Hengstler, Jan G.

Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME

Godoy, P., Hewitt, N. J., Albrecht, U., Andersen, M. E., Ansari, N., Bhattacharya, S., Bode, J. G., Bolleyn, J., Borner, C., Böttger, J., et al. (2013) · Archives of Toxicology

Drug-Induced Hepatotoxicity and ProtectionLiver physiology and pathology

Cited by 1,280

Primary hepatocytes: current understanding of the regulation of metabolic enzymes and transporter proteins, and pharmaceutical practice for the use of hepatocytes in metabolism, enzyme induction, transporter, clearance, and hepatotoxicity studies

Hewitt, N. J., Gómez Lechón, M. J., Houston, J. B., Hallifax, D., Brown, H. S., Maurel, P., Kenna, J. G., Gustavsson, L., Lohmann, C., Skonberg, C., et al. (2007) · Drug Metabolism Reviews

Pharmacogenetics and Drug MetabolismDrug-Induced Hepatotoxicity and Protection

Cited by 735

Adverse outcome pathways: opportunities, limitations and open questions

Leist, M., Ghallab, A., Graepel, R., Marchan, R., Hassan, R., Bennekou, S. H., Limonciel, A., Vinken, M., Schildknecht, S., Waldmann, T., et al. (2017) · Archives of Toxicology

Animal testing and alternativesAgricultural safety and regulations

Cited by 394

Rab5 is necessary for the biogenesis of the endolysosomal system in vivo

Zeigerer, A., Gilleron, J., Bogorad, R. L., Marsico, G., Nonaka, H., Seifert, S., Epstein-Barash, H., Kuchimanchi, S., Peng, C. G., Ruda, V. M., et al. (2012) · Nature

Cellular transport and secretionAutophagy in Disease and Therapy

Cited by 362

Biomarker discovery in non-small cell lung cancer: integrating gene expression profiling, meta-analysis, and tissue microarray validation.

Botling, J., Edlund, K., Lohr, M., Hellwig, B., Holmberg, L., Lambe, M., Berglund, A., Ekman, S., Bergqvist, M., Pontén, F., et al. (2013) · Clinical Cancer Research

Lung Cancer Research StudiesBreast Cancer Treatment Studies

Cited by 359

Functional integration of hepatocytes derived from human mesenchymal stem cells into mouse livers

Aurich, I., Mueller, L. P., Aurich, H., Luetzkendorf, J., Tisljar, K., Dollinger, M. M., Schormann, W., Walldorf, J., Hengstler, J. G., Fleig, W. E., et al. (2007) · Gut

Mesenchymal stem cell researchLiver physiology and pathology

Cited by 314

The ascending pathophysiology of cholestatic liver disease

Jansen, P. L. M., Ghallab, A., Vartak, N., Reif, R., Schaap, F. G., Hampe, J., & Hengstler, J. G. (2017) · Hepatology

Liver Diseases and ImmunityDrug Transport and Resistance Mechanisms

Cited by 301

Manufactured nanomaterials: categorization and approaches to hazard assessment

Gebel, T., Foth, H., Damm, G., Freyberger, A., Kramer, P.-J., Lilienblum, W., Röhl, C., Schupp, T., Weiss, C., Wollin, K.-M., et al. (2014) · Archives of Toxicology

Nanoparticles: synthesis and applicationsGraphene and Nanomaterials Applications

Cited by 137

Hepatocyte-specific NRF2 activation controls fibrogenesis and carcinogenesis in steatohepatitis

Mohs, A., Otto, T., Schneider, K. M., Peltzer, M., Boekschoten, M., Holland, C. H., Hudert, C. A., Kalveram, L., Wiegand, S., Saez-Rodriguez, J., et al. (2021) · Journal of Hepatology

Genomics, phytochemicals, and oxidative stressLiver Disease Diagnosis and Treatment

Cited by 137

Primary mouse hepatocytes for systems biology approaches: a standardized in vitro system for modelling of signal transduction pathways

Klingmüller, U., Bauer, A., Bohl, S., Nickel, P. J., Breitkopf, K., Dooley, S., Zellmer, S., Kern, C., Merfort, I., Sparna, T., et al. (2006) · IEE Proceedings - Systems Biology

