Iredale, John P.

Resolving the fibrotic niche of human liver cirrhosis at single-cell level

Ramachandran, P., Dobie, R., Wilson-Kanamori, J. R., Dora, E. F., Henderson, B. E. P., Luu, N. T., Portman, J. R., Matchett, K. P., Brice, M., Marwick, J. A., et al. (2019) · Nature

Liver physiology and pathologyLiver Diseases and Immunity

Cited by 1,784

Selective depletion of macrophages reveals distinct, opposing roles during liver injury and repair

Duffield, J. S., Forbes, S. J., Constandinou, C. M., Clay, S., Partolina, M., Vuthoori, S., Wu, S., Lang, R., & Iredale, J. P. (2005) · Journal of Clinical Investigation

Liver physiology and pathologyWound Healing and Treatments

Cited by 1,649

Liver fibrosis and repair: Immune regulation of wound healing in a solid organ

Pellicoro, A., Ramachandran, P., Iredale, J. P., & Fallowfield, J. A. (2014) · Nature Reviews Immunology

Liver physiology and pathologyWound Healing and Treatments

Cited by 1,310

Mechanisms of spontaneous resolution of rat liver fibrosis. Hepatic stellate cell apoptosis and reduced hepatic expression of metalloproteinase inhibitors

Iredale, J. P., Benyon, R. C., Pickering, J., McCullen, M., Northrop, M., Pawley, S., Hovell, C., & Arthur, M. J. (1998) · Journal of Clinical Investigation

Liver physiology and pathologyLiver Disease Diagnosis and Treatment

Cited by 1,075

Differential Ly-6C expression identifies the recruited macrophage phenotype, which orchestrates the regression of murine liver fibrosis

Ramachandran, P., Pellicoro, A., Vernon, M. A., Boulter, L., Aucott, R. L., Ali, A., Hartland, S. N., Snowdon, V. K., Cappon, A., Gordon-Walker, T. T., et al. (2012) · Proceedings of the National Academy of Sciences

Liver physiology and pathologyCardiac Fibrosis and Remodeling

Cited by 1,001

Targeting of αv integrin identifies a core molecular pathway that regulates fibrosis in several organs

Henderson, N. C., Arnold, T. D., Katamura, Y., Giacomini, M. M., Rodriguez, J. D., McCarty, J. H., Pellicoro, A., Raschperger, E., Betsholtz, C., Ruminski, P. G., et al. (2013) · Nature Medicine

Liver physiology and pathologyCell Adhesion Molecules Research

Cited by 866

Models of liver fibrosis: exploring the dynamic nature of inflammation and repair in a solid organ

Iredale, J. P. (2007) · Journal of Clinical Investigation

Liver physiology and pathologyWound Healing and Treatments

Cited by 866

Macrophage-derived Wnt opposes Notch signaling to specify hepatic progenitor cell fate in chronic liver disease

Boulter, L., Govaere, O., Bird, T. G., Radulescu, S., Ramachandran, P., Pellicoro, A., Ridgway, R. A., Seo, S. S., Spee, B., Van Rooijen, N., et al. (2012) · Nature Medicine

Liver physiology and pathologyWnt/β-catenin signaling in development and cancer

Cited by 747

Matrix stiffness modulates proliferation, chemotherapeutic response, and dormancy in hepatocellular carcinoma cells

Schrader, J., Gordon-Walker, T. T., Aucott, R. L., van Deemter, M., Quaas, A., Walsh, S., Benten, D., Forbes, S. J., Wells, R. G., & Iredale, J. P. (2011) · Hepatology

Cellular Mechanics and InteractionsCancer Cells and Metastasis

Cited by 720

Galectin-3 Expression and Secretion Links Macrophages to the Promotion of Renal Fibrosis

Henderson, N. C., Mackinnon, A. C., Farnworth, S. L., Kipari, T., Haslett, C., Iredale, J. P., Liu, F.-T., Hughes, J., & Sethi, T. (2008) · The American Journal of Pathology

Galectins and Cancer BiologyChronic Kidney Disease and Diabetes

Cited by 562

Hepatic progenitor cells of biliary origin with liver repopulation capacity

Lu, W.-Y., Bird, T. G., Boulter, L., Tsuchiya, A., Cole, A. M., Hay, T., Guest, R. V., Wojtacha, D., Man, T. Y., Mackinnon, A., et al. (2015) · Nature Cell Biology

Liver physiology and pathologyMesenchymal stem cell research

Cited by 479

Scar-Associated Macrophages Are a Major Source of Hepatic Matrix Metalloproteinase-13 and Facilitate the Resolution of Murine Hepatic Fibrosis

Fallowfield, J. A., Mizuno, M., Kendall, T. J., Constandinou, C. M., Benyon, R. C., Duffield, J. S., & Iredale, J. P. (2007) · The Journal of Immunology

