Resveratrol attenuates CXCL11 expression induced by proinflammatory cytokines in retinal pigment epithelial cells
Open accessAbstract
Dysfunction of the retinal pigment epithelium (RPE) resulting from chronic inflammation is implicated in the pathogenesis of age-related macular degeneration (AMD). RPE cells adjacent to drusen deposits in the AMD eye are known to contain CXCL11, a chemokine involved in inflammatory cell recruitment. We investigated the CXCL11 production by the human RPE (ARPE-19) cells under inflammatory conditions and tested its response to resveratrol, a naturally occurring anti-inflammatory antioxidant. A proinflammatory cytokine mixture consisting of IFN-γ, IL-1β and TNF-α highly increased CXCL11 mRNA expression and CXCL11 protein secretion by ARPE-19 cells. Resveratrol substantially inhibited the proinflammatory cytokines-induced CXCL11 production while partially blocking nuclear factor-κB activation. This inhibitory action of resveratrol was also observed for the cytokines-induced expression of chemokines CXCL9, CCL2 and CCL5. Our results indicate that resveratrol could potentially attenuate RPE inflammatory response implicated in the pathogenesis of AMD.
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Upregulation of CXCL11 is seen in RPE cells adjacent to drusen deposits in AMD.
“Upregulation of CXCL11 is seen in RPE cells adjacent to drusen deposits in AMD [62], and its secretion can be triggered by proinflammatory cytokines including TNF and IL-1β.”
From Fecal microbiota transfer between young and aged mice reverses hallmarks of the aging gut, eye, and brain (2022) · cites this paper as [62]
CXCL11 secretion can be triggered by proinflammatory cytokines including TNF and IL-1β.
“Upregulation of CXCL11 is seen in RPE cells adjacent to drusen deposits in AMD [62], and its secretion can be triggered by proinflammatory cytokines including TNF and IL-1β.”
From Fecal microbiota transfer between young and aged mice reverses hallmarks of the aging gut, eye, and brain (2022) · cites this paper as [62]
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- Authors
- Kutty, R. K., Samuel, W., Abay, R., Cherukuri, A., Nagineni, C. N., Duncan, T., Jaworski, C., Vijayasarathy, C., & Redmond, T. M.
- Affiliations
- National Institutes of Health (US)
- Corresponding author
- Kutty, R. Krishnan
- Venue
- Cytokine
- Publisher
- Elsevier BV
- Published
- 2015-08
- Volume
- 74
- Issue
- 2
- Pages
- 335-338
- ISSN
- 1043-4666 (ISSN-L)
- PMC
- PMC4475468
- OpenAlex
- W2067131208
- Cited by
- 31
- References
- 15
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 4 · 2023: 2 · 2022: 7 · 2021: 3 · 2020: 3 · 2019: 1 · 2018: 2 · 2017: 3 · 2016: 4
- FWCI
- 2.89
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Cytokine (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Eye Institute
- NIH
- Topics
- Health Sciences › Medicine › Ophthalmology › Retinal Diseases and Treatments
- Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
- Health Sciences › Medicine › Ophthalmology › Ocular Diseases and Behçet’s Syndrome
- Keywords
- resveratrol, CXCL11, retinal pigment epithelium, age-related macular degeneration, inflammatory cytokines, chemokine expression, NF-κB activation, ARPE-19 cells, drusen, anti-inflammatory activity
- MeSH terms
- Resveratrol, Cell Line, Gene Expression Regulation, Humans, Inflammation, Stilbenes, NF-kappa B, Chemokine CXCL11, Retinal Pigment Epithelium
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