Fujii, Naoaki

Mechanism of ubiquitin ligation and lysine prioritization by a HECT E3

Kamadurai, H. B., Qiu, Y., Deng, A., Harrison, J. S., MacDonald, C., Actis, M., Rodrigues, P., Miller, D. J., Souphron, J., Lewis, S. M., et al. (2013) · eLife

Ubiquitin and proteasome pathwaysEnzyme Structure and Function

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Stearoyl-CoA desaturase promotes liver fibrosis and tumor development in mice via a wnt positive-signaling loop by stabilization of low-density lipoprotein-receptor-related proteins 5 and 6

Lai, K. K. Y., Kweon, S.-M., Chi, F., Hwang, E., Kabe, Y., Higashiyama, R., Qin, L., Yan, R., Wu, R. P., Lai, K., et al. (2017) · Gastroenterology

Wnt/β-catenin signaling in development and cancerLiver physiology and pathology

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Identification of small molecule proliferating cell nuclear antigen (PCNA) inhibitor that disrupts interactions with PIP-box proteins and inhibits DNA replication

Punchihewa, C., Inoue, A., Hishiki, A., Fujikawa, Y., Connelly, M., Evison, B., Shao, Y., Heath, R., Kuraoka, I., Rodrigues, P., et al. (2012) · Journal of Biological Chemistry

DNA Repair MechanismsDNA and Nucleic Acid Chemistry

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Identification of the first small-molecule inhibitor of the REV7 DNA repair protein interaction

Actis, M. L., Ambaye, N. D., Evison, B. J., Shao, Y., Vanarotti, M., Inoue, A., McDonald, E. T., Kikuchi, S., Heath, R., Hara, K., et al. (2016) · Bioorganic & Medicinal Chemistry

DNA Repair MechanismsMetal complexes synthesis and properties

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Small-molecules that bind to the ubiquitin-binding motif of REV1 inhibit REV1 interaction with K164-monoubiquitinated PCNA and suppress DNA damage tolerance

Vanarotti, M., Evison, B. J., Actis, M. L., Inoue, A., McDonald, E. T., Shao, Y., Heath, R. J., & Fujii, N. (2018) · Bioorganic & Medicinal Chemistry

DNA Repair MechanismsUbiquitin and proteasome pathways

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