Thapar, Vishal

GUIDE-seq enables genome-wide profiling of off-target cleavage by CRISPR-Cas nucleases

Tsai, S. Q., Zheng, Z., Nguyen, N. T., Liebers, M., Topkar, V. V., Thapar, V., Wyvekens, N., Khayter, C., Iafrate, A. J., Le, L. P., et al. (2015) · Nature Biotechnology

CRISPR and Genetic EngineeringRNA regulation and disease

Cited by 2,268

Dimeric CRISPR RNA-guided FokI nucleases for highly specific genome editing

Tsai, S. Q., Wyvekens, N., Khayter, C., Foden, J. A., Thapar, V., Reyon, D., Goodwin, M. J., Aryee, M. J., & Joung, J. K. (2014) · Nature Biotechnology

CRISPR and Genetic EngineeringRNA regulation and disease

Cited by 952

Non-Cell-Autonomous Tumor Suppression by p53

Lujambio, A., Akkari, L., Simon, J., Grace, D., Tschaharganeh, D. F., Bolden, J. E., Zhao, Z., Thapar, V., Joyce, J. A., Krizhanovsky, V., et al. (2013) · Cell

Telomeres, Telomerase, and SenescenceCancer-related Molecular Pathways

Cited by 766

BRD4 Connects Enhancer Remodeling to Senescence Immune Surveillance

Tasdemir, N., Banito, A., Roe, J.-S., Alonso-Curbelo, D., Camiolo, M., Tschaharganeh, D. F., Huang, C.-H., Aksoy, O., Bolden, J. E., Chen, C.-C., et al. (2016) · Cancer Discovery

Telomeres, Telomerase, and SenescenceGenomics and Chromatin Dynamics

Cited by 415

Temporal and spatial heterogeneity of host response to SARS-CoV-2 pulmonary infection

Desai, N., Neyaz, A., Szabolcs, A., Shih, A. R., Chen, J. H., Thapar, V., Nieman, L. T., Solovyov, A., Mehta, A., Lieb, D. J., et al. (2020) · Nature Communications

SARS-CoV-2 and COVID-19 ResearchCOVID-19 Clinical Research Studies

Cited by 245

Epithelial to mesenchymal plasticity and differential response to therapies in pancreatic ductal adenocarcinoma

Porter, R. L., Magnus, N. K. C., Thapar, V., Morris, R., Szabolcs, A., Neyaz, A., Kulkarni, A. S., Tai, E., Chougule, A., Hillis, A., et al. (2019) · Proceedings of the National Academy of Sciences

Pancreatic and Hepatic Oncology ResearchCancer Cells and Metastasis

Cited by 129

Development of siRNA Payloads to Target KRAS -Mutant Cancer

Yuan, T. L., Fellmann, C., Lee, C.-S., Ritchie, C. D., Thapar, V., Lee, L. C., Hsu, D. J., Grace, D., Carver, J. O., Zuber, J., et al. (2014) · Cancer Discovery

RNA Interference and Gene DeliveryRNA Research and Splicing

Cited by 113

Reverse Transcriptase Inhibition Disrupts Repeat Element Life Cycle in Colorectal Cancer.

Rajurkar, M., Parikh, A. R., Solovyov, A., You, E., Kulkarni, A. S., Chu, C., Xu, K. H., Jaicks, C., Taylor, M. S., Wu, C., et al. (2022) · Cancer Discovery

Chromosomal and Genetic VariationsCancer-related molecular mechanisms research

Cited by 61

Satellite repeat RNA expression in epithelial ovarian cancer associates with a tumor-immunosuppressive phenotype

Porter, R. L., Sun, S., Flores, M. N., Berzolla, E., You, E., Phillips, I. E., KC, N., Desai, N., Tai, E. C., Szabolcs, A., et al. (2022) · Journal of Clinical Investigation

Cancer-related molecular mechanisms researchOvarian cancer diagnosis and treatment

Cited by 24