Suematsu, Makoto

CD44 Variant Regulates Redox Status in Cancer Cells by Stabilizing the xCT Subunit of System xc− and Thereby Promotes Tumor Growth

Ishimoto, T., Nagano, O., Yae, T., Tamada, M., Motohara, T., Oshima, H., Oshima, M., Ikeda, T., Asaba, R., Yagi, H., et al. (2011) · Cancer Cell

Redox biology and oxidative stressSulfur Compounds in Biology

Cited by 1,192

A defined commensal consortium elicits CD8 T cells and anti-cancer immunity

Tanoue, T., Morita, S., Plichta, D. R., Skelly, A. N., Suda, W., Sugiura, Y., Narushima, S., Vlamakis, H., Motoo, I., Sugita, K., et al. (2019) · Nature

Gut microbiota and healthT-cell and B-cell Immunology

Cited by 1,145

Reactive cysteine persulfides and S-polythiolation regulate oxidative stress and redox signaling

Ida, T., Sawa, T., Ihara, H., Tsuchiya, Y., Watanabe, Y., Kumagai, Y., Suematsu, M., Motohashi, H., Fujii, S., Matsunaga, T., et al. (2014) · Proceedings of the National Academy of Sciences

Sulfur Compounds in BiologyRedox biology and oxidative stress

Cited by 934

Regulation of the HIF-1α Level Is Essential for Hematopoietic Stem Cells

Takubo, K., Goda, N., Yamada, W., Iriuchishima, H., Ikeda, E., Kubota, Y., Shima, H., Johnson, R. S., Hirao, A., Suematsu, M., et al. (2010) · Cell Stem Cell

Hematopoietic Stem Cell TransplantationCancer, Hypoxia, and Metabolism

Cited by 891

Novel bile acid biosynthetic pathways are enriched in the microbiome of centenarians

Sato, Y., Atarashi, K., Plichta, D. R., Arai, Y., Sasajima, S., Kearney, S. M., Suda, W., Takeshita, K., Sasaki, T., Okamoto, S., et al. (2021) · Nature

Gut microbiota and healthSteroid Chemistry and Biochemistry

Cited by 632

Restoring metabolism of myeloid cells reverses cognitive decline in ageing

Minhas, P. S., Latif-Hernandez, A., McReynolds, M. R., Durairaj, A. S., Wang, Q., Rubin, A., Joshi, A. U., He, J. Q., Gauba, E., Liu, L., et al. (2021) · Nature

Neuroinflammation and Neurodegeneration MechanismsGenetics, Aging, and Longevity in Model Organisms

Cited by 526

Crosstalk between Glucocorticoid Receptor and Nutritional Sensor mTOR in Skeletal Muscle

Shimizu, N., Yoshikawa, N., Ito, N., Maruyama, T., Suzuki, Y., Takeda, S.-I., Nakae, J., Tagata, Y., Nishitani, S., Takehana, K., et al. (2011) · Cell Metabolism

Muscle Physiology and DisordersMuscle metabolism and nutrition

Cited by 498

Senolysis by glutaminolysis inhibition ameliorates various age-associated disorders

Johmura, Y., Yamanaka, T., Omori, S., Wang, T.-W., Sugiura, Y., Matsumoto, M., Suzuki, N., Kumamoto, S., Yamaguchi, K., Hatakeyama, S., et al. (2021) · Science

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 440

Inflammation, But Not Telomere Length, Predicts Successful Ageing at Extreme Old Age: A Longitudinal Study of Semi-supercentenarians

Arai, Y., Martin-Ruiz, C. M., Takayama, M., Abe, Y., Takebayashi, T., Koyasu, S., Suematsu, M., Hirose, N., & von Zglinicki, T. (2015) · EBioMedicine

