Harney, John W.

Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation

Watanabe, M., Houten, S. M., Mataki, C., Christoffolete, M. A., Kim, B. W., Sato, H., Messaddeq, N., Harney, J. W., Ezaki, O., Kodama, T., et al. (2006) · Nature

Adipose Tissue and MetabolismDrug Transport and Resistance Mechanisms

Cited by 2,220

Severe hypothyroidism caused by type 3 iodothyronine deiodinase in infantile hemangiomas

Huang, S. A., Tu, H. M., Harney, J. W., Venihaki, M., Butte, A. J., Kozakewich, H. P. W., Fishman, S. J., & Larsen, P. R. (2000) · New England Journal of Medicine

Thyroid Disorders and TreatmentsVascular Malformations and Hemangiomas

Cited by 540

Molecular biological and biochemical characterization of the human type 2 selenodeiodinase.

Salvatore, D., Bartha, T., Harney, J. W., & Larsen, P. R. (1996) · Endocrinology

Thyroid Disorders and TreatmentsSelenium in Biological Systems

Cited by 284

The Hedgehog-inducible ubiquitin ligase subunit WSB-1 modulates thyroid hormone activation and PTHrP secretion in the developing growth plate

Dentice, M., Bandyopadhyay, A., Gereben, B., Callebaut, I., Christoffolete, M. A., Kim, B. W., Nissim, S., Mornon, J.-P., Zavacki, A. M., Zeöld, A., et al. (2005) · Nature Cell Biology

Hedgehog Signaling Pathway StudiesUbiquitin and proteasome pathways

Cited by 227

Type 2 iodothyronine deiodinase is highly expressed in human thyroid.

Salvatore, D., Tu, H., Harney, J. W., & Larsen, P. R. (1996) · Journal of Clinical Investigation

Thyroid Disorders and TreatmentsThyroid Cancer Diagnosis and Treatment

Cited by 196

Lipopolysaccharide Induces Type 2 Iodothyronine Deiodinase in the Mediobasal Hypothalamus: Implications for the Nonthyroidal Illness Syndrome

Fekete, C., Gereben, B., Doleschall, M., Harney, J. W., Dora, J. M., Bianco, A. C., Sarkar, S., Liposits, Z., Rand, W., Emerson, C., et al. (2004) · Endocrinology

Thyroid Disorders and TreatmentsNeuropeptides and Animal Physiology

Cited by 179

Selective Proteolysis of Human Type 2 Deiodinase: A Novel Ubiquitin-Proteasomal Mediated Mechanism for Regulation of Hormone Activation

Gereben, B., Goncalves, C., Harney, J. W., Larsen, P. R., & Bianco, A. C. (2000) · Molecular Endocrinology

Thyroid Disorders and TreatmentsUbiquitin and proteasome pathways

Cited by 161

A novel retinoid X receptor-independent thyroid hormone response element is present in the human type 1 deiodinase gene

Toyoda, N., Zavacki, A. M., Maia, A. L., Harney, J. W., & Larsen, P. R. (1995) · Molecular and Cellular Biology

Thyroid Disorders and TreatmentsEstrogen and related hormone effects

Cited by 142

Type 1 iodothyronine deiodinase is a sensitive marker of peripheral thyroid status in the mouse

Zavacki, A. M., Ying, H., Christoffolete, M. A., Aerts, G., So, E., Harney, J. W., Cheng, S.-Y., Larsen, P. R., & Bianco, A. C. (2005) · Endocrinology

Thyroid Disorders and TreatmentsEstrogen and related hormone effects

Cited by 138

Selective Inhibition of Selenocysteine tRNA Maturation and Selenoprotein Synthesis in Transgenic Mice Expressing Isopentenyladenosine-Deficient Selenocysteine tRNA

Moustafa, M. E., Carlson, B. A., El-Saadani, M. A., Kryukov, G. V., Sun, Q.-A., Harney, J. W., Hill, K. E., Combs, G. F., Feigenbaum, L., Mansur, D. B., et al. (2001) · Molecular and Cellular Biology

Selenium in Biological SystemsRNA and protein synthesis mechanisms

Cited by 131

Agouti-related protein (AGRP) has a central inhibitory action on the hypothalamic-pituitary-thyroid (HPT) axis; comparisons between the effect of AGRP and neuropeptide Y on energy homeostasis and the HPT axis

Fekete, C., Sarkar, S., Rand, W. M., Harney, J. W., Emerson, C. H., Bianco, A. C., & Lechan, R. M. (2002) · Endocrinology

Regulation of Appetite and ObesityNeuropeptides and Animal Physiology

Cited by 131

Characterization of the 5′-Flanking and 5′-Untranslated Regions of the Cyclic Adenosine 3′,5′-Monophosphate-Responsive Human Type 2 Iodothyronine Deiodinase Gene1

