Redmond, T. Michael

Safety and Efficacy of Gene Transfer for Leber's Congenital Amaurosis

Maguire, A. M., Simonelli, F., Pierce, E. A., Pugh, E. N., Mingozzi, F., Bennicelli, J., Banfi, S., Marshall, K. A., Testa, F., Surace, E. M., et al. (2008) · New England Journal of Medicine

Retinal Development and DisordersVirus-based gene therapy research

Cited by 2,145

Age-dependent effects of RPE65 gene therapy for Leber's congenital amaurosis: a phase 1 dose-escalation trial

Maguire, A. M., High, K. A., Auricchio, A., Wright, J. F., Pierce, E. A., Testa, F., Mingozzi, F., Bennicelli, J. L., Ying, G.-S., Rossi, S., et al. (2009) · The Lancet

Retinal Development and DisordersVirus-based gene therapy research

Cited by 865

Mutations in RPE65 cause Leber's congenital amaurosis

Marlhens, F., Bareil, C., Griffoin, J.-M., Zrenner, E., Amalric, P., Eliaou, C., Liu, S.-Y., Harris, E., Redmond, T. M., Arnaud, B., et al. (1997) · Nature Genetics

Retinal Development and DisordersRetinal Diseases and Treatments

Cited by 606

Mutation of key residues of RPE65 abolishes its enzymatic role as isomerohydrolase in the visual cycle

Redmond, T. M., Poliakov, E., Yu, S., Tsai, J.-Y., Lu, Z., & Gentleman, S. (2005) · Proceedings of the National Academy of Sciences

Retinal Development and DisordersRetinoids in leukemia and cellular processes

Cited by 409

Functional and structural recovery of the retina after gene therapy in the RPE65 null mutation dog

Narfstro¨m, K., Katz, M. L., Bragadottir, R., Seeliger, M., Boulanger, A., Redmond, T. M., Caro, L., Lai, C.-M., & Rakoczy, P. E. (2003) · Investigative Opthalmology & Visual Science

Retinal Development and DisordersVirus-based gene therapy research

Cited by 252

Expression of ABCA4 in the retinal pigment epithelium and its implications for Stargardt macular degeneration

Lenis, T. L., Hu, J., Ng, S. Y., Jiang, Z., Sarfare, S., Lloyd, M. B., Esposito, N. J., Samuel, W., Jaworski, C., Bok, D., et al. (2018) · Proceedings of the National Academy of Sciences

Retinal Development and DisordersRetinal Diseases and Treatments

Cited by 158

Cone Opsin Mislocalization in Rpe65−/−Mice: A Defect That Can Be Corrected by 11-cis Retinal

Rohrer, B., Lohr, H. R., Humphries, P., Redmond, T. M., Seeliger, M. W., & Crouch, R. K. (2005) · Investigative Opthalmology & Visual Science

Retinal Development and DisordersRetinal Diseases and Treatments

Cited by 133

RPE65 Is an Iron(II)-dependent Isomerohydrolase in the Retinoid Visual Cycle

Moiseyev, G., Takahashi, Y., Chen, Y., Gentleman, S., Redmond, T. M., Crouch, R. K., & Ma, J.-X. (2006) · Journal of Biological Chemistry

Retinal Development and DisordersRetinoids in leukemia and cellular processes

Cited by 119

Retinyl Esters Are the Substrate for Isomerohydrolase

Moiseyev, G., Crouch, R. K., Goletz, P., Oatis, Redmond, T. M., & Ma, J.-X. (2003) · Biochemistry

Retinal Development and DisordersRetinoids in leukemia and cellular processes

Cited by 116

RPE65, Visual Cycle Retinol Isomerase, Is Not Inherently 11-cis-specific

Redmond, T. M., Poliakov, E., Kuo, S., Chander, P., & Gentleman, S. (2010) · Journal of Biological Chemistry

Retinal Development and DisordersPhotoreceptor and optogenetics research

Cited by 65

Resveratrol attenuates CXCL11 expression induced by proinflammatory cytokines in retinal pigment epithelial cells

Kutty, R. K., Samuel, W., Abay, R., Cherukuri, A., Nagineni, C. N., Duncan, T., Jaworski, C., Vijayasarathy, C., & Redmond, T. M. (2015) · Cytokine

Retinal Diseases and TreatmentsSirtuins and Resveratrol in Medicine

Cited by 31

Aromatic Residues in the Substrate Cleft of RPE65 Protein Govern Retinol Isomerization and Modulate Its Progression

Chander, P., Gentleman, S., Poliakov, E., & Redmond, T. M. (2012) · Journal of Biological Chemistry

Retinal Development and DisordersRetinoids in leukemia and cellular processes

Cited by 19

Aromatic Lipophilic Spin Traps Effectively Inhibit RPE65 Isomerohydrolase Activity

Poliakov, E., Parikh, T., Ayele, M., Kuo, S., Chander, P., Gentleman, S., & Redmond, T. M. (2011) · Biochemistry

Electron Spin Resonance StudiesRetinal Development and Disorders

Cited by 18

RPE65 takes on another role in the vertebrate retina

Redmond, T. M. (2017) · Proceedings of the National Academy of Sciences

Retinal Development and DisordersRetinal Diseases and Treatments

Cited by 7