Multiplexed In Situ Imaging Mass Cytometry Analysis of the Human Endocrine Pancreas and Immune System in Type 1 Diabetes

R: A Language and Environment for Statistical Computing

R Core Team (2000) · doi:10.32614/r.manuals · Cited by 355,706 · see citing works

<b>lmerTest</b> Package: Tests in Linear Mixed Effects Models

Kuznetsova, A., Brockhoff, P. B., & Christensen, R. H. B. (2017) · Journal of Statistical Software · doi:10.18637/jss.v082.i13 · Cited by 24,346 · see citing works

Diagnosis and Classification of Diabetes Mellitus

American Diabetes Association (2010) · Diabetes Care · doi:10.2337/dc11-s062 · Cited by 14,019 · see citing works

CellProfiler: image analysis software for identifying and quantifying cell phenotypes

Carpenter, A. E., Jones, T. R., Lamprecht, M. R., Clarke, C., Kang, I. H., Friman, O., Guertin, D. A., Chang, J. H., Lindquist, R. A., Moffat, J., et al. (2006) · Genome biology · doi:10.1186/gb-2006-7-10-r100 · Cited by 5,077 · see citing works

Diagnosis and Classification of diabetes mellitus

Rossi, G. (2014) · Diapedia.org eBooks · doi:10.14496/dia..20 · Cited by 3,212 · see citing works

mclust 5: Clustering, Classification and Density Estimation Using Gaussian Finite Mixture Models

Scrucca, L., Fop, M., Murphy, T. B., & Adrian, E. R. (2016) · The R Journal · doi:10.32614/rj-2016-021 · Cited by 2,914 · see citing works

Type 1 diabetes

Atkinson, M. A., Eisenbarth, G. S., & Michels, A. W. (2014) · The Lancet · doi:10.1016/s0140-6736(13)60591-7 · Cited by 2,713 · see citing works

Highly multiplexed imaging of tumor tissues with subcellular resolution by mass cytometry

Giesen, C., Wang, H. A. O., Schapiro, D., Zivanovic, N., Jacobs, A., Hattendorf, B., Schüffler, P. J., Grolimund, D., Buhmann, J. M., Brandt, S., et al. (2014) · Nature Methods · doi:10.1038/nmeth.2869 · Cited by 1,951 · see citing works

Untitled work

Eisenbarth (1986) · doi:10.1056/nejm198605223142106 · Cited by 1,659 · see citing works

Direct evidence for the pancreatic lineage: NGN3+ cells are islet progenitors and are distinct from duct progenitors

Gu, G., Dubauskaite, J., & Melton, D. A. (2002) · Development · doi:10.1242/dev.129.10.2447 · Cited by 1,518 · see citing works

A flexible R package for nonnegative matrix factorization

Gaujoux, R., & Seoighe, C. (2010) · BMC Bioinformatics · doi:10.1186/1471-2105-11-367 · Cited by 1,516 · see citing works

Deep profiling of mouse splenic architecture with CODEX multiplexed imaging

Goltsev, Y., Samusik, N., Kennedy-Darling, J., Bhate, S., Hale, M., Vazquez, G., Black, S., & Nolan, G. P. (2018) · Cell · doi:10.1016/j.cell.2018.07.010 · Cited by 1,501 · cited 1× · see citing works

Type 1 diabetes: new perspectives on disease pathogenesis and treatment

Atkinson, M. A., & Eisenbarth, G. S. (2001) · The Lancet · doi:10.1016/s0140-6736(01)05415-0 · Cited by 1,491 · see citing works

Conversion of adult pancreatic α-cells to β-cells after extreme β-cell loss

Thorel, F., Népote, V., Avril, I., Kohno, K., Desgraz, R., Chera, S., & Herrera, P. L. (2010) · Nature · doi:10.1038/nature08894 · Cited by 1,136 · see citing works

Multiplexed ion beam imaging of human breast tumors

Angelo, M., Bendall, S. C., Finck, R., Hale, M. B., Hitzman, C., Borowsky, A. D., Levenson, R. M., Lowe, J. B., Liu, S. D., Zhao, S., et al. (2014) · Nature Medicine · doi:10.1038/nm.3488 · Cited by 1,108 · see citing works

In Situ Characterization of Autoimmune Phenomena and Expression of HLA Molecules in the Pancreas in Diabetic Insulitis

Bottazzo, G. F., Dean, B. M., McNally, J. M., MacKay, E. H., Swift, P. G. F., & Gamble, D. R. (1985) · New England Journal of Medicine · doi:10.1056/nejm198508083130604 · Cited by 932 · see citing works

Analysis of islet inflammation in human type 1 diabetes

Willcox, A., Richardson, S. J., Bone, A. J., Foulis, A. K., & Morgan, N. G. (2009) · Clinical and Experimental Immunology · doi:10.1111/j.1365-2249.2008.03860.x · Cited by 712 · see citing works

Lack of Glucagon Response to Hypoglycemia in Diabetes: Evidence for an Intrinsic Pancreatic Alpha Cell Defect

Gerich, J. E., Langlois, M., Noacco, C., Karam, J. H., & Forsham, P. H. (1973) · Science · doi:10.1126/science.182.4108.171 · Cited by 688 · see citing works

RNA Sequencing of Single Human Islet Cells Reveals Type 2 Diabetes Genes

Xin, Y., Kim, J., Okamoto, H., Ni, M., Wei, Y., Adler, C., Murphy, A. J., Yancopoulos, G. D., Lin, C., & Gromada, J. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.08.018 · Cited by 677 · see citing works

Demonstration of islet-autoreactive CD8 T cells in insulitic lesions from recent onset and long-term type 1 diabetes patients

Coppieters, K. T., Dotta, F., Amirian, N., Campbell, P. D., Kay, T. W. H., Atkinson, M. A., Roep, B. O., & von Herrath, M. G. (2012) · Journal of Experimental Medicine · doi:10.1084/jem.20111187 · Cited by 672 · see citing works

histoCAT: analysis of cell phenotypes and interactions in multiplex image cytometry data

Schapiro, D., Jackson, H. W., Raghuraman, S., Fischer, J. R., Zanotelli, V. R., Schulz, D., Giesen, C., Catena, R., Varga, Z., & Bodenmiller, B. (2017) · Nature Methods · doi:10.1038/nmeth.4391 · Cited by 643 · see citing works

