Steel, David

A foundation model for generalizable disease detection from retinal images

Zhou, Y., Chia, M. A., Wagner, S. K., Ayhan, M. S., Williamson, D. J., Struyven, R. R., Liu, T., Xu, M., Lozano, M. G., Woodward-Court, P., et al. (2023) · Nature

Retinal Imaging and AnalysisOphthalmology and Visual Health Research

Cited by 1,014

Efficient stage-specific differentiation of human pluripotent stem cells toward retinal photoreceptor cells

Mellough, C. B., Sernagor, E., Moreno-Gimeno, I., Steel, D. H. W., & Lako, M. (2012) · Stem Cells

Retinal Development and DisordersPluripotent Stem Cells Research

Cited by 162

An Induced Pluripotent Stem Cell Patient Specific Model of Complement Factor H (Y402H) Polymorphism Displays Characteristic Features of Age-Related Macular Degeneration and Indicates a Beneficial Role for UV Light Exposure

Hallam, D., Collin, J., Bojic, S., Chichagova, V., Buskin, A., Xu, Y., Lafage, L., Otten, E. G., Anyfantis, G., Mellough, C., et al. (2017) · Stem Cells

Retinal Diseases and TreatmentsRetinal Development and Disorders

Cited by 75

Complement modulation reverses pathology in Y402H-retinal pigment epithelium cell model of age-related macular degeneration by restoring lysosomal function

Cerniauskas, E., Kurzawa-Akanbi, M., Xie, L., Hallam, D., Moya-Molina, M., White, K., Steel, D., Doherty, M., Whitfield, P., Al-Aama, J., et al. (2020) · Stem Cells Translational Medicine

Retinal Diseases and TreatmentsComplement system in diseases

Cited by 58

Evaluation of Shared Genetic Susceptibility to High and Low Myopia and Hyperopia

Tideman, J. W. L., Pärssinen, O., Haarman, A. E. G., Khawaja, A. P., Wedenoja, J., Williams, K. M., Biino, G., Ding, X., Kähönen, M., Lehtimäki, T., et al. (2021) · JAMA Ophthalmology

Ophthalmology and Visual Impairment StudiesGenetic Associations and Epidemiology

Cited by 56

Retinal Asymmetry in Multiple Sclerosis

Petzold, A., Chua, S. Y. L., Khawaja, A. P., Keane, P. A., Khaw, P. T., Reisman, C., Dhillon, B., Strouthidis, N. G., Foster, P. J., Patel, P. J., et al. (2021) · Brain

Multiple Sclerosis Research StudiesGlaucoma and retinal disorders

Cited by 56

Bruch’s Membrane: A Key Consideration with Complement-Based Therapies for Age-Related Macular Degeneration

Hammadi, S., Tzoumas, N., Ferrara, M., Meschede, I. P., Lo, K., Harris, C., Lako, M., & Steel, D. H. (2023) · Journal of Clinical Medicine

Retinal Diseases and TreatmentsComplement system in diseases

Cited by 44

Complement inhibitors for age-related macular degeneration

Tzoumas, N., Riding, G., Williams, M. A., & Steel, D. H. (2023) · Cochrane Database of Systematic Reviews

Retinal Diseases and TreatmentsComplement system in diseases

Cited by 38

Revisiting the role of factor H in age-related macular degeneration: Insights from complement-mediated renal disease and rare genetic variants

Tzoumas, N., Hallam, D., Harris, C. L., Lako, M., Kavanagh, D., & Steel, D. H. W. (2021) · Survey of Ophthalmology

Complement system in diseasesRetinal Diseases and Treatments

Cited by 33

Sensitivity analysis in clinical trials: three criteria for a valid sensitivity analysis

Parpia, S., Morris, T. P., Phillips, M. R., Wykoff, C. C., Steel, D. H., Thabane, L., Bhandari, M., Chaudhary, V., for the Retina Evidence Trials InterNational Alliance (R.E.T.I.N.A.) Study Group, Sivaprasad, S., et al. (2022) · Eye

Statistical Methods in Clinical TrialsStatistical Methods and Bayesian Inference

Cited by 32

Rare complement factor I variants associated with reduced macular thickness and age-related macular degeneration in the UK Biobank

Tzoumas, N., Kavanagh, D., Cordell, H. J., Lotery, A. J., Patel, P. J., & Steel, D. H. (2022) · Human Molecular Genetics

Retinal Diseases and TreatmentsComplement system in diseases

Cited by 31