Longer lifespan, altered metabolism, and stress resistance in Drosophila from ablation of cells making insulin-like ligands
Open accessAbstract
The insulin/insulin-like growth factor-like signaling pathway, present in all multicellular organisms, regulates diverse functions including growth, development, fecundity, metabolic homeostasis, and lifespan. In flies, ligands of the insulin/insulin-like growth factor-like signaling pathway, the Drosophila insulin-like peptides, regulate growth and hemolymph carbohydrate homeostasis during development and are expressed in a stage- and tissue-specific manner. Here, we show that ablation of Drosophila insulin-like peptide-producing median neurosecretory cells in the brain leads to increased fasting glucose levels in the hemolymph of adults similar to that found in diabetic mammals. They also exhibit increased storage of lipid and carbohydrate, reduced fecundity, and reduced tolerance of heat and cold. However, the ablated flies show an extension of median and maximal lifespan and increased resistance to oxidative stress and starvation.
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Reduced IIS specifically in the nervous system is sufficient to extend lifespan in several model systems.
“Importantly, reduced IIS specifically in the nervous system is sufficient to extend lifespan in several model systems.”
From Neural mechanisms of ageing and cognitive decline (2010) · cites this paper as [67]
Ablating specific neurons can increase lifespan in worms and flies.
“Furthermore, ablation of specific neurons can increase lifespan in worms (91) and flies (67).”
From Neural mechanisms of ageing and cognitive decline (2010) · cites this paper as [67]
Dietary sugars, proteins and lipids induce insulin release into circulation by directly or indirectly affecting insulin-producing cells.
“Dietary sugars, proteins and lipids induce insulin release into the circulation by directly or indirectly affecting insulin-producing cells [65,66].”
From An option space for early neural evolution (2015) · cites this paper as [65]
Insulin-related peptides produced by neurosecretory cells in flies and other metazoans regulate glucose levels in haemolymph and lipid and carbohydrate storage.
“Insulin-related peptides, produced by neurosecretory cells in flies and other metazoans, regulate glucose levels in the haemolymph, and lipid and carbohydrate storage.”
From An option space for early neural evolution (2015) · cites this paper as [65]
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- Authors
- Broughton, S. J., Piper, M. D. W., Ikeya, T., Bass, T. M., Jacobson, J., Driege, Y., Martinez, P., Hafen, E., Withers, D. J., Leevers, S. J., & Partridge, L.
- Affiliations
- University of Zurich (CH)
- ORCID
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2005-02-11
- Volume
- 102
- Issue
- 8
- Pages
- 3105-3110
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC549445
- OpenAlex
- W2107900138
- Cited by
- 822
- References
- 65
- Citations by year
- 2026: 17 · 2025: 35 · 2024: 30 · 2023: 32 · 2022: 48 · 2021: 50 · 2020: 55 · 2019: 32 · 2018: 52 · 2017: 29 · 2016: 48 · 2015: 51 · 2014: 42 · 2013: 50 · 2012: 42
- FWCI
- 8.95
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Zurich Open Repository and Archive (University of Zurich) (acceptedVersion, other-oa)
- Lancaster EPrints (Lancaster University) (submittedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Zurich Open Repository and Archive (University of Zurich) (submittedVersion, other-oa)
- Zurich Open Repository and Archive (University of Zurich)
- Funders
- Wellcome Trust
- Biotechnology and Biological Sciences Research Council (SF19106)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurobiology and Insect Physiology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Keywords
- insulin-like peptides, median neurosecretory cells, cell ablation, lifespan extension, fasting blood glucose, fecundity, heat tolerance, oxidative stress resistance, starvation resistance, Drosophila
- MeSH terms
- Animals, Drosophila, Fertility, Insulin, Longevity, Somatomedins, Starvation, Signal Transduction, Oxidative Stress, Drosophila Proteins, Carbohydrate Metabolism, Lipid Metabolism
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