Multiplexed protein maps link subcellular organization to cellular states

Gut, G., Herrmann, M. D., & Pelkmans, L. (2018) · Science · doi:10.1126/science.aar7042 · Cited by 510 · see citing works

New Perspectives on the Microvasculature of the Islets of Langerhans in the Rat

Bonner‐Weir, S., & Orci, L. (1982) · Diabetes · doi:10.2337/diab.31.10.883 · Cited by 482 · see citing works

Epigenomic plasticity enables human pancreatic α to β cell reprogramming

Bramswig, N. C., Everett, L. J., Schug, J., Dorrell, C., Liu, C., Luo, Y., Streeter, P. R., Naji, A., Grompe, M., & Kaestner, K. H. (2013) · Journal of Clinical Investigation · doi:10.1172/jci66514 · Cited by 402 · see citing works

Mononuclear cell infiltration and its relation to the expression of major histocompatibility complex antigens and adhesion molecules in pancreas biopsy specimens from newly diagnosed insulin-dependent diabetes mellitus patients.

Itoh, N., Hanafusa, T., Miyazaki, A., Miyagawa, J.-I., Yamagata, K., Yamamoto, K., Waguri, M., Imagawa, A., Tamura, S., & Inada, M. (1993) · Journal of Clinical Investigation · doi:10.1172/jci116835 · Cited by 344 · see citing works

The Pathogenesis and Natural History of Type 1 DiabetesPreprint

Atkinson, M. A. (2012) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a007641 · Cited by 318 · see citing works

Autoantibodies in Diabetes

Pihoker, C., Gilliam, L. K., Hampe, C. S., & Lernmark, Å. (2005) · Diabetes · doi:10.2337/diabetes.54.suppl_2.s52 · Cited by 305 · see citing works

Imaging Mass Cytometry

Chang, Q., Ornatsky, O., Siddiqui, I. F. S., Loboda, A., Baranov, V. I., & Hedley, D. W. (2017) · Cytometry Part A · doi:10.1002/cyto.a.23053 · Cited by 305 · see citing works

A Map of Human Type 1 Diabetes Progression by Imaging Mass Cytometry

Damond, N., Engler, S., Zanotelli, V., Schapiro, D., Wasserfall, C., Kusmartseva, I., Nick, H., Thorel, F., Herrera, P., Atkinson, M., et al. (2019) · Cell Metabolism · doi:10.1016/j.cmet.2018.11.014 · Cited by 288 · see citing works

Nkx6.1 Controls a Gene Regulatory Network Required for Establishing and Maintaining Pancreatic Beta Cell Identity

Schaffer, A., Taylor, B., Benthuysen, J., Liu, J., Thorel, F., Yuan, W., Jiao, Y., Kaestner, K., Herrera, P., Magnuson, M., et al. (2013) · PLoS Genetics · doi:10.1371/journal.pgen.1003274 · Cited by 246 · see citing works

Network for Pancreatic Organ Donors with Diabetes (nPOD): developing a tissue biobank for type 1 diabetes

Campbell‐Thompson, M., Wasserfall, C., Kaddis, J., Albanese‐O'Neill, A., Staeva, T., Nierras, C., Moraski, J., Rowe, P., Gianani, R., Eisenbarth, G., et al. (2012) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.2316 · Cited by 236 · see citing works

Virgin Beta Cells Persist throughout Life at a Neogenic Niche within Pancreatic Islets

van der Meulen, T., Mawla, A. M., DiGruccio, M. R., Adams, M. W., Nies, V. J. M., Dólleman, S., Liu, S., Ackermann, A. M., Cáceres, E. L., Hunter, A. E., et al. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.03.017 · Cited by 221 · see citing works

Regional Differences in Islet Distribution in the Human Pancreas - Preferential Beta-Cell Loss in the Head Region in Patients with Type 2 Diabetes

Wang, X., Misawa, R., Zielinski, M. C., Cowen, P., Jo, J., Periwal, V., Ricordi, C., Khan, A., Szust, J., Shen, J., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0067454 · Cited by 213 · see citing works

Blood flow to the rabbit pancreas with special reference to the islets of langerhans

Lifson, N., Kramlinger, K. G., Mayrand, R. R., & Lender, E. J. (1980) · Gastroenterology · doi:10.1016/0016-5085(80)90371-6 · Cited by 212 · see citing works

α Cell Function and Gene Expression Are Compromised in Type 1 Diabetes

Briššová, M., Haliyur, R., Saunders, D. C., Shrestha, S., Dai, C., Blodgett, D. M., Bottino, R., Campbell‐Thompson, M., Aramandla, R., Poffenberger, G., et al. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.02.032 · Cited by 206 · see citing works

The diagnosis of insulitis in human type 1 diabetes

Campbell‐Thompson, M., Atkinson, M. A., Butler, A. E., Chapman, N. M., Frisk, G., Gianani, R., Giepmans, B. N. G., von Herrath, M. G., Hyöty, H., Kay, T. W. H., et al. (2013) · Diabetologia · doi:10.1007/s00125-013-3043-5 · Cited by 187 · see citing works

Loss of β-Cell Identity Occurs in Type 2 Diabetes and Is Associated With Islet Amyloid Deposits

Spijker, H. S., Song, H., Ellenbroek, J. H., Roefs, M. M., Engelse, M. A., Bos, E., Koster, A. J., Rabelink, T. J., HANSEN, B. C., Clark, A., et al. (2015) · Diabetes · doi:10.2337/db14-1752 · Cited by 172 · see citing works

Identification of a lobe in the adult human pancreas rich in pancreatic polypeptide

MALAISSE-LAGAE, F., Stefan, Y., Cox, J., Perrelet, A., & Orci, L. (1979) · Diabetologia · doi:10.1007/bf01236270 · Cited by 161 · see citing works

The Peri-islet Basement Membrane, a Barrier to Infiltrating Leukocytes in Type 1 Diabetes in Mouse and Human

Korpos, É., Kadri, N., Kappelhoff, R., Wegner, J., Overall, C. M., Weber, E., Holmberg, D., Cardell, S., & Sorokin, L. M. (2012) · Diabetes · doi:10.2337/db12-0432 · Cited by 161 · see citing works

