Hafen, Ernst

Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex

Brugarolas, J., Lei, K., Hurley, R. L., Manning, B. D., Reiling, J. H., Hafen, E., Witters, L. A., Ellisen, L. W., & Kaelin, W. G. (2004) · Genes & Development

PI3K/AKT/mTOR signaling in cancerCancer, Hypoxia, and Metabolism

Cited by 1,384

An evolutionarily conserved function of the Drosophila insulin receptor and insulin-like peptides in growth control

Brogiolo, W., Stocker, H., Ikeya, T., Rintelen, F., Fernandez, R., & Hafen, E. (2001) · Current Biology

PI3K/AKT/mTOR signaling in cancerMetabolism, Diabetes, and Cancer

Cited by 1,255

Insulin Activation of Rheb, a Mediator of mTOR/S6K/4E-BP Signaling, Is Inhibited by TSC1 and 2

Garami, A., Zwartkruis, F. J. T., Nobukuni, T., Joaquin, M., Roccio, M., Stocker, H., Kozma, S. C., Hafen, E., Bos, J. L., & Thomas, G. (2003) · Molecular Cell

PI3K/AKT/mTOR signaling in cancerTuberous Sclerosis Complex Research

Cited by 1,043

Longer lifespan, altered metabolism, and stress resistance in Drosophila from ablation of cells making insulin-like ligands

Broughton, S. J., Piper, M. D. W., Ikeya, T., Bass, T. M., Jacobson, J., Driege, Y., Martinez, P., Hafen, E., Withers, D. J., Leevers, S. J., et al. (2005) · Proceedings of the National Academy of Sciences

Genetics, Aging, and Longevity in Model OrganismsNeurobiology and Insect Physiology Research

Cited by 822

The ETS domain protein Pointed-P2 is a target of MAP kinase in the Sevenless signal transduction pathway

Brunner, D., Dücker, K., Oellers, N., Hafen, E., Scholzi, H., & Klambt, C. (1994) · Nature

Protein Kinase Regulation and GTPase SignalingDevelopmental Biology and Gene Regulation

Cited by 366

Will Democracy Survive Big Data and Artificial Intelligence?

Helbing, D., Frey, B. S., Gigerenzer, G., Hafen, E., Hagner, M., Hofstetter, Y., van den Hoven, J., Zicari, R. V., & Zwitter, A. (2019) · Towards Digital Enlightenment

Ethics and Social Impacts of AIPolitical Theory and Democracy

Cited by 355

Autophagy in Drosophila ovaries is induced by starvation and is required for oogenesis

Barth, J. M. I., Szabad, J., Hafen, E., & Köhler, K. (2011) · Cell Death & Differentiation

Autophagy in Disease and TherapyGenetics, Aging, and Longevity in Model Organisms

Cited by 165

Substrate-dependent control of MAPK phosphorylation in vivo

Kim, Y., Paroush, Z., Nairz, K., Hafen, E., Jiménez, G., & Shvartsman, S. Y. (2011) · Molecular Systems Biology

Protein Kinase Regulation and GTPase SignalingProtein Tyrosine Phosphatases

Cited by 80