Powers, Alvin C.

Assessment of Human Pancreatic Islet Architecture and Composition by Laser Scanning Confocal Microscopy

Brissova, M., Fowler, M. J., Nicholson, W. E., Chu, A., Hirshberg, B., Harlan, D. M., & Powers, A. C. (2005) · Journal of Histochemistry & Cytochemistry

Pancreatic function and diabetesDiabetes and associated disorders

Cited by 797

Inactivation of specific β cell transcription factors in type 2 diabetes

Guo, S., Dai, C., Guo, M., Taylor, B., Harmon, J. S., Sander, M., Robertson, R. P., Powers, A. C., & Stein, R. (2013) · Journal of Clinical Investigation

Pancreatic function and diabetesDiabetes and associated disorders

Cited by 520

β-Cell Failure in Type 2 Diabetes: Postulated Mechanisms and Prospects for Prevention and Treatment

Halban, P. A., Polonsky, K. S., Bowden, D. W., Hawkins, M. A., Ling, C., Mather, K. J., Powers, A. C., Rhodes, C. J., Sussel, L., & Weir, G. C. (2014) · Diabetes Care

Pancreatic function and diabetesDiabetes Treatment and Management

Cited by 460

Endocrine toxicities of immune checkpoint inhibitors

Wright, J. J., Powers, A. C., & Johnson, D. B. (2021) · Nature Reviews Endocrinology

Cancer Immunotherapy and BiomarkersAdrenal Hormones and Disorders

Cited by 441

p16Ink4a-induced senescence of pancreatic beta cells enhances insulin secretion

Helman, A., Klochendler, A., Azazmeh, N., Gabai, Y., Horwitz, E., Anzi, S., Swisa, A., Condiotti, R., Granit, R. Z., Nevo, Y., et al. (2016) · Nature Medicine

Pancreatic function and diabetesTelomeres, Telomerase, and Senescence

Cited by 351

Insulin Access and Affordability Working Group: Conclusions and Recommendations

Cefalu, W. T., Dawes, D. E., Gavlak, G., Goldman, D., Herman, W. H., Van Nuys, K., Powers, A. C., Taylor, S. I., Yatvin, A. L., & on behalf of the Insulin Access and Affordability Working Group (2018) · Diabetes Care

Pharmaceutical Economics and PolicyDiabetes Management and Research

Cited by 256

Multiplexed In Situ Imaging Mass Cytometry Analysis of the Human Endocrine Pancreas and Immune System in Type 1 Diabetes

Wang, Y. J., Traum, D., Schug, J., Gao, L., Liu, C., Atkinson, M. A., Powers, A. C., Feldman, M. D., Naji, A., Chang, K.-M., et al. (2019) · Cell Metabolism

Diabetes and associated disordersPancreatic function and diabetes

Cited by 228

Age-Dependent Pancreatic Gene Regulation Reveals Mechanisms Governing Human β Cell Function

Arda, H. E., Li, L., Tsai, J., Torre, E. A., Rosli, Y., Peiris, H., Spitale, R. C., Dai, C., Gu, X., Qu, K., et al. (2016) · Cell Metabolism

Pancreatic function and diabetesDiabetes and associated disorders

Cited by 222

Suppression of Insulin Production and Secretion by a Decretin Hormone

Alfa, R. W., Park, S., Skelly, K.-R., Poffenberger, G., Jain, N., Gu, X., Kockel, L., Wang, J., Liu, Y., Powers, A. C., et al. (2015) · Cell Metabolism

Pancreatic function and diabetesNeuropeptides and Animal Physiology

Cited by 150

Gut-Proglucagon-Derived Peptides Are Essential for Regulating Glucose Homeostasis in Mice

Song, Y., Koehler, J. A., Baggio, L. L., Powers, A. C., Sandoval, D. A., & Drucker, D. J. (2019) · Cell Metabolism

Diabetes Treatment and ManagementPancreatic function and diabetes

Cited by 140

PDX1 deficiency causes mitochondrial dysfunction and defective insulin secretion through TFAM suppression

Gauthier, B. R., Wiederkehr, A., Baquié, M., Dai, C., Powers, A. C., Kerr-Conte, J., Pattou, F., MacDonald, R. J., Ferrer, J., & Wollheim, C. B. (2009) · Cell Metabolism

Pancreatic function and diabetesMitochondrial Function and Pathology

Cited by 115

Aldosterone decreases glucose-stimulated insulin secretion in vivo in mice and in murine islets

Luther, J. M., Luo, P., Kreger, M. T., Brissova, M., Dai, C., Whitfield, T. T., Kim, H. S., Wasserman, D. H., Powers, A. C., & Brown, N. J. (2011) · Diabetologia

Pancreatic function and diabetesHormonal Regulation and Hypertension

Cited by 109

Stress-impaired transcription factor expression and insulin secretion in transplanted human islets

Dai, C., Kayton, N. S., Shostak, A., Poffenberger, G., Cyphert, H. A., Aramandla, R., Thompson, C., Papagiannis, I. G., Emfinger, C., Shiota, M., et al. (2016) · Journal of Clinical Investigation

Pancreatic function and diabetesEndoplasmic Reticulum Stress and Disease

Cited by 109

Improving stem cell-derived pancreatic islets using single-cell multiome-inferred regulomes

Zhu, H., Wang, G., Nguyen-Ngoc, K.-V., Kim, D., Miller, M., Goss, G., Kovsky, J., Harrington, A. R., Saunders, D., Melton, R., et al. (2022) · Developmental Cell

Pancreatic function and diabetesSingle-cell and spatial transcriptomics

Cited by 85

Blockade of glucagon signaling prevents or reverses diabetes onset only if residual β-cells persist

Damond, N., Thorel, F., Moyers, J. S., Charron, M. J., Vuguin, P. M., Powers, A. C., & Herrera, P. L. (2016) · eLife

Pancreatic function and diabetesDiabetes and associated disorders

Cited by 74

Redox regulation of m6A methyltransferase METTL3 in β-cells controls the innate immune response in type 1 diabetes

De Jesus, D. F., Zhang, Z., Brown, N. K., Li, X., Xiao, L., Hu, J., Gaffrey, M. J., Fogarty, G., Kahraman, S., Wei, J., et al. (2024) · Nature Cell Biology

Diabetes and associated disordersRNA modifications and cancer

Cited by 56

Redox Regulation of m 6 A Methyltransferase METTL3 in Human β-cells Controls the Innate Immune Response in Type 1 Diabetes

De Jesus, D. F., Zhang, Z., Brown, N. K., Li, X., Gaffrey, M. J., Kahraman, S., Wei, J., Hu, J., Basile, G., Xiao, L., et al. (2023) · Nature Cell Biology

Diabetes and associated disordersRNA modifications and cancer

Cited by 56