Single-Cell Mass Cytometry Analysis of the Human Endocrine Pancreas

Wang, Y. J., Golson, M. L., Schug, J., Traum, D., Liu, C., Vivek, K., Dorrell, C., Naji, A., Powers, A. C., Chang, K., et al. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.09.007 · Cited by 157 · see citing works

Extracellular Matrix Components in the Pathogenesis of Type 1 Diabetes

Bogdani, M., Korpos, É., Simeonovic, C. J., Parish, C. R., Sorokin, L. M., & Wight, T. N. (2014) · Current Diabetes Reports · doi:10.1007/s11892-014-0552-7 · Cited by 126 · see citing works

GABA and Artesunate Do Not Induce Pancreatic α-to-β Cell Transdifferentiation In Vivo

Ackermann, A. M., Moss, N., & Kaestner, K. H. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2018.07.002 · Cited by 115 · see citing works

Type 1 Diabetes Development Requires Both CD4+ and CD8+ T cells and Can Be Reversed by Non-Depleting Antibodies Targeting Both T Cell Populations

Phillips, J. M., Parish, N. M., Bland, C., Sawyer, Y., Peña, H. D. L., & Cooke, A. (2009) · The Review of Diabetic Studies · doi:10.1900/rds.2009.6.97 · Cited by 110 · see citing works

First quantitative high-throughput screen in zebrafish identifies novel pathways for increasing pancreatic β-cell mass

Wang, G., Rajpurohit, S. K., Delaspre, F., Walker, S. L., White, D. T., Ceasrine, A. M., Kuruvilla, R., Li, R., Shim, J. S., Liu, J. O., et al. (2015) · eLife · doi:10.7554/elife.08261 · Cited by 96 · see citing works

Severe acute pancreatitis after percutaneous biopsy of the pancreas

Mueller, P. R., Miketic, L. M., Simeone, J. F., Silverman, S., Saini, S., WITTENBERG, J., Pf, H., Steiner, E., & Bh, F. (1988) · American Journal of Roentgenology · doi:10.2214/ajr.151.3.493 · Cited by 88 · see citing works

The central role of antigen presentation in islets of Langerhans in autoimmune diabetes

Calderón, B., Carrero, J. A., & Unanue, E. R. (2013) · Current Opinion in Immunology · doi:10.1016/j.coi.2013.10.011 · Cited by 50 · see citing works

Beta-cell destruction and preservation in childhood and adult onset type 1 diabetes

Poudel, A., Savari, O., Striegel, D. A., Periwal, V., Taxy, J. B., Millis, J. M., Witkowski, P., Atkinson, M. A., & Hara, M. (2015) · Endocrine · doi:10.1007/s12020-015-0534-9 · Cited by 45 · see citing works

The pancreatic polypeptide-rich lobe of the human pancreas: Definitive identification of its derivation from the ventral pancreatic primordium

Stefan, Y., GRASSO, S. G., Perrelet, A., & Orci, L. (1982) · Diabetologia · doi:10.1007/bf01271177 · Cited by 39 · see citing works

Characterization of Antibodies to Products of Proinsulin Processing Using Immunofluorescence Staining of Pancreas in Multiple Species

Asadi, A., Bruin, J. E., & Kieffer, T. J. (2015) · Journal of Histochemistry & Cytochemistry · doi:10.1369/0022155415576541 · Cited by 35 · see citing works

Pancreatic biopsies in type 1 diabetes: revisiting the myth of Pandora’s box

Atkinson, M. A. (2014) · Diabetologia · doi:10.1007/s00125-013-3159-7 · Cited by 34 · see citing works

Type 1 diabetes mellitus as a disease of the β-cell (do not blame the immune system?)

Roep, B. O., Thomaidou, S., van Tienhoven, R., & Zaldumbide, A. (2020) · Nature Reviews Endocrinology · doi:10.1038/s41574-020-00443-4 · Cited by 646 · see citing works

Spatially Resolved Mass Spectrometry at the Single Cell: Recent Innovations in Proteomics and Metabolomics

Taylor, M. J., Lukowski, J. K., & Anderton, C. (2021) · Journal of the American Society for Mass Spectrometry · doi:10.1021/jasms.0c00439 · Cited by 300 · see citing works

A Map of Human Type 1 Diabetes Progression by Imaging Mass Cytometry

Damond, N., Engler, S., Zanotelli, V., Schapiro, D., Wasserfall, C., Kusmartseva, I., Nick, H., Thorel, F., Herrera, P., Atkinson, M., et al. (2019) · Cell Metabolism · doi:10.1016/j.cmet.2018.11.014 · Cited by 288 · see citing works

Single-cell multi-omics analysis of human pancreatic islets reveals novel cellular states in type 1 diabetes

Fasolino, M., Schwartz, G. W., Patil, A. R., Mongia, A., Golson, M. L., Wang, Y. J., Morgan, A. R., Liu, C., Schug, J., Liu, J., et al. (2022) · Nature Metabolism · doi:10.1038/s42255-022-00531-x · Cited by 223 · see citing works

Immune monitoring using mass cytometry and related high-dimensional imaging approaches

Hartmann, F. J., & Bendall, S. C. (2019) · Nature Reviews Rheumatology · doi:10.1038/s41584-019-0338-z · Cited by 203 · see citing works

Tumor-infiltrating mast cells are associated with resistance to anti-PD-1 therapy

Somasundaram, R., Connelly, T., Choi, R., Choi, H., Samarkina, A., Li, L., Gregorio, E., Chen, Y., Thakur, R., Abdel‐Mohsen, M., et al. (2021) · Nature Communications · doi:10.1038/s41467-020-20600-7 · Cited by 187 · see citing works

NIH Initiative to Improve Understanding of the Pancreas, Islet, and Autoimmunity in Type 1 Diabetes: The Human Pancreas Analysis Program (HPAP)

Kaestner, K. H., Powers, A. C., Naji, A., & Atkinson, M. A. (2019) · Diabetes · doi:10.2337/db19-0058 · Cited by 178 · see citing works

Mass Cytometry Imaging for the Study of Human Diseases—Applications and Data Analysis Strategies

