnormal differentiation, hyperplasia and embryonic/perinatal lethality in BK5-T/t transgenic mice

Chen, X., Schneider‐Broussard, R., Hollowell, D., McArthur, M. J., Jeter, C. R., Benavides, F. J., DiGiovanni, J., & Tang, D. G. (2009) · Differentiation · doi:10.1016/j.diff.2008.10.011 · Cited by 4 · see citing works

Research and experimental verification on the mechanisms of cellular senescence in triple-negative breast cancer

Cao, T., Huang, M., Huang, X., & Tang, T. (2024) · PeerJ · doi:10.7717/peerj.16935 · Cited by 3 · see citing works

Search for genes – potential markers of aggressiveness and metastasis for human prostate cancer

Rosenberg, E. E., Prudnikova, T. Y., Gerashchenko, G. V., Витальевна, Г. Э., & Kashuba, V. I. (2013) · Biopolymers and Cell · doi:10.7124/bc.000840 · Cited by 3 · see citing works

Blocking the Notch Pathway with Gamma-Secretase Inhibitors Enhances Temozolomide Treatment of Gliomas through Therapy-Induced Senescence: A Dissertation

Gilbert, C. A. (2011) · eScholarship@UMassChan · doi:10.13028/a7fz-f103 · Cited by 1 · see citing works

Complex Interactions Between Osteosarcoma Cells and Fibroblasts

David, M. S. (2011) · The Sydney eScholarship Repository (The University of Sydney)

Interaktionsmuster von Gliomzellen, Gliomendothelzellen und humanen mesenchymalen Stammzellen

Korte, B. G. (2012) · doi:10.5282/edoc.13934

Étude de l’activité des présumés IRES de l’ARN messager de p53

Cadar, A. E. (2014) · doi:10.71781/31878

Die Rolle der Zellfusion im Tumorkontext. Fakt oder Fiktion?

Dittmar, T. (2019) · Deutsche Zeitschrift für Onkologie · doi:10.1055/a-0759-4761

Papel de la proteína quinasa C (PKC) en el crecimiento de células de leucemia linfoide aguda tipo B, en el soporte que les proporcionan las células stem mesenquimales y en su funcionalidad en un modelo in vitro de nicho leucémico

Avendaño, V., & Pilar, N.-D. (2021)

Renoprotective effects of DAPT against zymosan-induced acute kidney injury and senescence: Unraveling the role of toll like receptor 2 and Notch1 signaling pathways through an integrated in vivo and in silico analysis

Safwat, M. H., El‐Aleam, R. H. A., Rashad, E., El-Tanbouly, D. M., Ibrahim, S. M., & Fathy, N. F. S. (2026) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2026.178803

Le génome remanié comme oncogène des sarcomes pléomorphes ?

Delespaul, L. (2018) · theses.fr (ABES) · doi:10.70675/12f3b234zd503z4d00za731z88e607a39433

Impact of aging on cardiac mesenchymal stromal cells

Martini, H. (2019) · theses.fr (ABES) · doi:10.70675/bb7ddcb3z0b6az4c39za6eczc94e0563f0a3

Spontaneous Cell Fusion as the Mechanism of Cancer Progression and Metastasis

Ruoxiang, W. (2026) · iMed · doi:10.70322/imed.2026.10004

Critical and Distinct Roles of p16 and Telomerase in Regulating the Proliferative Life Span of Normal Human Prostate Epithelial Progenitor Cells*

Bhatia, B., Jiang, M., Suraneni, M. V., Patrawala, L., Badeaux, M. D., Schneider‐Broussard, R., Multani, A., Jeter, C. R., Calhoun-Davis, T., Hu, L., et al. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m803467200 · Cited by 36 · see citing works

Cellular senescence suppresses prostate tumorigenesis in mice

Osborne, T. (2005) · Nature Clinical Practice Urology · doi:10.1038/ncpuro0283

A novel type of cellular senescence that can be enhanced in mouse models and human tumor xenografts to suppress prostate tumorigenesis

Alimonti, A., Nardella, C., Chen, Z., Clohessy, J. G., Carracedo, A., Trotman, L. C., Cheng, K., Varmeh, S., Kozma, S. C., Thomas, G., et al. (2010) · Journal of Clinical Investigation · doi:10.1172/jci40535 · Cited by 374 · see citing works

Function of JunB in transient amplifying cell senescence and progression of human prostate cancer.

Konishi, N., Shimada, K., Nakamura, M., Ishida, E., Ota, I., Tanaka, N., & Fujimoto, K. (2008) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-07-4120 · Cited by 46 · see citing works

Abstract A028: Dissecting the role of cellular senescence in prostate cancer initiation and immune suppression

Zhou, L., Snyder, J. T., Murphy, K. C., DeMarco, K. D., Chana, S. K., Simin, K. J., Jiang, Z., & Ruscetti, M. A. (2023) · Cancer Research · doi:10.1158/1538-7445.prca2023-a028 · Cited by 1 · see citing works