Ivan, Mircea

HIFα Targeted for VHL-Mediated Destruction by Proline Hydroxylation: Implications for O 2 Sensing

Ivan, M., Kondo, K., Yang, H., Kim, W., Valiando, J., Ohh, M., Salic, A., Asara, J. M., Lane, W. S., & Kaelin Jr., W. G. (2001) · Science

Cancer, Hypoxia, and MetabolismUbiquitin and proteasome pathways

Cited by 4,735

Ubiquitination of hypoxia-inducible factor requires direct binding to the β-domain of the von Hippel–Lindau protein

Ohh, M., Park, C. W., Ivan, M., Hoffman, M. A., Kim, T.-Y., Huang, L. E., Pavletich, N., Chau, V., & Kaelin, W. G. (2000) · Nature Cell Biology

Ubiquitin and proteasome pathwaysCancer, Hypoxia, and Metabolism

Cited by 1,577

A MicroRNA Signature of Hypoxia

Kulshreshtha, R., Ferracin, M., Wojcik, S. E., Garzon, R., Alder, H., Agosto-Perez, F. J., Davuluri, R., Liu, C.-G., Croce, C. M., Negrini, M., et al. (2007) · Molecular and Cellular Biology

MicroRNA in disease regulationCancer, Hypoxia, and Metabolism

Cited by 1,055

Structure of an HIF-1α-pVHL Complex: Hydroxyproline Recognition in Signaling

Min, J.-H., Yang, H., Ivan, M., Gertler, F., Kaelin, W. G., & Pavletich, N. P. (2002) · Science

Cancer, Hypoxia, and MetabolismUbiquitin and proteasome pathways

Cited by 765

Biochemical purification and pharmacological inhibition of a mammalian prolyl hydroxylase acting on hypoxia-inducible factor

Ivan, M., Haberberger, T., Gervasi, D. C., Michelson, K. S., Günzler, V., Kondo, K., Yang, H., Sorokina, I., Conaway, R. C., Conaway, J. W., et al. (2002) · Proceedings of the National Academy of Sciences

Cancer, Hypoxia, and MetabolismErythropoietin and Anemia Treatment

Cited by 561

MicroRNA regulation of DNA repair gene expression in hypoxic stress

Crosby, M. E., Kulshreshtha, R., Ivan, M., & Glazer, P. M. (2009) · Cancer Research

MicroRNA in disease regulationCancer, Hypoxia, and Metabolism

Cited by 437

MicroRNA-210 Regulates Mitochondrial Free Radical Response to Hypoxia and Krebs Cycle in Cancer Cells by Targeting Iron Sulfur Cluster Protein ISCU

Favaro, E., Ramachandran, A., McCormick, R., Gee, H., Blancher, C., Crosby, M., Devlin, C., Blick, C., Buffa, F., Li, J.-L., et al. (2010) · PLoS ONE

Cancer, Hypoxia, and MetabolismMicroRNA in disease regulation

Cited by 324

The EGLN-HIF O 2 -Sensing System: Multiple Inputs and Feedbacks

Ivan, M., & Kaelin, W. G. (2017) · Molecular Cell

Cancer, Hypoxia, and MetabolismErythropoietin and Anemia Treatment

Cited by 273

HINCUTs in cancer: Hypoxia-induced noncoding ultraconserved transcripts

Ferdin, J., Nishida, N., Wu, X., Nicoloso, M. S., Shah, M. Y., Devlin, C., Ling, H., Shimizu, M., Kumar, K., Cortez, M. A., et al. (2013) · Cell Death & Differentiation

Cancer-related molecular mechanisms researchCancer, Hypoxia, and Metabolism

Cited by 103

Evidence for a Telomere-Independent “Clock” Limiting RAS Oncogene-Driven Proliferation of Human Thyroid Epithelial Cells

Jones, C. J., Kipling, D., Morris, M., Hepburn, P., Skinner, J., Bounacer, A., Wyllie, F. S., Ivan, M., Bartek, J., Wynford-Thomas, D., et al. (2000) · Molecular and Cellular Biology

Telomeres, Telomerase, and SenescenceProtein Kinase Regulation and GTPase Signaling

Cited by 89