Baharlou, H., Canete, N. P., Cunningham, A. L., Harman, A. N., & Patrick, E. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02657 · Cited by 176 · see citing works

Autoreactive CD8+ T cell exhaustion distinguishes subjects with slow type 1 diabetes progression

Wiedeman, A. E., Muir, V. S., Rosasco, M. G., DeBerg, H. A., Presnell, S., Haas, B., Dufort, M. J., Speake, C., Greenbaum, C. J., Serti, E., et al. (2019) · Journal of Clinical Investigation · doi:10.1172/jci126595 · Cited by 168 · see citing works

Type 1 diabetes mellitus: much progress, many opportunities

Powers, A. C. (2021) · Journal of Clinical Investigation · doi:10.1172/jci142242 · Cited by 154 · see citing works

Single-cell RNA sequencing of murine islets shows high cellular complexity at all stages of autoimmune diabetes

Zakharov, P. N., Hu, H., Wan, X., & Unanue, E. R. (2020) · Journal of Experimental Medicine · doi:10.1084/jem.20192362 · Cited by 149 · see citing works

The physiological role of β-cell heterogeneity in pancreatic islet function

Benninger, R. K. P., & Kravets, V. V. (2021) · Nature Reviews Endocrinology · doi:10.1038/s41574-021-00568-0 · Cited by 136 · see citing works

SEAM is a spatial single nuclear metabolomics method for dissecting tissue microenvironment

Yuan, Z., Zhou, Q., Cai, L., Pan, L., Sun, W., Qumu, S., Yu, S., Feng, J., Zhao, H., Zheng, Y., et al. (2021) · Nature Methods · doi:10.1038/s41592-021-01276-3 · Cited by 133 · see citing works

The pathogenic “symphony” in type 1 diabetes: A disorder of the immune system, β cells, and exocrine pancreas

Atkinson, M. A., & Mirmira, R. G. (2023) · Cell Metabolism · doi:10.1016/j.cmet.2023.06.018 · Cited by 135 · see citing works

Organisation of the human pancreas in health and in diabetes

Atkinson, M., Campbell-Thompson, M., Kusmartseva, I., & Kaestner, K. (2020) · Diabetologia · doi:10.1007/s00125-020-05203-7 · Cited by 118 · see citing works

Engineering islets from stem cells for advanced therapies of diabetes

Siehler, J., Blöchinger, A. K., Meier, M., & Lickert, H. (2021) · Nature Reviews Drug Discovery · doi:10.1038/s41573-021-00262-w · Cited by 125 · see citing works

Partners in Crime: Beta-Cells and Autoimmune Responses Complicit in Type 1 Diabetes Pathogenesis

Toren, E., Burnette, K., Banerjee, R. R., Hunter, C. S., & Tse, H. M. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.756548 · Cited by 110 · see citing works

Identification of cell types in multiplexed in situ images by combining protein expression and spatial information using CELESTA

Zhang, W., Li, I., Reticker-Flynn, N. E., Good, Z., Chang, S., Samusik, N., Saumyaa, S., Li, Y., Zhou, X., Liang, R., et al. (2022) · Nature Methods · doi:10.1038/s41592-022-01498-z · Cited by 108 · see citing works

Tissue-Resident Memory T Cells Mediate Immune Homeostasis in the Human Pancreas Through the PD-1/PD-L1 Pathway

Weisberg, S. P., Carpenter, D. J., Chait, M., Dogra, P., Gartrell, R. D., Chen, A., Campbell, S., Liu, W., Saraf, P., Snyder, M. E., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.11.056 · Cited by 102 · see citing works

Functional changes in beta cells during ageing and senescence

Aguayo‐Mazzucato, C. (2020) · Diabetologia · doi:10.1007/s00125-020-05185-6 · Cited by 106 · see citing works

Nano-DESI Mass Spectrometry Imaging of Proteoforms in Biological Tissues with High Spatial Resolution

Yang, M.-X., Unsihuay, D., Hu, H., Meke, F. N., Qu, Z.-H., Zhang, Z.-Y., & Laskin, J. (2023) · Analytical Chemistry · doi:10.1021/acs.analchem.2c04795 · Cited by 78 · see citing works

Spatial-omics: Novel approaches to probe cell heterogeneity and extracellular matrix biology

Bingham, G. C., Lee, F., Naba, A., & Barker, T. H. (2020) · Matrix Biology · doi:10.1016/j.matbio.2020.04.004 · Cited by 92 · see citing works

Multiplexed imaging of immune cells in staged multiple sclerosis lesions by mass cytometry

Ramaglia, V., Sheikh‐Mohamed, S., Legg, K., Park, C., Rojas, O. L., Zandee, S., Fu, F., Ornatsky, O., Swanson, E. C., Pitt, D., et al. (2019) · eLife · doi:10.7554/elife.48051 · Cited by 82 · see citing works

Large-scale electron microscopy database for human type 1 diabetes

de Boer, P., Pirozzi, N. M., Wolters, A. H. G., Kuipers, J., Kusmartseva, I., Atkinson, M. A., Campbell‐Thompson, M., & Giepmans, B. N. G. (2020) · Nature Communications · doi:10.1038/s41467-020-16287-5 · Cited by 81 · see citing works

The Human Islet: Mini-Organ With Mega-Impact

Walker, J. T., Saunders, D. C., Briššová, M., & Powers, A. C. (2021) · Endocrine Reviews · doi:10.1210/endrev/bnab010 · Cited by 80 · see citing works

Understanding islet dysfunction in type 2 diabetes through multidimensional pancreatic phenotyping: The Human Pancreas Analysis Program

Shapira, S. N., Naji, A., Atkinson, M. A., Powers, A. C., & Kaestner, K. H. (2022) · Cell Metabolism · doi:10.1016/j.cmet.2022.09.013 · Cited by 76 · see citing works

Multimodal Single‐Cell Analyses Outline the Immune Microenvironment and Therapeutic Effectors of Interstitial Cystitis/Bladder Pain Syndrome

Su, F., Zhang, W., Meng, L., Zhang, W., Liu, X., Liu, X., Chen, M., Zhang, Y., & Xiao, F. (2022) · Advanced Science · doi:10.1002/advs.202106063 · Cited by 70 · see citing works

