Harnett, William

IL-33/ST2 signalling and crosstalk with FcεRI and TLR4 is targeted by the parasitic worm product, ES-62

Ball, D. H., Al-Riyami, L., Harnett, W., & Harnett, M. M. (2018) · Scientific Reports

IL-33, ST2, and ILC PathwaysMast cells and histamine

Cited by 197

Designing Anti-inflammatory Drugs from Parasitic Worms: A Synthetic Small Molecule Analogue of the Acanthocheilonema viteae Product ES-62 Prevents Development of Collagen-Induced Arthritis

Al-Riyami, L., Pineda, M. A., Rzepecka, J., Huggan, J. K., Khalaf, A. I., Suckling, C. J., Scott, F. J., Rodgers, D. T., Harnett, M. M., & Harnett, W. (2013) · Journal of Medicinal Chemistry

Parasites and Host InteractionsHelminth infection and control

Cited by 94

Phosphorylcholine mimics the effects of ES-62 on macrophages and dendritic cells

GOODRIDGE, H. S., McGUINESS, S., HOUSTON, K. M., EGAN, C. A., AL‐RIYAMI, L., ALCOCER, M. J. C., HARNETT, M. M., & HARNETT, W. (2007) · Parasite Immunology

Parasitic Diseases Research and TreatmentParasites and Host Interactions

Cited by 89

ES-62, a therapeutic anti-inflammatory agent evolved by the filarial nematode Acanthocheilonema viteae

Pineda, M. A., Lumb, F., Harnett, M. M., & Harnett, W. (2014) · Molecular and Biochemical Parasitology

Parasites and Host InteractionsParasitic Diseases Research and Treatment

Cited by 88

Filarial nematode secreted product ES-62 is an anti-inflammatory agent: Therapeutic potential of small molecule derivatives and ES-62 peptide mimetics

Harnett, W., & Harnett, M. M. (2006) · Clinical and Experimental Pharmacology and Physiology

Parasites and Host InteractionsParasitic Diseases Research and Treatment

Cited by 56

A Filarial Nematode-Secreted Phosphorylcholine-Containing Glycoprotein Uncouples the B Cell Antigen Receptor from Extracellular Signal-Regulated Kinase-Mitogen-Activated Protein Kinase by Promoting the Surface Ig-Mediated Recruitment of Src Homology 2 Domain-Containing Tyrosine Phosphatase-1 and Pac-1 Mitogen-Activated Kinase-Phosphatase

Deehan, M. R., Harnett, W., & Harnett, M. M. (2001) · The Journal of Immunology

Parasites and Host InteractionsParasitic Diseases Research and Treatment

Cited by 42

Small molecule analogues of the immunomodulatory parasitic helminth product ES-62 have anti-allergy properties

Rzepecka, J., Coates, M. L., Saggar, M., Al-Riyami, L., Coltherd, J., Tay, H. K., Huggan, J. K., Janicova, L., Khalaf, A. I., Siebeke, I., et al. (2014) · International Journal for Parasitology

Parasites and Host InteractionsAsthma and respiratory diseases

Cited by 40

Protection against arthritis by the parasitic worm product ES-62, and its drug-like small molecule analogues, is associated with inhibition of osteoclastogenesis

Doonan, J., Lumb, F. E., Pineda, M. A., Tarafdar, A., Crowe, J., Khan, A. M., Suckling, C. J., Harnett, M. M., & Harnett, W. (2018) · Frontiers in Immunology

Parasites and Host InteractionsBone Metabolism and Diseases

Cited by 38

Synthetic analogues of the parasitic worm product ES-62 reduce disease development in in vivo models of lung fibrosis

Suckling, C. J., Mukherjee, S., Khalaf, A. I., Narayan, A., Scott, F. J., Khare, S., Dhakshinamoorthy, S., Harnett, M. M., & Harnett, W. (2018) · Acta Tropica

Parasites and Host InteractionsInterstitial Lung Diseases and Idiopathic Pulmonary Fibrosis

Cited by 12