Goodyear, Laurie J.

Role of AMP-Activated Protein Kinase in Mechanism of Metformin Action

Zhou, G., Myers, R., Li, Y., Chen, Y., Shen, X., Fenyk-Melody, J., Wu, M., Ventre, J., Doebber, T., Fujii, N., et al. (2001) · Journal of Clinical Investigation

Metabolism, Diabetes, and CancerPeroxisome Proliferator-Activated Receptors

Cited by 5,652

Free fatty acid-induced insulin resistance is associated with activation of protein kinase C theta and alterations in the insulin signaling cascade.

Griffin, M. E., Marcucci, M. J., Cline, G. W., Bell, K., Barucci, N., Lee, D., Goodyear, L. J., Kraegen, E. W., White, M. F., & Shulman, G. I. (1999) · Diabetes

Metabolism, Diabetes, and CancerDiabetes, Cardiovascular Risks, and Lipoproteins

Cited by 1,267

Brown adipose tissue regulates glucose homeostasis and insulin sensitivity

Stanford, K. I., Middelbeek, R. J. W., Townsend, K. L., An, D., Nygaard, E. B., Hitchcox, K. M., Markan, K. R., Nakano, K., Hirshman, M. F., Tseng, Y.-H., et al. (2013) · Journal of Clinical Investigation

Adipose Tissue and MetabolismAdipokines, Inflammation, and Metabolic Diseases

Cited by 1,180

Exercise, Glucose Transport, and Insulin Sensitivity

Goodyear, L. J., & Kahn, B. B. (1998) · Annual Review of Medicine

Metabolism, Diabetes, and CancerCardiovascular and exercise physiology

Cited by 1,056

Restoring systemic GDF11 levels reverses age-related dysfunction in mouse skeletal muscle

Sinha, M., Jang, Y. C., Oh, J., Khong, D., Wu, E. Y., Manohar, R., Miller, C., Regalado, S. G., Loffredo, F. S., Pancoast, J. R., et al. (2014) · Science

Muscle Physiology and DisordersTelomeres, Telomerase, and Senescence

Cited by 824

Metformin Increases AMP-Activated Protein Kinase Activity in Skeletal Muscle of Subjects With Type 2 Diabetes

Musi, N., Hirshman, M. F., Nygren, J., Svanfeldt, M., Bavenholm, P., Rooyackers, O., Zhou, G., Williamson, J. M., Ljunqvist, O., Efendic, S., et al. (2002) · Diabetes

Metabolism, Diabetes, and CancerDiabetes Treatment and Management

Cited by 806

Evidence for 5' AMP-activated protein kinase mediation of the effect of muscle contraction on glucose transport

Hayashi, T., Hirshman, M. F., Kurth, E. J., Winder, W. W., & Goodyear, L. J. (1998) · Diabetes

Metabolism, Diabetes, and CancerAdipose Tissue and Metabolism

Cited by 774

Targeted disruption of the glucose transporter 4 selectively in muscle causes insulin resistance and glucose intolerance

Zisman, A., Peroni, O. D., Abel, E. D., Michael, M. D., Mauvais-Jarvis, F., Lowell, B. B., Wojtaszewski, J. F. P., Hirshman, M. F., Virkamaki, A., Goodyear, L. J., et al. (2000) · Nature Medicine

Metabolism, Diabetes, and CancerDiabetes, Cardiovascular Risks, and Lipoproteins

Cited by 743

Ampk phosphorylation of Ulk1 is required for targeting of mitochondria to lysosomes in exercise-induced mitophagy

Laker, R. C., Drake, J. C., Wilson, R. J., Lira, V. A., Lewellen, B. M., Ryall, K. A., Fisher, C. C., Zhang, M., Saucerman, J. J., Goodyear, L. J., et al. (2017) · Nature Communications

Autophagy in Disease and TherapyMetabolism, Diabetes, and Cancer

Cited by 529

Diet and exercise signals regulate SIRT3 and activate AMPK and PGC-1α in skeletal muscle

Palacios, O. M., Carmona, J. J., Michan, S., Chen, K. Y., Manabe, Y., III, J. L. W., Goodyear, L. J., & Tong, Q. (2009) · Aging

Sirtuins and Resveratrol in MedicineAdipose Tissue and Metabolism

Cited by 487

Highly Efficient, Functional Engraftment of Skeletal Muscle Stem Cells in Dystrophic Muscles

Cerletti, M., Jurga, S., Witczak, C. A., Hirshman, M. F., Shadrach, J. L., Goodyear, L. J., & Wagers, A. J. (2008) · Cell

Muscle Physiology and DisordersNeurogenetic and Muscular Disorders Research

Cited by 472

Metabolic stress and altered glucose transport: activation of AMP-activated protein kinase as a unifying coupling mechanism.

