Chang, Howard Y.

Single-cell multiomic analysis identifies regulatory programs in mixed-phenotype acute leukemia

Granja, J. M., Klemm, S., McGinnis, L. M., Kathiria, A. S., Mezger, A., Corces, M. R., Parks, B., Gars, E., Liedtke, M., Zheng, G. X. Y., et al. (2019) · Nature Biotechnology

Single-cell and spatial transcriptomicsGenomics and Chromatin Dynamics

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Enhancer connectome in primary human cells identifies target genes of disease-associated DNA elements

Mumbach, M. R., Satpathy, A. T., Boyle, E. A., Dai, C., Gowen, B. G., Cho, S. W., Nguyen, M. L., Rubin, A. J., Granja, J. M., Kazane, K. R., et al. (2017) · Nature Genetics

Genomics and Chromatin DynamicsGenetic Associations and Epidemiology

Cited by 490

Chromatin and gene-regulatory dynamics of the developing human cerebral cortex at single-cell resolution

Trevino, A. E., Müller, F., Andersen, J., Sundaram, L., Kathiria, A., Shcherbina, A., Farh, K., Chang, H. Y., Pașca, A. M., Kundaje, A., et al. (2021) · Cell

Single-cell and spatial transcriptomicsGenomics and Chromatin Dynamics

Cited by 478

Sensing Self and Foreign Circular RNAs by Intron Identity

Chen, Y. G., Kim, M. V., Chen, X., Batista, P. J., Aoyama, S., Wilusz, J. E., Iwasaki, A., & Chang, H. Y. (2017) · Molecular Cell

Circular RNAs in diseasesinterferon and immune responses

Cited by 475

Motif module map reveals enforcement of aging by continual NF-κB activity

Adler, A. S., Sinha, S., Kawahara, T. L. A., Zhang, J. Y., Segal, E., & Chang, H. Y. (2007) · Genes & Development

Genetics, Aging, and Longevity in Model OrganismsGenomics and Chromatin Dynamics

Cited by 466

Promoter of lncRNA Gene PVT1 Is a Tumor-Suppressor DNA Boundary Element

Cho, S. W., Xu, J., Sun, R., Mumbach, M. R., Carter, A. C., Chen, Y. G., Yost, K. E., Kim, J., He, J., Nevins, S. A., et al. (2018) · Cell

Cancer-related molecular mechanisms researchGenomics and Chromatin Dynamics

Cited by 459

The mammalian ribo-interactome reveals ribosome functional diversity and heterogeneity

Simsek, D., Tiu, G. C., Flynn, R. A., Byeon, G. W., Leppek, K., Xu, A. F., Chang, H. Y., & Barna, M. (2017) · Cell

RNA and protein synthesis mechanismsRNA modifications and cancer

Cited by 439

Single-cell epigenomic analyses implicate candidate causal variants at inherited risk loci for Alzheimer’s and Parkinson’s diseases

Corces, M. R., Shcherbina, A., Kundu, S., Gloudemans, M. J., Frésard, L., Granja, J. M., Louie, B. H., Eulalio, T., Shams, S., Bagdatli, S. T., et al. (2020) · Nature Genetics

Genetic Associations and EpidemiologyGenomics and Chromatin Dynamics

Cited by 358

Generation of pure GABAergic neurons by transcription factor programming

Yang, N., Chanda, S., Marro, S., Ng, Y.-H., Janas, J. A., Haag, D., Ang, C. E., Tang, Y., Flores, Q., Mall, M., et al. (2017) · Nature Methods

Pluripotent Stem Cells ResearchNeurogenesis and neuroplasticity mechanisms

Cited by 341

Coupled Single-Cell CRISPR Screening and Epigenomic Profiling Reveals Causal Gene Regulatory Networks

Rubin, A. J., Parker, K. R., Satpathy, A. T., Qi, Y., Wu, B., Ong, A. J., Mumbach, M. R., Ji, A. L., Kim, D. S., Cho, S. W., et al. (2019) · Cell

Genomics and Chromatin DynamicsCRISPR and Genetic Engineering

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Discovery of stimulation-responsive immune enhancers with CRISPR activation

Simeonov, D. R., Gowen, B. G., Boontanrart, M., Roth, T. L., Gagnon, J. D., Mumbach, M. R., Satpathy, A. T., Lee, Y., Bray, N. L., Chan, A. Y., et al. (2017) · Nature

Genomics and Chromatin DynamicsCRISPR and Genetic Engineering

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Lineage-specific dynamic and pre-established enhancer-promoter contacts cooperate in terminal differentiation

Rubin, A. J., Barajas, B. C., Furlan-Magaril, M., Lopez-Pajares, V., Mumbach, M. R., Howard, I., Kim, D. S., Boxer, L. D., Cairns, J., Spivakov, M., et al. (2017) · Nature Genetics