Role of the PD-1/PD-L1 Dyad in the Maintenance of Pancreatic Immune Tolerance for Prevention of Type 1 Diabetes

Falcone, M., & Fousteri, G. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.00569 · Cited by 69 · see citing works

IMC-Denoise: a content aware denoising pipeline to enhance Imaging Mass Cytometry

Lu, P., Oetjen, K. A., Bender, D. E., Ruzinova, M. B., Fisher, D. A. C., Shim, K. G., Pachynski, R. K., Brennen, W. N., Oh, S. T., Link, D. C., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-37123-6 · Cited by 68 · see citing works

The beta cell-immune cell interface in type 1 diabetes (T1D)

James, E. A., Joglekar, A. V., Linnemann, A. K., Russ, H. A., & Kent, S. C. (2023) · Molecular Metabolism · doi:10.1016/j.molmet.2023.101809 · Cited by 68 · see citing works

Single-cell analysis of the human pancreas in type 2 diabetes using multi-spectral imaging mass cytometry

Wu, M., Lee, M. Y. Y., Bahl, V., Traum, D., Schug, J., Kusmartseva, I., Atkinson, M. A., Fan, G., & Kaestner, K. H. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.109919 · Cited by 66 · see citing works

Progress and applications of mass cytometry in sketching immune landscapes

Zhang, T., Warden, A. R., Li, Y., & Ding, X. (2020) · Clinical and Translational Medicine · doi:10.1002/ctm2.206 · Cited by 62 · see citing works

α Cell dysfunction in islets from nondiabetic, glutamic acid decarboxylase autoantibody–positive individuals

Doliba, N. M., Rozo, A. V., Roman, J., Qin, W. D., Traum, D., Gao, L., Liu, J., Manduchi, E., Liu, C., Golson, M. L., et al. (2022) · Journal of Clinical Investigation · doi:10.1172/jci156243 · Cited by 61 · see citing works

Crosstalk between Macrophages and Pancreatic β-Cells in Islet Development, Homeostasis and Disease

Cosentino, C., & Regazzi, R. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22041765 · Cited by 60 · see citing works

Highly Multiplexed Image Analysis of Intestinal Tissue Sections in Patients With Inflammatory Bowel Disease

Kondo, A., Ma, S., Lee, M. Y. Y., Ortiz, V., Traum, D., Schug, J., Wilkins, B. J., Terry, N. A., Lee, H., & Kaestner, K. H. (2021) · Gastroenterology · doi:10.1053/j.gastro.2021.08.055 · Cited by 58 · see citing works

Functional architecture of pancreatic islets identifies a population of first responder cells that drive the first-phase calcium response

Kravets, V. V., Dwulet, J. M., Schleicher, W. E., Hodson, D. J., Davis, A. M., Pyle, L., Piscopio, R. A., Sticco-Ivins, M. A., & Benninger, R. K. P. (2022) · PLoS Biology · doi:10.1371/journal.pbio.3001761 · Cited by 61 · see citing works

Spatial proteomics for understanding the tissue microenvironment

Mao, Y., Wang, X., Huang, P., & Tian, R. (2021) · The Analyst · doi:10.1039/d1an00472g · Cited by 53 · see citing works

Different approaches to Imaging Mass Cytometry data analysis

Milosevic, V. (2023) · Bioinformatics Advances · doi:10.1093/bioadv/vbad046 · Cited by 54 · see citing works

Genetic Variation in Type 1 Diabetes Reconfigures the 3D Chromatin Organization of T Cells and Alters Gene Expression

Fasolino, M., Goldman, N., Wang, W.-L., Cattau, B., Zhou, Y., Petrovic, J., Link, V. M., Coté, A., Chandra, A., Silverman, M., et al. (2020) · Immunity · doi:10.1016/j.immuni.2020.01.003 · Cited by 48 · see citing works

Development of a 2-dimensional atlas of the human kidney with imaging mass cytometry

Singh, N., Avigan, Z. M., Kliegel, J. A., Shuch, B. M., Montgomery, R. R., Moeckel, G. W., & Cantley, L. G. (2019) · JCI Insight · doi:10.1172/jci.insight.129477 · Cited by 49 · see citing works

Islet sympathetic innervation and islet neuropathology in patients with type 1 diabetes

Campbell-Thompson, M., Butterworth, E., Boatwright, J., Nair, M. A., Nasif, L., Nasif, K., Revell, A., Riva, A., Mathews, C., Gerling, I., et al. (2021) · Scientific Reports · doi:10.1038/s41598-021-85659-8 · Cited by 41 · see citing works

CD16+CD163+ monocytes traffic to sites of inflammation during necrotizing enterocolitis in premature infants

Olaloye, O. O., Liu, P., Toothaker, J. M., McCourt, B. T., McCourt, C. C., Xiao, J., Prochaska, E. C., Shaffer, S., Werner, L., Gringauz, J., et al. (2021) · The Journal of Experimental Medicine · doi:10.1084/jem.20200344 · Cited by 49 · see citing works

Novel Techniques and Future Perspective for Investigating Critical-Size Bone Defects

Huang, E. E., Zhang, N., Shen, H., Li, X., Maruyama, M., Utsunomiya, T., Gao, Q., Guzman, R. A., & Goodman, S. B. (2022) · Bioengineering · doi:10.3390/bioengineering9040171 · Cited by 49 · see citing works

Macrophage polarization and signaling in diabetic kidney disease: a catalyst for disease progression

Youssef, N., Noureldein, M. H., Riachi, M. E., Haddad, A., & Eid, A. A. (2023) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00266.2023 · Cited by 48 · see citing works

Islet-Resident Dendritic Cells and Macrophages in Type 1 Diabetes: In Search of Bigfoot’s Print

Zirpel, H., & Roep, B. O. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.666795 · Cited by 44 · see citing works

Semi‐automated background removal limits data loss and normalizes imaging mass cytometry data

Ijsselsteijn, M. E., Somarakis, A., Lelieveldt, B. P. F., Höllt, T., & de Miranda, N. F. C. C. (2021) · Cytometry Part A · doi:10.1002/cyto.a.24480 · Cited by 46 · see citing works

Systematic immune cell dysregulation and molecular subtypes revealed by single-cell RNA-seq of subjects with type 1 diabetes

