Robson, Simon C.

Negative feedback control of neuronal activity by microglia

Badimon, A., Strasburger, H. J., Ayata, P., Chen, X., Nair, A., Ikegami, A., Hwang, P., Chan, A. T., Graves, S. M., Uweru, J. O., et al. (2020) · Nature

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The ectonucleotidases CD 39 and CD 73: Novel checkpoint inhibitor targets

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Control of tumor-associated macrophages and T cells in glioblastoma via AHR and CD39

Takenaka, M. C., Gabriely, G., Rothhammer, V., Mascanfroni, I. D., Wheeler, M. A., Chao, C.-C., Gutiérrez-Vázquez, C., Kenison, J., Tjon, E. C., Barroso, A., et al. (2019) · Nature Neuroscience

Immune cells in cancerGlioma Diagnosis and Treatment

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Coordinated Adenine Nucleotide Phosphohydrolysis and Nucleoside Signaling in Posthypoxic Endothelium

Eltzschig, H. K., Ibla, J. C., Furuta, G. T., Leonard, M. O., Jacobson, K. A., Enjyoji, K., Robson, S. C., & Colgan, S. P. (2003) · The Journal of Experimental Medicine

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Stat3 and Gfi-1 transcription factors control Th17 cell immunosuppressive activity via the regulation of ectonucleotidase expression

Chalmin, F., Mignot, G., Bruchard, M., Chevriaux, A., Végran, F., Hichami, A., Ladoire, S., Derangère, V., Vincent, J., Masson, D., et al. (2012) · Immunity

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CD39 is the dominant Langerhans cell–associated ecto-NTPDase: Modulatory roles in inflammation and immune responsiveness

Mizumoto, N., Kumamoto, T., Robson, S. C., Sévigny, J., Matsue, H., Enjyoji, K., & Takashima, A. (2002) · Nature Medicine

Adenosine and Purinergic SignalingBiochemical and Molecular Research

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The metabolite BH4 controls T cell proliferation in autoimmunity and cancer

Cronin, S. J. F., Seehus, C., Weidinger, A., Talbot, S., Reissig, S., Seifert, M., Pierson, Y., McNeill, E., Longhi, M. S., Turnes, B. L., et al. (2018) · Nature

T-cell and B-cell ImmunologyBiochemical and Molecular Research

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CD39 deletion exacerbates experimental murine colitis and human polymorphisms increase susceptibility to inflammatory bowel disease

Friedman, D. J., Künzli, B. M., A-Rahim, Y. I., Sevigny, J., Berberat, P. O., Enjyoji, K., Csizmadia, E., Friess, H., & Robson, S. C. (2009) · Proceedings of the National Academy of Sciences

Inflammatory Bowel DiseaseAdenosine and Purinergic Signaling

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Hypoxia drives CD39-dependent suppressor function in exhausted T cells to limit antitumor immunity

Vignali, P. D. A., DePeaux, K., Watson, M. J., Ye, C., Ford, B. R., Lontos, K., McGaa, N. K., Scharping, N. E., Menk, A. V., Robson, S. C., et al. (2023) · Nature Immunology

Cancer Immunotherapy and BiomarkersT-cell and B-cell Immunology

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The mitochondrial uncoupling protein-2 promotes chemoresistance in cancer cells

Derdak, Z., Mark, N. M., Beldi, G., Robson, S. C., Wands, J. R., & Baffy, G. (2008) · Cancer Research

Mitochondrial Function and PathologyCell death mechanisms and regulation

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Multiomics of Tissue Extracellular Vesicles Identifies Unique Modulators of Atherosclerosis and Calcific Aortic Valve Stenosis

Blaser, M. C., Buffolo, F., Halu, A., Turner, M. E., Schlotter, F., Higashi, H., Pantano, L., Clift, C. L., Saddic, L. A., Atkins, S. K., et al. (2023) · Circulation

Extracellular vesicles in diseaseAtherosclerosis and Cardiovascular Diseases

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Mitochondrial recoupling: a novel therapeutic strategy for cancer

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Mitochondrial Function and PathologyCancer, Hypoxia, and Metabolism

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P2X7 Receptor Signaling Contributes to Sepsis-Associated Brain Dysfunction

Savio, L. E. B., Andrade, M. G. J., de Andrade Mello, P., Santana, P. T., Moreira-Souza, A. C. A., Kolling, J., Longoni, A., Feldbrügge, L., Wu, Y., Wyse, A. T. S., et al. (2017) · Molecular Neurobiology

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Heightened expression of CD39 by regulatory T lymphocytes is associated with therapeutic remission in inflammatory bowel disease

Gibson, D. J., Elliott, L., McDermott, E., Tosetto, M., Keegan, D., Byrne, K., Martin, S. T., Rispens, T., Cullen, G., Mulcahy, H. E., et al. (2015) · Inflammatory Bowel Diseases

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Mo1228 Fecal Microbiota Transplantation Induces Early Improvement in Symptoms in Patients With Active Crohn's Disease

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Heme oxygenase-1 mitigates liver injury and fibrosis via modulation of LNX1/Notch1 pathway in myeloid cells

Canesin, G., Feldbrügge, L., Wei, G., Janovicova, L., Janikova, M., Csizmadia, E., Ariffin, J., Hedblom, A., Herbert, Z. T., Robson, S. C., et al. (2022) · iScience

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