Genomics and Chromatin DynamicsChromatin Remodeling and Cancer

Cited by 293

Chromatin accessibility dynamics in a model of human forebrain development

Trevino, A. E., Sinnott-Armstrong, N., Andersen, J., Yoon, S.-J., Huber, N., Pritchard, J. K., Chang, H. Y., Greenleaf, W. J., & Pașca, S. P. (2020) · Science

Genomics and Chromatin DynamicsNeurogenesis and neuroplasticity mechanisms

Cited by 251

Xist ribonucleoproteins promote female sex-biased autoimmunity

Dou, D. R., Zhao, Y., Belk, J. A., Zhao, Y., Casey, K. M., Chen, D. C., Li, R., Yu, B., Srinivasan, S., Abe, B. T., et al. (2024) · Cell

Systemic Lupus Erythematosus ResearchGenetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities

Cited by 233

Age-Dependent Pancreatic Gene Regulation Reveals Mechanisms Governing Human β Cell Function

Arda, H. E., Li, L., Tsai, J., Torre, E. A., Rosli, Y., Peiris, H., Spitale, R. C., Dai, C., Gu, X., Qu, K., et al. (2016) · Cell Metabolism

Pancreatic function and diabetesDiabetes and associated disorders

Cited by 222

Activation of PDGF pathway links LMNA mutation to dilated cardiomyopathy

Lee, J., Termglinchan, V., Diecke, S., Itzhaki, I., Lam, C. K., Garg, P., Lau, E., Greenhaw, M., Seeger, T., Wu, H., et al. (2019) · Nature

Cardiomyopathy and Myosin StudiesCardiac electrophysiology and arrhythmias

Cited by 222

The road ahead in genetics and genomics

McGuire, A. L., Gabriel, S., Tishkoff, S. A., Wonkam, A., Chakravarti, A., Furlong, E. E. M., Treutlein, B., Meissner, A., Chang, H. Y., López-Bigas, N., et al. (2020) · Nature Reviews Genetics

Science, Research, and MedicineGenetic Associations and Epidemiology

Cited by 188

Genetic determinants of co-accessible chromatin regions in activated T cells across humans

Gate, R. E., Cheng, C. S., Aiden, A. P., Siba, A., Tabaka, M., Lituiev, D., Machol, I., Gordon, M. G., Subramaniam, M., Shamim, M., et al. (2018) · Nature Genetics

Genomics and Chromatin DynamicsGenetic Associations and Epidemiology

Cited by 181

Genome-Wide Analysis of KAP1 Binding Suggests Autoregulation of KRAB-ZNFs

O'Geen, H., Squazzo, S. L., Iyengar, S., Blahnik, K., Rinn, J. L., Chang, H. Y., Green, R., & Farnham, P. J. (2007) · PLoS Genetics

Genomics and Chromatin DynamicsEpigenetics and DNA Methylation

Cited by 178

A novel ATAC-seq approach reveals lineage-specific reinforcement of the open chromatin landscape via cooperation between BAF and p63

Bao, X., Rubin, A. J., Qu, K., Zhang, J., Giresi, P. G., Chang, H. Y., & Khavari, P. A. (2015) · Genome Biology

Genomics and Chromatin DynamicsChromatin Remodeling and Cancer

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Transcript-indexed ATAC-seq for precision immune profiling

Satpathy, A. T., Saligrama, N., Buenrostro, J. D., Wei, Y., Wu, B., Rubin, A. J., Granja, J. M., Lareau, C. A., Li, R., Qi, Y., et al. (2018) · Nature Medicine

Single-cell and spatial transcriptomicsGenomics and Chromatin Dynamics

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Single-cell epigenomic variability reveals functional cancer heterogeneity

Litzenburger, U. M., Buenrostro, J. D., Wu, B., Shen, Y., Sheffield, N. C., Kathiria, A., Greenleaf, W. J., & Chang, H. Y. (2017) · Genome Biology

Epigenetics and DNA MethylationGenomics and Chromatin Dynamics

Cited by 115

A Mutation in the Transcription Factor Foxp3 Drives T Helper 2 Effector Function in Regulatory T Cells

Van Gool, F., Nguyen, M. L. T., Mumbach, M. R., Satpathy, A. T., Rosenthal, W. L., Giacometti, S., Le, D. T., Liu, W., Brusko, T. M., Anderson, M. S., et al. (2019) · Immunity

T-cell and B-cell ImmunologyPsoriasis: Treatment and Pathogenesis

Cited by 102

Epigenomic priming of immune genes implicates oligodendroglia in multiple sclerosis susceptibility

Meijer, M., Agirre, E., Kabbe, M., van Tuijn, C. A., Heskol, A., Zheng, C., Mendanha Falcão, A., Bartosovic, M., Kirby, L., Calini, D., et al. (2022) · Neuron

Multiple Sclerosis Research StudiesGenomics and Chromatin Dynamics

Cited by 98