Honardoost, M. A., Adinatha, A., Schmidt, F., Ranjan, B., Ghaeidamini, M., Rayan, N. A., Lim, M. G. L., Joanito, I., Lin, Q. X. X., Rajagopalan, D., et al. (2024) · Genome Medicine · doi:10.1186/s13073-024-01300-z · Cited by 43 · see citing works

Exploiting Single-Cell Tools in Gene and Cell Therapy

Bode, D., Cull, A. H., Rubio-Lara, J. A., & Kent, D. G. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.702636 · Cited by 43 · see citing works

β-Cell Dysfunction, Hepatic Lipid Metabolism, and Cardiovascular Health in Type 2 Diabetes: New Directions of Research and Novel Therapeutic Strategies

Al-Mrabeh, A. H. (2021) · Biomedicines · doi:10.3390/biomedicines9020226 · Cited by 42 · see citing works

Islet–immune interactions in type 1 diabetes: the nexus of beta cell destruction

Peters, L. D., Posgai, A., & Brusko, T. (2019) · Clinical and Experimental Immunology · doi:10.1111/cei.13349 · Cited by 39 · see citing works

A 34-Marker Panel for Imaging Mass Cytometric Analysis of Human Snap-Frozen Tissue

Guo, N., van Unen, V., Ijsselsteijn, M. E., Ouboter, L. F., Jong, A. E. V. D. M., Lopes, S. M. C. D. S., de Miranda, N. F. C. C., Koning, F., & Li, N. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01466 · Cited by 38 · see citing works

Determinants and dynamics of pancreatic islet architecture

Adams, M. T., & Blum, B. (2022) · Islets · doi:10.1080/19382014.2022.2030649 · Cited by 40 · see citing works

Highly multiplexed 2-dimensional imaging mass cytometry analysis of HBV-infected liver

Traum, D., Wang, Y. J., Schwarz, K. B., Schug, J., Wong, D., Janssen, H. L. A., Terrault, N. A., Khalili, M., Wahed, A. S., Murray, K. F., et al. (2021) · JCI Insight · doi:10.1172/jci.insight.146883 · Cited by 37 · see citing works

Pericyte dysfunction and impaired vasomotion are hallmarks of islets during the pathogenesis of type 1 diabetes

Gonçalves, L. M., Qadir, M. M. F., Boulina, M. E., Makhmutova, M., Pereira, E., & Almaça, J. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.112913 · Cited by 36 · see citing works

The pathophysiology, presentation and classification of Type 1 diabetes

Aamodt, K. I., & Powers, A. C. (2025) · Diabetes Obesity and Metabolism · doi:10.1111/dom.16628 · Cited by 34 · see citing works

The use and limitations of single‐cell mass cytometry for studying human microglia function

Fernández‐Zapata, C., Leman, J. K. H., Priller, J., & Böttcher, C. (2020) · Brain Pathology · doi:10.1111/bpa.12909 · Cited by 34 · see citing works

Clinical and research applications of multiplexed immunohistochemistry and in situ hybridization

McGinnis, L. M., Ibarra-Lopez, V., Rost, S., & Ziai, J. M. (2021) · The Journal of Pathology · doi:10.1002/path.5663 · Cited by 32 · see citing works

Multiplexed Imaging Mass Cytometry Analysis Characterizes the Vascular Niche in Pancreatic Cancer

Sussman, J., Kim, N., Kemp, S. B., Traum, D., Katsuda, T., Kahn, B., Xu, J., Kim, I., Eskandarian, C., Delman, D., et al. (2024) · Cancer Research · doi:10.1158/0008-5472.can-23-2352 · Cited by 32 · see citing works

Molecular Footprints of the Immune Assault on Pancreatic Beta Cells in Type 1 Diabetes

Colli, M. L., Szymczak, F., & Eizirik, D. L. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.568446 · Cited by 31 · see citing works

β-cell mitochondria in diabetes mellitus: a missing puzzle piece in the generation of hPSC-derived pancreatic β-cells?

Diané, A., Al-Shukri, N. A., Mu-u-min, R., & Al-Siddiqi, H. (2022) · Journal of Translational Medicine · doi:10.1186/s12967-022-03327-5 · Cited by 34 · see citing works

Beta Cell Therapies for Preventing Type 1 Diabetes: From Bench to Bedside

Brawerman, G. M., & Thompson, P. J. (2020) · Biomolecules · doi:10.3390/biom10121681 · Cited by 28 · see citing works

Time for a paradigm shift in treating type 1 diabetes mellitus: coupling inflammation to islet regeneration

Cobo‐Vuilleumier, N., & Gauthier, B. R. (2020) · Metabolism · doi:10.1016/j.metabol.2020.154137 · Cited by 28 · see citing works

Modeling type 1 diabetes progression using machine learning and single-cell transcriptomic measurements in human islets

Patil, A. R., Schug, J., Liu, C., Lahori, D., Descamps, H. C., Naji, A., Kaestner, K. H., Faryabi, R. B., & Vahedi, G. (2024) · Cell Reports Medicine · doi:10.1016/j.xcrm.2024.101535 · Cited by 27 · see citing works

Unravelling the heterogeneity and dynamic relationships of tumor-infiltrating T cells by single-cell RNA sequencing analysis

Yu, X., Zhang, L., Chaudhry, A., Rapaport, A. S., & Ouyang, W. (2020) · Journal of Leukocyte Biology · doi:10.1002/jlb.6mr0320-234r · Cited by 26 · see citing works

Diabetes: Concepts of β-Cell Organ Dysfunction and Failure Would Lead to Earlier Diagnoses and Prevention

Charles, M. A., & Leslie, R. D. (2021) · Diabetes · doi:10.2337/dbi21-0012 · Cited by 27 · see citing works

Multiparametric Tissue Characterization Utilizing the Cellular Metallome and Immuno-Mass Spectrometry Imaging

Schaier, M., Theiner, S., Baier, D., Braun, G., Berger, W., & Koellensperger, G. (2023) · JACS Au · doi:10.1021/jacsau.2c00571 · Cited by 27 · see citing works

Immune perturbations in human pancreas lymphatic tissues prior to and after type 1 diabetes onset