Liver physiology and pathologyCardiac Fibrosis and Remodeling

Cited by 479

Ly6Chi monocytes direct alternatively activated profibrotic macrophage regulation of lung fibrosis

Gibbons, M. A., MacKinnon, A. C., Ramachandran, P., Dhaliwal, K., Duffin, R., Phythian-Adams, A. T., van Rooijen, N., Haslett, C., Howie, S. E., Simpson, A. J., et al. (2011) · American Journal of Respiratory and Critical Care Medicine

Interstitial Lung Diseases and Idiopathic Pulmonary FibrosisTransplantation: Methods and Outcomes

Cited by 466

Generation of Functional Human Hepatic Endoderm From Human Induced Pluripotent Stem Cells

Sullivan, G. J., Hay, D. C., Park, I.-H., Fletcher, J., Hannoun, Z., Payne, C. M., Dalgetty, D., Black, J. R., Ross, J. A., Samuel, K., et al. (2010) · Hepatology

Pluripotent Stem Cells ResearchDrug-Induced Hepatotoxicity and Protection

Cited by 445

Inhibition of Apoptosis of Activated Hepatic Stellate Cells by Tissue Inhibitor of Metalloproteinase-1 Is Mediated via Effects on Matrix Metalloproteinase Inhibition

Murphy, F. R., Issa, R., Zhou, X., Ratnarajah, S., Arthur, M. J. P., Benyon, C., Iredale, J. P., & Nagase, H. (2002) · Journal of Biological Chemistry

Liver physiology and pathologyProtease and Inhibitor Mechanisms

Cited by 432

Macrophage therapy for murine liver fibrosis recruits host effector cells improving fibrosis, regeneration, and function

Thomas, J. A., Pope, C., Wojtacha, D., Robson, A. J., Gordon-Walker, T. T., Hartland, S., Ramachandran, P., Van Deemter, M., Hume, D. A., Iredale, J. P., et al. (2011) · Hepatology

Liver physiology and pathologyMesenchymal stem cell research

Cited by 346

Tissue Inhibitor of Metalloproteinase–1 Messenger Rna Expression Is Enhanced Relative to Interstitial Collagenase Messenger Rna in Experimental Liver Injury and Fibrosis

Iredale, J. P., Benyon, R. C., Arthur, M. J., Ferris, W. F., Alcolado, R., Winwood, P. J., Clark, N., & Murphy, G. (1996) · Hepatology

Liver physiology and pathologyProtease and Inhibitor Mechanisms

Cited by 324

Liver fibrosis: cellular mechanisms of progression and resolution

Henderson, N. C., & Iredale, J. P. (2007) · Clinical Science

Liver physiology and pathologyLiver Disease Diagnosis and Treatment

Cited by 270

TGFβ inhibition restores a regenerative response in acute liver injury by suppressing paracrine senescence

Bird, T. G., Müller, M., Boulter, L., Vincent, D. F., Ridgway, R. A., Lopez-Guadamillas, E., Lu, W.-Y., Jamieson, T., Govaere, O., Campbell, A. D., et al. (2018) · Science Translational Medicine

Liver physiology and pathologyDrug-Induced Hepatotoxicity and Protection

Cited by 261

Human hepatic lipocytes synthesize tissue inhibitor of metalloproteinases-1. Implications for regulation of matrix degradation in liver.

Iredale, J. P., Murphy, G., Hembry, R. M., Friedman, S. L., & Arthur, M. J. (1992) · Journal of Clinical Investigation

Liver physiology and pathologyProtease and Inhibitor Mechanisms

Cited by 202

Characterisation of a stereotypical cellular and extracellular adult liver progenitor cell niche in rodents and diseased human liver

Lorenzini, S., Bird, T. G., Boulter, L., Bellamy, C., Samuel, K., Aucott, R., Clayton, E., Andreone, P., Bernardi, M., Golding, M., et al. (2010) · Gut

Liver physiology and pathologyMesenchymal stem cell research

Cited by 190

Bone marrow injection stimulates hepatic ductular reactions in the absence of injury via macrophage-mediated TWEAK signaling

Bird, T. G., Lu, W.-Y., Boulter, L., Gordon-Keylock, S., Ridgway, R. A., Williams, M. J., Taube, J., Thomas, J. A., Wojtacha, D., Gambardella, A., et al. (2013) · Proceedings of the National Academy of Sciences

Liver physiology and pathologyMesenchymal stem cell research

Cited by 166

Tissue inhibitors of metalloproteinases in liver fibrosis

Iredale, J. P. (1997) · The International Journal of Biochemistry & Cell Biology

Liver physiology and pathologyProtease and Inhibitor Mechanisms

Cited by 165

Reversibility of liver fibrosis

Pellicoro, A., Ramachandran, P., & Iredale, J. P. (2012) · Fibrogenesis & Tissue Repair

Liver physiology and pathologyLiver Disease Diagnosis and Treatment

Cited by 135