Prchal, Josef T.

Genetic Evidence for High-Altitude Adaptation in Tibet

Simonson, T. S., Yang, Y., Huff, C. D., Yun, H., Qin, G., Witherspoon, D. J., Bai, Z., Lorenzo, F. R., Xing, J., Jorde, L. B., et al. (2010) · Science

High Altitude and HypoxiaForensic and Genetic Research

Cited by 1,227

Essential role for Nix in autophagic maturation of erythroid cells

Sandoval, H., Thiagarajan, P., Dasgupta, S. K., Schumacher, A., Prchal, J. T., Chen, M., & Wang, J. (2008) · Nature

Autophagy in Disease and TherapyCell death mechanisms and regulation

Cited by 1,185

Disruption of oxygen homeostasis underlies congenital Chuvash polycythemia

Ang, S. O., Chen, H., Hirota, K., Gordeuk, V. R., Jelinek, J., Guan, Y., Liu, E., Sergueeva, A. I., Miasnikova, G. Y., Mole, D., et al. (2002) · Nature Genetics

Erythropoietin and Anemia TreatmentCancer, Hypoxia, and Metabolism

Cited by 510

Somatic HIF2A Gain-of-Function Mutations in Paraganglioma with Polycythemia

Zhuang, Z., Yang, C., Lorenzo, F., Merino, M., Fojo, T., Kebebew, E., Popovic, V., Stratakis, C. A., Prchal, J. T., & Pacak, K. (2012) · New England Journal of Medicine

Adrenal and Paraganglionic TumorsCancer, Hypoxia, and Metabolism

Cited by 397

Congenital disorder of oxygen sensing: association of the homozygous Chuvash polycythemia VHL mutation with thrombosis and vascular abnormalities but not tumors

Gordeuk, V. R., Sergueeva, A. I., Miasnikova, G. Y., Okhotin, D., Voloshin, Y., Choyke, P. L., Butman, J. A., Jedlickova, K., Prchal, J. T., & Polyakova, L. A. (2004) · Blood

Erythropoietin and Anemia TreatmentCancer, Hypoxia, and Metabolism

Cited by 273

Regulated expression of microRNAs in normal and polycythemia vera erythropoiesis

Bruchova, H., Yoon, D., Agarwal, A. M., Mendell, J., & Prchal, J. T. (2007) · Experimental Hematology

Myeloproliferative Neoplasms: Diagnosis and TreatmentMicroRNA in disease regulation

Cited by 214

A novel EPAS1/HIF2A germline mutation in a congenital polycythemia with paraganglioma

Lorenzo, F. R., Yang, C., Ng Tang Fui, M., Vankayalapati, H., Zhuang, Z., Huynh, T., Grossmann, M., Pacak, K., & Prchal, J. T. (2013) · Journal of Molecular Medicine

Adrenal and Paraganglionic TumorsEar and Head Tumors

Cited by 171

Development of a Novel Trans-Lentiviral Vector That Affords Predictable Safety

Wu, X., Wakefield, J. K., Liu, H., Xiao, H., Kralovics, R., Prchal, J. T., & Kappes, J. C. (2000) · Molecular Therapy

Virus-based gene therapy researchRNA Interference and Gene Delivery

Cited by 137

Mutations in the VHL gene in sporadic apparently congenital polycythemia

Pastore, Y. D., Jelinek, J., Ang, S., Guan, Y., Liu, E., Jedlickova, K., Krishnamurti, L., & Prchal, J. T. (2003) · Blood

Erythropoietin and Anemia TreatmentCancer, Hypoxia, and Metabolism

Cited by 136

Endemic Polycythemia in Russia: Mutation in the VHL Gene

Ang, S. O., Chen, H., Gordeuk, V. R., Sergueeva, A. I., Polyakova, L. A., Miasnikova, G. Y., Kralovics, R., Stockton, D. W., & Prchal, J. T. (2002) · Blood Cells, Molecules, and Diseases

Erythropoietin and Anemia TreatmentHemoglobinopathies and Related Disorders

Cited by 135

Mutations of von Hippel-Lindau tumor-suppressor gene and congenital polycythemia

Pastore, Y., Jedlickova, K., Guan, Y., Liu, E., Fahner, J., Hasle, H., Prchal, J. F., & Prchal, J. T. (2003) · The American Journal of Human Genetics

Erythropoietin and Anemia TreatmentCancer, Hypoxia, and Metabolism

Cited by 106

Disruption of ferroportin 1 regulation causes dynamic alterations in iron homeostasis and erythropoiesis in polycythaemia mice

Mok, H., Jelinek, J., Pai, S., Cattanach, B. M., Prchal, J. T., Youssoufian, H., & Schumacher, A. (2004) · Development

Iron Metabolism and DisordersNeurological diseases and metabolism

Cited by 73

The worldwide distribution of the VHL 598C>T mutation indicates a single founding event

Liu, E., Percy, M. J., Amos, C. I., Guan, Y., Shete, S., Stockton, D. W., McMullin, M. F., Polyakova, L. A., Ang, S. O., Pastore, Y. D., et al. (2004) · Blood

Genetic Associations and EpidemiologyForensic and Genetic Research

Cited by 66

Regulation of ferrochelatase gene expression by hypoxia

Liu, Y. L., Ang, S. O., Weigent, D. A., Prchal, J. T., & Bloomer, J. R. (2004) · Life Sciences

Heme Oxygenase-1 and Carbon MonoxideCancer, Hypoxia, and Metabolism

Cited by 60

Chuvash polycythemia VHLR200W mutation is associated with down-regulation of hepcidin expression

Gordeuk, V. R., Miasnikova, G. Y., Sergueeva, A. I., Niu, X., Nouraie, M., Okhotin, D. J., Polyakova, L. A., Ammosova, T., Nekhai, S., Ganz, T., et al. (2011) · Blood

Iron Metabolism and DisordersErythropoietin and Anemia Treatment

Cited by 51