Golden, G. J., Wu, V. H., Hamilton, J. T., Amses, K. R., Shapiro, M. R., Japp, A. S., Liu, C., Pampena, M. B., Kuri-Cervantes, L., Knox, J. J., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-59626-0 · Cited by 25 · see citing works

Multifunctional hydrolysates from kenaf (Hibiscus cannabinus L.) seed protein with high antihypertensive activity in vitro and in vivo

Zaharuddin, N. D., Hanafi, M. A., Chay, S. Y., Hussin, F. S., Auwal, S. M., Zarei, M., Sarbini, S. R., Ibadullah, W. Z. W., Karim, R., & Saari, N. (2020) · Journal of Food Measurement & Characterization · doi:10.1007/s11694-020-00663-2 · Cited by 25 · see citing works

Dice-XMBD: Deep Learning-Based Cell Segmentation for Imaging Mass Cytometry

Xiao, X., Qiao, Y., Jiao, Y., Fu, N., Yang, W., Wang, L., Yu, R., & Han, J. (2021) · Frontiers in Genetics · doi:10.3389/fgene.2021.721229 · Cited by 25 · see citing works

SPF: A spatial and functional data analytic approach to cell imaging data

Vu, T., Wrobel, J., Bitler, B. G., Schenk, E. L., Jordan, K. R., & Ghosh, D. (2022) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1009486 · Cited by 25 · see citing works

From immunohistological to anatomical alterations of human pancreas in type 1 diabetes: New concepts on the stage

Nigi, L., Maccora, C., Dotta, F., & Sebastiani, G. (2019) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.3264 · Cited by 24 · see citing works

β Cells Operate Collectively to Help Maintain Glucose Homeostasis

Boris Podobnik, A., Korošak, D., Klemen, M. S., Stožer, A., Dolenšek, J., Rupnik, M. S., Ivanov, P. C., Holme, P., & Jusup, M. (2020) · Biophysical Journal · doi:10.1016/j.bpj.2020.04.005 · Cited by 22 · see citing works

Quantitative immuno-mass spectrometry imaging of skeletal muscle dystrophin

Bishop, D., Westerhausen, M. T., Barthélémy, F., Lockwood, T. E., Cole, N., Gibbs, E. M., Crosbie, R. H., Nelson, S. F., Miceli, M. C., Doble, P., et al. (2021) · Scientific Reports · doi:10.1038/s41598-020-80495-8 · Cited by 24 · see citing works

Functional architecture of the pancreatic islets reveals first responder cells which drive the first-phase [Ca 2+ ] responsePreprint

Kravets, V. V., Dwulet, J. M., Schleicher, W. E., Hodson, D. J., Davis, A. M., Pyle, L., Piscopio, R. A., Sticco-Ivins, M. A., & Benninger, R. K. P. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.12.22.424082 · Cited by 24 · see citing works

Interactions between islets and regulatory immune cells in health and type 1 diabetes

Budd, M. A., Monajemi, M., Colpitts, S. J., Crome, S. Q., Verchere, C. B., & Levings, M. K. (2021) · Diabetologia · doi:10.1007/s00125-021-05565-6 · Cited by 23 · see citing works

Insulitis in human type 1 diabetes: lessons from an enigmatic lesion

Morgan, N. G. (2024) · European Journal of Endocrinology · doi:10.1093/ejendo/lvae002 · Cited by 23 · see citing works

Synovial biopsies in inflammatory arthritis: precision medicine in rheumatoid arthritis

Small, A., & Wechalekar, M. D. (2019) · Expert Review of Molecular Diagnostics · doi:10.1080/14737159.2020.1707671 · Cited by 23 · see citing works

Mass Cytometry Studies of Patients With Autoimmune Endocrine Diseases Reveal Distinct Disease-Specific Alterations in Immune Cell Subsets

Magnusson, L., Barcenilla, H., Pihl, M., Bensing, S., Espes, D., Carlsson, P., & Casas, R. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00288 · Cited by 23 · see citing works

3D imaging of human pancreas suggests islet size and endocrine composition influence their loss in type 1 diabetes

Rippa, A., Posgai, A. L., Currlin, S., Brusko, M., Williams, M. D., Kaddis, J. S., Kusmartseva, I., Wasserfall, C. H., Campbell‐Thompson, M., & Atkinson, M. A. (2025) · Nature Communications · doi:10.1038/s41467-025-66198-6 · Cited by 22 · see citing works

Evidence of islet CADM1-mediated immune cell interactions during human type 1 diabetes

Sona, C., Yeh, Y., Patsalos, A., Halász, L., Yan, X., Kononenko, N. L., Nagy, L., & Poy, M. N. (2022) · JCI Insight · doi:10.1172/jci.insight.153136 · Cited by 22 · see citing works

Exploring pancreatic beta-cell subgroups and their connectivity

Rutter, G. A., Gresch, A., Delgadillo-Silva, L. F., & Benninger, R. K. P. (2024) · Nature Metabolism · doi:10.1038/s42255-024-01097-6 · Cited by 24 · see citing works

Coxsackievirus B Type 4 Infection in β Cells Downregulates the Chaperone Prefoldin URI to Induce a MODY4-like Diabetes via Pdx1 Silencing

Bernard, H., Teijeiro, A., Perez, A. C., Perna, C., Satish, B., Novials, A., Wang, J. P., & Djouder, N. (2020) · Cell Reports Medicine · doi:10.1016/j.xcrm.2020.100125 · Cited by 21 · see citing works

Increased plasmablasts enhance T cell-mediated beta cell destruction and promote the development of type 1 diabetes

Ling, Q., Shen, L., Zhang, W., Qu, D., Wang, H., Wang, B., Liu, Y., Lu, J., Zhu, D., & Bi, Y. (2022) · Molecular Medicine · doi:10.1186/s10020-022-00447-y · Cited by 21 · see citing works

Molecular and functional profiling of human islets: from heterogeneity to human phenotypes

Drigo, R. A. E., Roy, B., & MacDonald, P. E. (2020) · Diabetologia · doi:10.1007/s00125-020-05159-8 · Cited by 20 · see citing works

Gene Signatures of NEUROGENIN3+ Endocrine Progenitor Cells in the Human Pancreas

Yong, H. J., Xie, G., Liu, C., Wang, W., Naji, A., Irianto, J., & Wang, Y. J. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.736286 · Cited by 20 · see citing works