Bartha, T., Kim, S.-W., Salvatore, D., Gereben, B., Tu, H. M., Harney, J. W., Rudas, P., & Larsen, P. R. (2000) · Endocrinology

Thyroid Disorders and TreatmentsThyroid Cancer Diagnosis and Treatment

Cited by 118

Atypical Expression of Type 2 Iodothyronine Deiodinase in Thyrotrophs Explains the Thyroxine-Mediated Pituitary Thyrotropin Feedback Mechanism

Christoffolete, M. A., Ribeiro, R., Singru, P., Fekete, C., da Silva, W. S., Gordon, D. F., Huang, S. A., Crescenzi, A., Harney, J. W., Ridgway, E. C., et al. (2006) · Endocrinology

Thyroid Disorders and TreatmentsGrowth Hormone and Insulin-like Growth Factors

Cited by 118

Substrate-Induced Down-Regulation of Human Type 2 Deiodinase (hD2) Is Mediated through Proteasomal Degradation and Requires Interaction with the Enzyme’s Active Center1

Steinsapir, J., Bianco, A. C., Buettner, C., Harney, J., & Larsen, P. R. (2000) · Endocrinology

Thyroid Disorders and TreatmentsUbiquitin and proteasome pathways

Cited by 109

Ubiquitination-induced conformational change within the deiodinase dimer is a switch regulating enzyme activity

Sagar, G. D. V., Gereben, B., Callebaut, I., Mornon, J.-P., Zeöld, A., da Silva, W. S., Luongo, C., Dentice, M., Tente, S. M., Freitas, B. C. G., et al. (2007) · Molecular and Cellular Biology

Ubiquitin and proteasome pathwaysThyroid Disorders and Treatments

Cited by 103

Type 2 iodothyronine deiodinase in rat pituitary tumor cells is inactivated in proteasomes

Steinsapir, J., Harney, J., & Larsen, P. R. (1998) · Journal of Clinical Investigation

Thyroid Disorders and TreatmentsUbiquitin and proteasome pathways

Cited by 102

Studies of the Hormonal Regulation of Type 2 5′-Iodothyronine Deiodinase Messenger Ribonucleic Acid in Pituitary Tumor Cells Using Semiquantitative Reverse Transcription-Polymerase Chain Reaction**This work was supported by NIH Grant DK-36256.

Kim, S.-W., Harney, J. W., & Larsen, P. R. (1998) · Endocrinology

Thyroid Disorders and TreatmentsGrowth Hormone and Insulin-like Growth Factors

Cited by 86

Regional physiological adaptation of the central nervous system deiodinases to iodine deficiency

Peeters, R., Fekete, C., Goncalves, C., Legradi, G., Tu, H. M., Harney, J. W., Bianco, A. C., Lechan, R. M., & Larsen, P. R. (2001) · American Journal of Physiology-Endocrinology and Metabolism

Thyroid Disorders and TreatmentsChemical Analysis and Environmental Impact

Cited by 79

Neuropeptide Y1 and Y5 Receptors Mediate the Effects of Neuropeptide Y on the Hypothalamic-Pituitary-Thyroid Axis

Fekete, C., Sarkar, S., Rand, W. M., Harney, J. W., Emerson, C. H., Bianco, A. C., Beck-Sickinger, A., & Lechan, R. M. (2002) · Endocrinology

Neuropeptides and Animal PhysiologyRegulation of Appetite and Obesity

Cited by 79

Further Characterization of Thyroid Hormone Response Elements in the Human Type 1 Iodothyronine Deiodinase Gene1

Zhang, C.-Y., Kim, S., Harney, J. W., & Larsen, P. R. (1998) · Endocrinology

Thyroid Disorders and TreatmentsEstrogen and related hormone effects

Cited by 72

The human, but not rat, dio2 gene is stimulated by thyroid transcription factor-1 (TTF-1)

Gereben, B., Salvatore, D., Harney, J. W., Tu, H. M., & Larsen, P. R. (2001) · Molecular Endocrinology

Thyroid Disorders and TreatmentsThyroid Cancer Diagnosis and Treatment

Cited by 70

Thyroxine-induced expression of pyroglutamyl peptidase II and inhibition of TSH release precedes suppression of TRH mRNA and requires type 2 deiodinase

Marsili, A., Sanchez, E., Singru, P., Harney, J. W., Zavacki, A. M., Lechan, R. M., & Larsen, P. R. (2011) · Journal of Endocrinology

Thyroid Disorders and TreatmentsNeuropeptides and Animal Physiology

Cited by 27