Evidence for 5' AMP-activated protein kinase mediation of the effect of muscle contraction on glucose transport
Abstract
The intracellular signaling proteins that lead to exercise-stimulated glucose transport in skeletal muscle have not been identified, although it is clear that there are separate signaling mechanisms for exercise- and insulin-stimulated glucose transport. We have hypothesized that the 5'AMP-activated protein kinase (AMPK) functions as a signaling intermediary in exercise-stimulated glucose uptake. This hypothesis was based on recent studies showing the following: 1) muscle contraction increases AMPK activity and 2) perfusion of rat hindlimb skeletal muscles with 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR), a compound that results in increased AMPK activity, increased insulin-stimulated glucose uptake. In the current study, isolated rat epitrochlearis muscles were treated to contract in vitro (via electrical stimulation for 10 min) and/or incubated in the absence or presence of AICAR (2 mmol/l), insulin (1 micromol/l), or wortmannin (100 nmol/l). Both contraction and AICAR significantly increased AMPK activity, while the enzyme was not activated by insulin. AICAR, contraction, and insulin all increased 3-O-methylglucose (3MG) transport by threefold to fivefold above basal. The phosphatidylinositol 3-kinase (PI 3-kinase) inhibitor wortmannin completely blocked insulin-stimulated transport, but did not inhibit AICAR- or contraction-stimulated transport. The increase in glucose transport with the combination of maximal AICAR plus maximal insulin treatments was partially additive, suggesting that these stimuli increase glucose transport by different mechanisms. In contrast, there was no additive effect on glucose transport with the combination of AICAR plus contraction. These data suggest that AICAR and contraction stimulate glucose transport by a similar insulin-independent signaling mechanism and are consistent with the hypothesis that AMPK is involved in exercise-stimulated glucose uptake.
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AMPK is activated during exercise in both rodents and humans.
“Consistent with this, AMPK is activated during exercise in both rodents and humans [51-60], in an intensity-dependent manner [57,59-61].”
From AMPK and Exercise: Glucose Uptake and Insulin Sensitivity (2013) · cites this paper as [51]
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Park, C.-E., Kim, M., Lee, J. H., Min, B.-I., Bae, H., Choe, W., Kim, S. S., & Ha, J. (2007) · Experimental & Molecular Medicine · doi:10.1038/emm.2007.25 · Cited by 239 · see citing works
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Rabot, S., Membrez, M., Bruneau, A., Gérard, P., Harach, T., Moser, M., Raymond, F., Mansourian, R., & Chou, C. J. (2010) · The FASEB Journal · doi:10.1096/fj.10.164921 · Cited by 610 · see citing works
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Toyoda, T., Hayashi, T., Miyamoto, L., Yonemitsu, S., Nakano, M. H., Tanaka, S., Ebihara, K., Masuzaki, H., Hosoda, K., Inoue, G., et al. (2004) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00487.2003 · Cited by 137 · see citing works
Self-citationShih, C., Lin, C., Lin, W., & Wu, J. (2009) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2009.02.039 · Cited by 136 · see citing works
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Margaritelis, N. V., Paschalis, V., Theodorou, A. A., Kyparos, A., & Nikolaidis, M. G. (2020) · Redox Biology · doi:10.1016/j.redox.2020.101499 · Cited by 129 · see citing works
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- Authors
- Hayashi, T., Hirshman, M. F., Kurth, E. J., Winder, W. W., & Goodyear, L. J.
- Affiliations
- Brigham Young University (US)
- Brigham and Women's Hospital (US)
- Corresponding author
- Goodyear, L. J.
- Venue
- Diabetes
- Publisher
- American Diabetes Association
- Published
- 1998-08-01
- Volume
- 47
- Issue
- 8
- Pages
- 1369-1373
- ISSN
- 0012-1797 (ISSN-L)
- OpenAlex
- W2031532881
- Cited by
- 774
- References
- 0
- Citations by year
- 2026: 3 · 2025: 7 · 2024: 5 · 2023: 4 · 2022: 7 · 2021: 11 · 2020: 12 · 2019: 13 · 2018: 20 · 2017: 24 · 2016: 24 · 2015: 36 · 2014: 31 · 2013: 21 · 2012: 33
- FWCI
- 11.28
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Diabetes (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (AR-42238, R01AR041438, AR-41438)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
- Keywords
- AMPK, skeletal muscle glucose transport, muscle contraction, AICAR, insulin signaling, phosphatidylinositol 3-kinase, wortmannin, epitrochlearis muscle, 3-O-methylglucose transport
- MeSH terms
- Wortmannin, Aminoimidazole Carboxamide, Androstadienes, Animals, Biological Transport, Drug Synergism, Glucose, Hypoglycemic Agents, Insulin, Insulin Antagonists, Male, Multienzyme Complexes, Muscle Contraction, Protein Kinases, Ribonucleotides, Rats, Sprague-Dawley, Protein Serine-Threonine Kinases, Muscle, Skeletal, Rats, AMP-Activated Protein Kinases
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