Diabetes as a Pancreatic Microvascular Disease—A Pericytic Perspective

Gonçalves, L. M., Barboza, C. D. A., & Almaça, J. (2024) · Journal of Histochemistry & Cytochemistry · doi:10.1369/00221554241236535 · Cited by 19 · see citing works

The human α cell in health and disease

Pettway, Y. D., Saunders, D. C., & Briššová, M. (2023) · Journal of Endocrinology · doi:10.1530/joe-22-0298 · Cited by 20 · see citing works

The dynamic methylome of islets in health and disease

Avrahami, D., & Kaestner, K. H. (2019) · Molecular Metabolism · doi:10.1016/j.molmet.2019.06.007 · Cited by 19 · see citing works

Towards high throughput and high information coverage: advanced single-cell mass spectrometric techniques

Xu, S., Yang, C., Yan, X., & Liu, H. (2021) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-021-03624-w · Cited by 19 · see citing works

Efferocytic remodelling of pancreatic islet macrophages by limited β-cell death

Zakharov, P. N., Chowdhury, C. S., Peterson, O. J., Barron, B. J., Vomund, A. N., Gorvel, L., Unanue, E. R., Klechevsky, E., Wan, X., & Ravichandran, K. S. (2025) · Nature · doi:10.1038/s41586-025-09560-4 · Cited by 18 · see citing works

The Immunoregulatory Role of the Signal Regulatory Protein Family and CD47 Signaling Pathway in Type 1 Diabetes

Sharp, R. C., Brown, M. E., Shapiro, M. R., Posgai, A. L., & Brusko, T. M. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.739048 · Cited by 17 · see citing works

Single-Cell Proteomic Analysis Dissects the Complexity of Tumor Microenvironment in Muscle Invasive Bladder Cancer

Feng, C., Wang, X., Tao, Y., Xie, Y., Lai, Z., Li, Z., Hu, J., Tang, S., Pan, L.-X., He, L., et al. (2021) · Cancers · doi:10.3390/cancers13215440 · Cited by 18 · see citing works

Pancreatlas: Applying an Adaptable Framework to Map the Human Pancreas in Health and Disease

Saunders, D. C., Messmer, J., Kusmartseva, I., Beery, M. L., Yang, M., Atkinson, M. A., Powers, A. C., Cartailler, J., & Briššová, M. (2020) · Patterns · doi:10.1016/j.patter.2020.100120 · Cited by 19 · see citing works

Detecting respiratory chain defects in osteoblasts from osteoarthritic patients using imaging mass cytometry

Hipps, D., Dobson, P. F., Warren, C., McDonald, D., Fuller, A., Filby, A. J., Bulmer, D., Laude, A., Russell, O. M., Deehan, D. J., et al. (2022) · Bone · doi:10.1016/j.bone.2022.116371 · Cited by 17 · see citing works

Guidelines for standardizing T-cell cytometry assays to link biomarkers, mechanisms, and disease outcomes in type 1 diabetes

Yang, J. H. M., Ward‐Hartstonge, K. A., Perry, D. J., Blanchfield, J. L., Posgai, A. L., Wiedeman, A. E., Diggins, K., Rahman, A., Tree, T. I. M., Brusko, T. M., et al. (2022) · European Journal of Immunology · doi:10.1002/eji.202049067 · Cited by 16 · see citing works

Highly sensitive and multiplexed mass spectrometric immunoassay techniques and clinical applications

Xu, S., Liu, H., & Bai, Y. (2022) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-022-03945-4 · Cited by 16 · see citing works

GPR109a Regulates Phenotypic and Functional Alterations in Macrophages and the Progression of Type 1 Diabetes

Zhang, Z., Li, J., Zhang, M., Li, B., Pan, X., Dong, X., Pan, L., & Sun, J. T. (2022) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.202200300 · Cited by 16 · see citing works

Footprint of pancreas infiltrating and circulating immune cells throughout type 1 diabetes development

Bruggeman, Y., Martens, P.-J., Sassi, G., Viaene, M., Wasserfall, C. H., Mathieu, C., & Gysemans, C. A. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1275316 · Cited by 16 · see citing works

The many faces of islet antigen‐specific CD8 T cells: clues to clinical outcome in type 1 diabetes

WIEDEMAN, A. E., Speake, C., & Long, S. A. (2021) · Immunology and Cell Biology · doi:10.1111/imcb.12437 · Cited by 16 · see citing works

State‐of‐the‐art microscopy to understand islets of Langerhans: what to expect next?

de Boer, P., & Giepmans, B. N. G. (2021) · Immunology and Cell Biology · doi:10.1111/imcb.12450 · Cited by 16 · see citing works

Multiplexed in Situ Imaging Mass Cytometry Analysis of the Human Endocrine Pancreas and Immune System in Type 1 Diabetes: Part 1

Wang, J. (2018) · Data Archiving and Networked Services (DANS) · doi:10.17632/9b262xmtm9

Multiplexed in Situ Imaging Mass Cytometry Analysis of the Human Endocrine Pancreas and Immune System in Type 1 Diabetes: Part 2

Wang, J. (2018) · Data Archiving and Networked Services (DANS) · doi:10.17632/xbxnfg2zfs

Single-cell analysis of the human pancreas in type 2 diabetes using multi-spectral imaging mass cytometry

Wu, M., Lee, M. Y. Y., Bahl, V., Traum, D., Schug, J., Kusmartseva, I., Atkinson, M. A., Fan, G., & Kaestner, K. H. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.109919 · Cited by 66 · see citing works

A Map of Human Type 1 Diabetes Progression by Imaging Mass Cytometry

Damond, N. (2019) · Data Archiving and Networked Services (DANS) · doi:10.17632/cydmwsfztj

Imaging mass cytometry reveals functional and immunological changes during type 1 diabetes progression in human pancreata

Steenbuck, N., Damond, N., Engler, S., Kusmartseva, I., Posgai, A. L., Drotar, D. M., Williams, M. D., de Souza, N., Brusko, T. M., Brusko, M., et al. (2026) · Nature Metabolism · doi:10.1038/s42255-026-01559-z · Cited by 12 · see citing works