The EGLN-HIF O 2 -Sensing System: Multiple Inputs and Feedbacks
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The EGLN (also called PHD) prolyl hydroxylase enzymes and their canonical targets, the HIFα subunits, represent the core of an ancient oxygen-monitoring machinery used by metazoans. In this review, we highlight recent progress in understanding the overlapping versus specific roles of EGLN enzymes and HIF isoforms and discuss how feedback loops based on recently identified noncoding RNAs introduce additional layers of complexity to the hypoxic response. Based on novel interactions identified upstream and downstream of EGLNs, an integrated network connecting oxygen-sensing functions to metabolic and signaling pathways is gradually emerging with broad therapeutic implications.
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Several noteworthy interactions include KHDRBS1, EGLN2, and BRI3BP.
“Several noteworthy interactions include a regulator of cell cycle progression, KHDRBS1 (ref. 72), the oxygen sensor, EGLN2 (ref. 73), and a stabilizer of p53, BRI3BP74”
From The origins and genetic interactions of KRAS mutations are allele- and tissue-specific (2021) · cites this paper as [73]
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- Authors
- Ivan, M., & Kaelin, W. G.
- Affiliations
- Indiana University Indianapolis (US)
- Brigham and Women's Hospital (US)
- Corresponding author
- Ivan, Mircea
- Venue
- Molecular Cell
- Publisher
- Elsevier BV
- Published
- 2017-06
- Volume
- 66
- Issue
- 6
- Pages
- 772-779
- ISSN
- 1097-2765 (ISSN-L)
- PMC
- PMC5613951
- OpenAlex
- W2624675086
- Cited by
- 273
- References
- 77
- Citations by year
- 2026: 23 · 2025: 25 · 2024: 48 · 2023: 27 · 2022: 36 · 2021: 31 · 2020: 36 · 2019: 22 · 2018: 19 · 2017: 4
- FWCI
- 2.25
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Molecular Cell (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Purdue University Indianapolis (Indiana University) (submittedVersion)
- PMC
- Funders
- Howard Hughes Medical Institute
- Breast Cancer Research Foundation
- NIH (R35CA210068, P50CA165962, P50CA101942, R01CA155332)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
- Health Sciences › Medicine › Hematology › Erythropoietin and Anemia Treatment
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Kruppel-like factors research
- Keywords
- oxygen sensing, hypoxia response, non-coding RNA, feedback loops, metabolic pathways, signaling pathways, therapeutic target
- MeSH terms
- Endoglin, Tumor Hypoxia, Endothelial PAS Domain-Containing Protein 1, Adaptation, Physiological, Animals, Antineoplastic Agents, Humans, Neoplasms, Oxygen, Signal Transduction, RNA, Untranslated, Feedback, Physiological, Basic Helix-Loop-Helix Proteins, Hypoxia-Inducible Factor 1, alpha Subunit
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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