Dube, Umber

An atlas of cortical circular RNA expression in Alzheimer disease brains demonstrates clinical and pathological associations

Dube, U., Del-Aguila, J. L., Li, Z., Budde, J. P., Jiang, S., Hsu, S., Ibanez, L., Fernandez, M. V., Farias, F., Norton, J., et al. (2019) · Nature Neuroscience

Circular RNAs in diseasesAlzheimer's disease research and treatments

Cited by 345

Genomic atlas of the proteome from brain, CSF and plasma prioritizes proteins implicated in neurological disorders

Yang, C., Farias, F. H. G., Ibanez, L., Suhy, A., Sadler, B., Fernandez, M. V., Wang, F., Bradley, J. L., Eiffert, B., Bahena, J. A., et al. (2021) · Nature Neuroscience

Genetic Associations and EpidemiologyGenetic Mapping and Diversity in Plants and Animals

Cited by 290

The MS4A gene cluster is a key modulator of soluble TREM2 and Alzheimer’s disease risk

Deming, Y., Filipello, F., Cignarella, F., Cantoni, C., Hsu, S., Mikesell, R., Li, Z., Del-Aguila, J. L., Dube, U., Farias, F. G., et al. (2019) · Science Translational Medicine

Neuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatments

Cited by 271

A single-nuclei RNA sequencing study of Mendelian and sporadic AD in the human brain

Del-Aguila, J. L., Li, Z., Dube, U., Mihindukulasuriya, K. A., Budde, J. P., Fernandez, M. V., Ibanez, L., Bradley, J., Wang, F., Bergmann, K., et al. (2019) · Alzheimer's Research & Therapy

Single-cell and spatial transcriptomicsAlzheimer's disease research and treatments

Cited by 183

APOE genotype regulates pathology and disease progression in synucleinopathy

Davis, A. A., Inman, C. E., Wargel, Z. M., Dube, U., Freeberg, B. M., Galluppi, A., Haines, J. N., Dhavale, D. D., Miller, R., Choudhury, F. A., et al. (2020) · Science Translational Medicine

Parkinson's Disease Mechanisms and TreatmentsAlzheimer's disease research and treatments

Cited by 177

Species-dependent posttranscriptional regulation of NOS1 by FMRP in the developing cerebral cortex

Kwan, K. Y., Lam, M. M. S., Johnson, M. B., Dube, U., Shim, S., Rašin, M.-R., Sousa, A. M. M., Fertuzinhos, S., Chen, J.-G., Arellano, J. I., et al. (2012) · Cell

Genetics and Neurodevelopmental DisordersRNA Research and Splicing

Cited by 137

The TMEM106B FTLD-protective variant, rs1990621, is also associated with increased neuronal proportion

Li, Z., Farias, F. H. G., Dube, U., Del-Aguila, J. L., Mihindukulasuriya, K. A., Fernandez, M. V., Ibanez, L., Budde, J. P., Wang, F., Lake, A. M., et al. (2020) · Acta Neuropathologica

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 85

Integrative system biology analyses of CRISPR-edited iPSC-derived neurons and human brains reveal deficiencies of presynaptic signaling in FTLD and PSP

Jiang, S., Wen, N., Li, Z., Dube, U., Del Aguila, J., Budde, J., Martinez, R., Hsu, S., Fernandez, M. V., Cairns, N. J., et al. (2018) · Translational Psychiatry

Alzheimer's disease research and treatmentsAmyotrophic Lateral Sclerosis Research

Cited by 73

Genetic variants associated with Alzheimer’s disease confer different cerebral cortex cell-type population structure

The Dominantly Inherited Alzheimer Network (DIAN), Li, Z., Del-Aguila, J. L., Dube, U., Budde, J., Martinez, R., Black, K., Xiao, Q., Cairns, N. J., Dougherty, J. D., et al. (2018) · Genome Medicine

Alzheimer's disease research and treatmentsSingle-cell and spatial transcriptomics

Cited by 56

Examination of the Effect of Rare Variants in TREM2 , ABI3 , and PLCG2 in LOAD Through Multiple Phenotypes

Olive, C., Ibanez, L., Farias, F. H. G., Wang, F., Budde, J. P., Norton, J. B., Gentsch, J., Morris, J. C., Li, Z., Dube, U., et al. (2020) · Journal of Alzheimer’s Disease

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 32

Overlap in the Genetic Architecture of Stroke Risk, Early Neurological Changes, and Cardiovascular Risk Factors

Ibanez, L., Heitsch, L., Dube, U., Farias, F. H. G., Budde, J., Bergmann, K., Davenport, R., Bradley, J., Carrera, C., Kinnunen, J., et al. (2019) · Stroke

Genetic Associations and EpidemiologyAcute Ischemic Stroke Management

Cited by 23

A single-nuclei RNA sequencing study of Mendelian and sporadic AD in the human brain

Del-Aguila, J. L., Li, Z., Dube, U., Mihindukulasuriya, K. A., Budde, J. P., Fernandez, M. V., Ibanez, L., Bradley, J., Wang, F., Bergmann, K., et al. (2019) · bioRxiv (Cold Spring Harbor Laboratory)

Single-cell and spatial transcriptomicsAlzheimer's disease research and treatments

Cited by 12