Cited by 866Liver physiology and pathologyWound Healing and TreatmentsLiver Disease Diagnosis and Treatment

Models of liver fibrosis: exploring the dynamic nature of inflammation and repair in a solid organ

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Iredale, John P.·2007·Journal of Clinical Investigation

Abstract

Models of liver fibrosis, which include cell culture models, explanted and biopsied human material, and experimental animal models, have demonstrated that liver fibrosis is a highly dynamic example of solid organ wound healing. Recent work in human and animal models has shown that liver fibrosis is potentially reversible and, in specific circumstances, demonstrates resolution with a restoration of near normal architecture. This Review highlights the manner in which studies of models of liver fibrosis have contributed to the paradigm of dynamic wound healing in this solid organ.

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Authors
Iredale, J. P.
Affiliations
Centre for Inflammation Research (GB)
Corresponding author
Iredale, John P.
Venue
Journal of Clinical Investigation
Published
2007-03-01
Volume
117
Issue
3
Pages
539-548
ISSN
0021-9738 (ISSN-L)
OpenAlex
W2120335459
Cited by
866
References
128
Citations by year
2026: 19 · 2025: 40 · 2024: 45 · 2023: 39 · 2022: 32 · 2021: 39 · 2020: 34 · 2019: 36 · 2018: 39 · 2017: 36 · 2016: 51 · 2015: 63 · 2014: 61 · 2013: 57 · 2012: 55
FWCI
7.58
Type
journal article
Language
en
Open access
Locations
  • Journal of Clinical Investigation (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • Edinburgh Research Explorer (University of Edinburgh) (submittedVersion, other-oa)
Funders
  • Wellcome Trust
  • Children's Liver Disease Foundation
  • Medical Research Council
Topics
  • Health Sciences › Medicine › Hepatology › Liver physiology and pathology
  • Health Sciences › Medicine › Rehabilitation › Wound Healing and Treatments
  • Health Sciences › Medicine › Epidemiology › Liver Disease Diagnosis and Treatment
Keywords
liver fibrosis, wound healing, inflammation, tissue repair, animal models, cell culture model, liver regeneration
MeSH terms
Animals, Disease Models, Animal, Extracellular Matrix, Fibroblasts, Humans, Inflammation, Liver Cirrhosis, Liver Cirrhosis, Experimental, Liver Regeneration, Models, Biological, Wound Healing

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