Dachs, Gabi U.

Hypoxia-inducible factor-1 modulates gene expression in solid tumors and influences both angiogenesis and tumor growth

Maxwell, P. H., Dachs, G. U., Gleadle, J. M., Nicholls, L. G., Harris, A. L., Stratford, I. J., Hankinson, O., Pugh, C. W., & Ratcliffe, P. J. (1997) · Proceedings of the National Academy of Sciences

Cancer, Hypoxia, and MetabolismAngiogenesis and VEGF in Cancer

Cited by 1,084

Low Ascorbate Levels Are Associated with Increased Hypoxia-Inducible Factor-1 Activity and an Aggressive Tumor Phenotype in Endometrial Cancer

Kuiper, C., Molenaar, I. G. M., Dachs, G. U., Currie, M. J., Sykes, P. H., & Vissers, M. C. M. (2010) · Cancer Research

Cancer, Hypoxia, and MetabolismVitamin C and Antioxidants Research

Cited by 135

Modulation of hypoxia-inducible factor-1 alpha in cultured primary cells by intracellular ascorbate

Vissers, M. C. M., Gunningham, S. P., Morrison, M. J., Dachs, G. U., & Currie, M. J. (2007) · Free Radical Biology and Medicine

Cancer, Hypoxia, and MetabolismVitamin C and Antioxidants Research

Cited by 125

Intracellular ascorbate enhances hypoxia-inducible factor (HIF)-hydroxylase activity and preferentially suppresses the HIF-1 transcriptional response

Kuiper, C., Dachs, G. U., Currie, M. J., & Vissers, M. C. M. (2014) · Free Radical Biology and Medicine

Cancer, Hypoxia, and MetabolismVitamin C and Antioxidants Research

Cited by 117

Association of angiopoietin-2, C-reactive protein and markers of obesity and insulin resistance with survival outcome in colorectal cancer.

Volkova, E., Willis, J. A., Wells, J. E., Robinson, B. A., Dachs, G. U., & Currie, M. J. (2011) · British Journal of Cancer

Inflammatory Biomarkers in Disease PrognosisAdipokines, Inflammation, and Metabolic Diseases

Cited by 78

Pharmacokinetic and anti-cancer properties of high dose ascorbate in solid tumours of ascorbate-dependent mice

Campbell, E. J., Vissers, M. C. M., Wohlrab, C., Hicks, K. O., Strother, R. M., Bozonet, S. M., Robinson, B. A., & Dachs, G. U. (2016) · Free Radical Biology and Medicine

Vitamin C and Antioxidants ResearchCancer, Hypoxia, and Metabolism

Cited by 67

Activation of the hypoxia pathway in breast cancer tissue and patient survival are inversely associated with tumor ascorbate levels

Campbell, E. J., Dachs, G. U., Morrin, H. R., Davey, V. C., Robinson, B. A., & Vissers, M. C. M. (2019) · BMC Cancer

Cancer, Hypoxia, and MetabolismVitamin C and Antioxidants Research

Cited by 63

Restoring physiological levels of ascorbate slows tumor growth and moderates HIF‐1 pathway activity in Gulo−/− mice

Campbell, E. J., Vissers, M. C. M., Bozonet, S., Dyer, A., Robinson, B. A., & Dachs, G. U. (2015) · Cancer Medicine

Vitamin C and Antioxidants ResearchCancer, Hypoxia, and Metabolism

Cited by 59

The Association Between Ascorbate and the Hypoxia-Inducible Factors in Human Renal Cell Carcinoma Requires a Functional Von Hippel-Lindau Protein

Wohlrab, C., Vissers, M. C. M., Phillips, E., Morrin, H., Robinson, B. A., & Dachs, G. U. (2018) · Frontiers in Oncology

Cancer, Hypoxia, and MetabolismRenal cell carcinoma treatment

Cited by 35

Regulation of the 2-oxoglutarate-dependent dioxygenases and implications for cancer

Vissers, M. C. M., Kuiper, C., & Dachs, G. U. (2014) · Biochemical Society Transactions

Cancer, Hypoxia, and MetabolismMetal-Catalyzed Oxygenation Mechanisms

Cited by 32