Genetics, Aging, and Longevity in Model OrganismsAging and Gerontology Research

Cited by 333

Adrenocortical zonation in humans under normal and pathological conditions

Nishimoto, K., Nakagawa, K., Li, D., Kosaka, T., Oya, M., Mikami, S., Shibata, H., Itoh, H., Mitani, F., Yamazaki, T., et al. (2010) · The Journal of Clinical Endocrinology & Metabolism

Hormonal Regulation and HypertensionAdrenal Hormones and Disorders

Cited by 310

ERK and p38 MAPK, but not NF-κB, Are Critically Involved in Reactive Oxygen Species–Mediated Induction of IL-6 by Angiotensin II in Cardiac Fibroblasts

Sano, M., Fukuda, K., Sato, T., Kawaguchi, H., Suematsu, M., Matsuda, S., Koyasu, S., Matsui, H., Yamauchi-Takihara, K., Harada, M., et al. (2001) · Circulation Research

Renin-Angiotensin System StudiesCardiac Fibrosis and Remodeling

Cited by 298

Characterization of the 17 strains of regulatory T cell-inducing human-derived Clostridia

Narushima, S., Sugiura, Y., Oshima, K., Atarashi, K., Hattori, M., Suematsu, M., & Honda, K. (2014) · Gut Microbes

Gut microbiota and healthT-cell and B-cell Immunology

Cited by 210

Autophagy regulates lipid metabolism through selective turnover of NCoR1

Saito, T., Kuma, A., Sugiura, Y., Ichimura, Y., Obata, M., Kitamura, H., Okuda, S., Lee, H.-C., Ikeda, K., Kanegae, Y., et al. (2019) · Nature Communications

Autophagy in Disease and TherapyPeroxisome Proliferator-Activated Receptors

Cited by 193

Pioglitazone prevents alcohol-induced fatty liver in rats through up-regulation of c-Met

Tomita, K., Azuma, T., Kitamura, N., Nishida, J., Tamiya, G., Oka, A., Inokuchi, S., Nishimura, T., Suematsu, M., & Ishii, H. (2004) · Gastroenterology

Alcohol Consumption and Health EffectsLiver Disease Diagnosis and Treatment

Cited by 141

Generation of human adult hepatocyte organoids with metabolic functions

Igarashi, R., Oda, M., Okada, R., Yano, T., Takahashi, S., Pastuhov, S., Matano, M., Masuda, N., Togasaki, K., Ohta, Y., et al. (2025) · Nature

Liver physiology and pathologyWnt/β-catenin signaling in development and cancer

Cited by 85

HIF-1 in T cells ameliorated dextran sodium sulfate-induced murine colitis

Higashiyama, M., Hokari, R., Hozumi, H., Kurihara, C., Ueda, T., Watanabe, C., Tomita, K., Nakamura, M., Komoto, S., Okada, Y., et al. (2012) · Journal of Leukocyte Biology

Inflammatory Bowel DiseaseT-cell and B-cell Immunology

Cited by 68

Rescue of anaemia and autoimmune responses in SOD1-deficient mice by transgenic expression of human SOD1 in erythrocytes

Iuchi, Y., Okada, F., Takamiya, R., Kibe, N., Tsunoda, S., Nakajima, O., Toyoda, K., Nagae, R., Suematsu, M., Soga, T., et al. (2009) · Biochemical Journal

Redox biology and oxidative stressAntioxidant Activity and Oxidative Stress

Cited by 45

Hypoxia-inducible factor-1 is a determinant of lobular structure and oxygen consumption in the liver

Tsukada, K., Tajima, T., Hori, S., Matsuura, T., Johnson, R. S., Goda, N., & Suematsu, M. (2013) · Microcirculation

Liver physiology and pathologyCancer, Hypoxia, and Metabolism

Cited by 18

Quiescence of adult oligodendrocyte precursor cells requires thyroid hormone and hypoxia to activate Runx1

Tokumoto, Y., Tamaki, S., Kabe, Y., Takubo, K., & Suematsu, M. (2017) · Scientific Reports

Neurogenesis and neuroplasticity mechanismsGlioma Diagnosis and Treatment

Cited by 16