Kuriyan, John

An allosteric mechanism for activation of the kinase domain of epidermal growth factor receptor

Zhang, X., Gureasko, J., Shen, K., Cole, P. A., & Kuriyan, J. (2006) · Cell

HER2/EGFR in Cancer ResearchProtein Kinase Regulation and GTPase Signaling

Cited by 1,650

The structural basis of the activation of Ras by Sos

Boriack-Sjodin, P. A., Margarit, S. M., Bar-Sagi, D., & Kuriyan, J. (1998) · Nature

Protein Kinase Regulation and GTPase SignalingReceptor Mechanisms and Signaling

Cited by 799

Inhibition of the EGF receptor by binding of MIG6 to an activating kinase domain interface

Zhang, X., Pickin, K. A., Bose, R., Jura, N., Cole, P. A., & Kuriyan, J. (2007) · Nature

HER2/EGFR in Cancer ResearchProtein Kinase Regulation and GTPase Signaling

Cited by 357

Structural analysis of the catalytically inactive kinase domain of the human EGF receptor 3

Jura, N., Shan, Y., Cao, X., Shaw, D. E., & Kuriyan, J. (2009) · Proceedings of the National Academy of Sciences

HER2/EGFR in Cancer ResearchProtein Kinase Regulation and GTPase Signaling

Cited by 338

Structure of the Autoinhibited Kinase Domain of CaMKII and SAXS Analysis of the Holoenzyme

Rosenberg, O. S., Deindl, S., Sung, R.-J., Nairn, A. C., & Kuriyan, J. (2005) · Cell

Protein Kinase Regulation and GTPase SignalingProtein Structure and Dynamics

Cited by 333

Catalytic Control in the EGF Receptor and Its Connection to General Kinase Regulatory Mechanisms

Jura, N., Zhang, X., Endres, N. F., Seeliger, M. A., Schindler, T., & Kuriyan, J. (2011) · Molecular Cell

Protein Kinase Regulation and GTPase SignalingProtein Structure and Dynamics

Cited by 310

DNA binding of in vitro activated Stat1 alpha, Stat1 beta and truncated Stat1: interaction between NH2‐terminal domains stabilizes binding of two dimers to tandem DNA sites.

Vinkemeier, U., Cohen, S. L., Moarefi, I., Chait, B. T., Kuriyan, J., & Darnell, J. E. (1996) · The EMBO Journal

Cytokine Signaling Pathways and Interactionsinterferon and immune responses

Cited by 308

Prospective discovery of small molecule enhancers of an E3 ligase-substrate interaction

Simonetta, K. R., Taygerly, J., Boyle, K., Basham, S. E., Padovani, C., Lou, Y., Cummins, T. J., Yung, S. L., von Soly, S. K., Kayser, F., et al. (2019) · Nature Communications

Protein Degradation and InhibitorsUbiquitin and proteasome pathways

Cited by 217

Ras activation by SOS: Allosteric regulation by altered fluctuation dynamics

Iversen, L., Tu, H.-L., Lin, W.-C., Christensen, S. M., Abel, S. M., Iwig, J., Wu, H.-J., Gureasko, J., Rhodes, C., Petit, R. S., et al. (2014) · Science

Protein Kinase Regulation and GTPase SignalingCellular transport and secretion

Cited by 154

Structural basis and regulation of the reductive stress response

Manford, A. G., Mena, E. L., Shih, K. Y., Gee, C. L., McMinimy, R., Martínez-González, B., Sherriff, R., Lew, B., Zoltek, M., Rodríguez-Pérez, F., et al. (2021) · Cell

Ubiquitin and proteasome pathwaysRedox biology and oxidative stress

Cited by 152

Intersubunit capture of regulatory segments is a component of cooperative CaMKII activation

Chao, L. H., Pellicena, P., Deindl, S., Barclay, L. A., Schulman, H., & Kuriyan, J. (2010) · Nature Structural & Molecular Biology

Protein Kinase Regulation and GTPase SignalingSignaling Pathways in Disease

Cited by 119

Deconstruction of the Ras switching cycle through saturation mutagenesis

Bandaru, P., Shah, N. H., Bhattacharyya, M., Barton, J. P., Kondo, Y., Cofsky, J. C., Gee, C. L., Chakraborty, A. K., Kortemme, T., Ranganathan, R., et al. (2017) · eLife

Protein Kinase Regulation and GTPase SignalingEvolution and Genetic Dynamics

Cited by 117

Activation-triggered subunit exchange between CaMKII holoenzymes facilitates the spread of kinase activity

Stratton, M., Lee, I.-H., Bhattacharyya, M., Christensen, S. M., Chao, L. H., Schulman, H., Groves, J. T., & Kuriyan, J. (2014) · eLife

Protein Kinase Regulation and GTPase SignalingNeuroscience and Neuropharmacology Research

Cited by 114

Molecular mechanism of activation-triggered subunit exchange in Ca2+/calmodulin-dependent protein kinase II

Bhattacharyya, M., Stratton, M. M., Going, C. C., McSpadden, E. D., Huang, Y., Susa, A. C., Elleman, A., Cao, Y. M., Pappireddi, N., Burkhardt, P., et al. (2016) · eLife

Protein Kinase Regulation and GTPase SignalingProtein Structure and Dynamics

Cited by 112

Structural Insights into the Regulation of Ca2+/Calmodulin-Dependent Protein Kinase II (CaMKII)

Bhattacharyya, M., Karandur, D., & Kuriyan, J. (2020) · Cold Spring Harbor Perspectives in Biology

Protein Kinase Regulation and GTPase SignalingSignaling Pathways in Disease

Cited by 95

Flexible linkers in CaMKII control the balance between activating and inhibitory autophosphorylation

Bhattacharyya, M., Lee, Y. K., Muratcioglu, S., Qiu, B., Nyayapati, P., Schulman, H., Groves, J. T., & Kuriyan, J. (2020) · eLife

Protein Kinase Regulation and GTPase SignalingNeuroscience and Neuropharmacology Research

Cited by 58

Breakage of the oligomeric CaMKII hub by the regulatory segment of the kinase

Karandur, D., Bhattacharyya, M., Xia, Z., Lee, Y. K., Muratcioglu, S., McAffee, D., McSpadden, E. D., Qiu, B., Groves, J. T., Williams, E. R., et al. (2020) · eLife

Protein Kinase Regulation and GTPase SignalingProtein Structure and Dynamics

Cited by 35