Hayashi, T., Hirshman, M. F., Fujii, N., Habinowski, S. A., Witters, L. A., & Goodyear, L. J. (2000) · Diabetes

Metabolism, Diabetes, and CancerAdipose Tissue and Metabolism

Cited by 447

Muscle-specific PPARγ-deficient mice develop increased adiposity and insulin resistance but respond to thiazolidinediones

Norris, A. W., Chen, L., Fisher, S. J., Szanto, I., Ristow, M., Jozsi, A. C., Hirshman, M. F., Rosen, E. D., Goodyear, L. J., Gonzalez, F. J., et al. (2003) · Journal of Clinical Investigation

Peroxisome Proliferator-Activated ReceptorsAdipose Tissue and Metabolism

Cited by 417

Acute exercise induces GLUT4 translocation in skeletal muscle of normal human subjects and subjects with type 2 diabetes

Kennedy, J. W., Hirshman, M. F., Gervino, E. V., Ocel, J. V., Forse, R. A., Hoenig, S. J., Aronson, D., Goodyear, L. J., & Horton, E. S. (1999) · Diabetes

Metabolism, Diabetes, and CancerDiabetes, Cardiovascular Risks, and Lipoproteins

Cited by 415

Insulin signaling and insulin sensitivity after exercise in human skeletal muscle

Wojtaszewski, J. F., Hansen, B. F., Gade, Kiens, B., Markuns, J. F., Goodyear, L. J., & Richter, E. A. (2000) · Diabetes

Metabolism, Diabetes, and CancerMuscle metabolism and nutrition

Cited by 382

Exercise, MAPK, and NF-κB signaling in skeletal muscle

Kramer, H. F., & Goodyear, L. J. (2007) · Journal of Applied Physiology

Exercise and Physiological ResponsesMuscle Physiology and Disorders

Cited by 375

AMP-activated protein kinase (AMPK) is activated in muscle of subjects with type 2 diabetes during exercise

Musi, N., Fujii, N., Hirshman, M. F., Ekberg, I., Fröberg, S., Ljungqvist, O., Thorell, A., & Goodyear, L. J. (2001) · Diabetes

Metabolism, Diabetes, and CancerNatural Antidiabetic Agents Studies

Cited by 371

Exercise induces isoform-specific increase in 5'AMP-activated protein kinase activity in human skeletal muscle

Fujii, N., Hayashi, T., Hirshman, M. F., Smith, J. T., Habinowski, S. A., Kaijser, L., Mu, J., Ljungqvist, O., Birnbaum, M. J., Witters, L. A., et al. (2000) · Biochemical and Biophysical Research Communications

Metabolism, Diabetes, and CancerCardiovascular and exercise physiology

Cited by 351

Distinct Signals Regulate AS160 Phosphorylation in Response to Insulin, AICAR, and Contraction in Mouse Skeletal Muscle

Kramer, H. F., Witczak, C. A., Fujii, N., Jessen, N., Taylor, E. B., Arnolds, D. E., Sakamoto, K., Hirshman, M. F., & Goodyear, L. J. (2006) · Diabetes

Metabolism, Diabetes, and CancerAdipose Tissue and Metabolism

Cited by 315

Contraction signaling to glucose transport in skeletal muscle

Jessen, N., & Goodyear, L. J. (2005) · Journal of Applied Physiology

Metabolism, Diabetes, and CancerAdipose Tissue and Metabolism

Cited by 311

Signaling mechanisms in skeletal muscle: acute responses and chronic adaptations to exercise

Röckl, K. S. C., Witczak, C. A., & Goodyear, L. J. (2008) · IUBMB Life

Metabolism, Diabetes, and CancerMuscle Physiology and Disorders

Cited by 222

Reduced expression of the murine p85α subunit of phosphoinositide 3-kinase improves insulin signaling and ameliorates diabetes

Mauvais-Jarvis, F., Ueki, K., Fruman, D. A., Hirshman, M. F., Sakamoto, K., Goodyear, L. J., Iannacone, M., Accili, D., Cantley, L. C., & Kahn, C. R. (2002) · Journal of Clinical Investigation

Metabolism, Diabetes, and CancerPI3K/AKT/mTOR signaling in cancer

Cited by 207

TGF-β2 is an exercise-induced adipokine that regulates glucose and fatty acid metabolism

Takahashi, H., Alves, C. R. R., Stanford, K. I., Middelbeek, R. J. W., Nigro, P., Ryan, R. E., Xue, R., Sakaguchi, M., Lynes, M. D., So, K., et al. (2019) · Nature Metabolism

Adipokines, Inflammation, and Metabolic DiseasesAdipose Tissue and Metabolism

Cited by 204

Skeletal Muscle-Selective Knockout of LKB1 Increases Insulin Sensitivity, Improves Glucose Homeostasis, and Decreases TRB3

Koh, H.-J., Arnolds, D. E., Fujii, N., Tran, T. T., Rogers, M. J., Jessen, N., Li, Y., Liew, C. W., Ho, R. C., Hirshman, M. F., et al. (2006) · Molecular and Cellular Biology

Metabolism, Diabetes, and CancerAdipose Tissue and Metabolism

Cited by 202