Cradick, Thomas J

DNA targeting specificity of RNA-guided Cas9 nucleases

Hsu, P. D., Scott, D. A., Weinstein, J. A., Ran, F. A., Konermann, S., Agarwala, V., Li, Y., Fine, E. J., Wu, X., Shalem, O., et al. (2013) · Nature Biotechnology

CRISPR and Genetic EngineeringRNA regulation and disease

Cited by 4,741

CRISPR/Cas9 systems have off-target activity with insertions or deletions between target DNA and guide RNA sequences

Lin, Y., Cradick, T. J., Brown, M. T., Deshmukh, H., Ranjan, P., Sarode, N., Wile, B. M., Vertino, P. M., Stewart, F. J., & Bao, G. (2014) · Nucleic Acids Research

CRISPR and Genetic EngineeringRNA regulation and disease

Cited by 634

CRISPR/Cas9 systems targeting β-globin and CCR5 genes have substantial off-target activity

Cradick, T. J., Fine, E. J., Antico, C. J., & Bao, G. (2013) · Nucleic Acids Research

CRISPR and Genetic EngineeringRNA regulation and disease

Cited by 590

COSMID: A Web-based Tool for Identifying and Validating CRISPR/Cas Off-target Sites

Cradick, T. J., Qiu, P., Lee, C. M., Fine, E. J., & Bao, G. (2014) · Molecular Therapy - Nucleic Acids

CRISPR and Genetic EngineeringRNA regulation and disease

Cited by 408

Seamless modification of wild-type induced pluripotent stem cells to the natural CCR5Δ32 mutation confers resistance to HIV infection

Ye, L., Wang, J., Beyer, A. I., Teque, F., Cradick, T. J., Qi, Z., Chang, J. C., Bao, G., Muench, M. O., Yu, J., et al. (2014) · Proceedings of the National Academy of Sciences

CRISPR and Genetic EngineeringHIV Research and Treatment

Cited by 320

Streptococcus thermophilus CRISPR-cas9 systems enable specific editing of the human genome

Müller, M., Lee, C. M., Gasiunas, G., Davis, T. H., Cradick, T. J., Siksnys, V., Bao, G., Cathomen, T., & Mussolino, C. (2016) · Molecular Therapy

CRISPR and Genetic EngineeringRNA regulation and disease

Cited by 254

Induction of fetal hemoglobin synthesis by CRISPR/Cas9-mediated editing of the human β-globin locus

Antoniani, C., Meneghini, V., Lattanzi, A., Felix, T., Romano, O., Magrin, E., Weber, L., Pavani, G., El Hoss, S., Kurita, R., et al. (2018) · Blood

Hemoglobinopathies and Related DisordersCRISPR and Genetic Engineering

Cited by 194

Zinc-finger nucleases as a novel therapeutic strategy for targeting hepatitis B virus DNAs

Cradick, T. J., Keck, K., Bradshaw, S., Jamieson, A. C., & McCaffrey, A. P. (2010) · Molecular Therapy

CRISPR and Genetic EngineeringHepatitis B Virus Studies

Cited by 184