Liver physiology and pathologyGene Regulatory Network Analysis

Cited by 127

3D spherical microtissues and microfluidic technology for multi-tissue experiments and analysis

Kim, J.-Y., Fluri, D. A., Marchan, R., Boonen, K., Mohanty, S., Singh, P., Hammad, S., Landuyt, B., Hengstler, J. G., Kelm, J. M., et al. (2015) · Journal of Biotechnology

3D Printing in Biomedical ResearchMicrofluidic and Capillary Electrophoresis Applications

Cited by 126

Natural killer cells and liver fibrosis

Fasbender, F., Widera, A., Hengstler, J. G., & Watzl, C. (2016) · Frontiers in Immunology

Immune Cell Function and InteractionLiver physiology and pathology

Cited by 118

Intestinal Dysbiosis Amplifies Acetaminophen-Induced Acute Liver Injury

Schneider, K. M., Elfers, C., Ghallab, A., Schneider, C. V., Galvez, E. J. C., Mohs, A., Gui, W., Candels, L. S., Wirtz, T. H., Zuehlke, S., et al. (2021) · Cellular and Molecular Gastroenterology and Hepatology

Drug-Induced Hepatotoxicity and ProtectionGut microbiota and health

Cited by 108

Design Principles of Concentration-Dependent Transcriptome Deviations in Drug-Exposed Differentiating Stem Cells

Waldmann, T., Rempel, E., Balmer, N. V., König, A., Kolde, R., Gaspar, J. A., Henry, M., Hescheler, J., Sachinidis, A., Rahnenführer, J., et al. (2014) · Chemical Research in Toxicology

Pharmacological Effects and Toxicity StudiesCarcinogens and Genotoxicity Assessment

Cited by 106

Bile Microinfarcts in Cholestasis Are Initiated by Rupture of the Apical Hepatocyte Membrane and Cause Shunting of Bile to Sinusoidal Blood

Ghallab, A., Hofmann, U., Sezgin, S., Vartak, N., Hassan, R., Zaza, A., Godoy, P., Schneider, K. M., Guenther, G., Ahmed, Y. A., et al. (2019) · Hepatology

Liver physiology and pathologyLiver Diseases and Immunity

Cited by 101

Sleep-dependent upscaled excitability, saturated neuroplasticity, and modulated cognition in the human brain

Salehinejad, M. A., Ghanavati, E., Reinders, J., Hengstler, J. G., Kuo, M.-F., & Nitsche, M. A. (2022) · eLife

Sleep and Wakefulness ResearchTranscranial Magnetic Stimulation Studies

Cited by 94

Towards improved hepatocyte cultures: Progress and limitations

Ruoß, M., Vosough, M., Königsrainer, A., Nadalin, S., Wagner, S., Sajadian, S., Huber, D., Heydari, Z., Ehnert, S., Hengstler, J. G., et al. (2020) · Food and Chemical Toxicology

Drug-Induced Hepatotoxicity and ProtectionAnimal testing and alternatives

Cited by 77

https://www.altex.org/index.php/altex/article/view/1339

Krebs, A., Waldmann, T., Wilks, M. F., van Vugt-Lussenburg, B. M. A., van der Burg, B., Terron, A., Steger-Hartmann, T., Ruegg, J., Rovida, C., Pedersen, E., et al. (2019) · ALTEX

Animal testing and alternativesAgricultural safety and regulations

Cited by 77

Highlight report: Launch of a large integrated European in vitro toxicology project: EU-ToxRisk

Daneshian, M., Kamp, H., Hengstler, J., Leist, M., & van de Water, B. (2016) · Archives of Toxicology

Animal testing and alternativesImmunotoxicology and immune responses

Cited by 65

Bile canaliculi formation and biliary transport in 3D sandwich-cultured hepatocytes in dependence of the extracellular matrix composition

Deharde, D., Schneider, C., Hiller, T., Fischer, N., Kegel, V., Lübberstedt, M., Freyer, N., Hengstler, J. G., Andersson, T. B., Seehofer, D., et al. (2016) · Archives of Toxicology

Liver physiology and pathologyDrug-Induced Hepatotoxicity and Protection

Cited by 58

HR-MAS NMR Based Quantitative Metabolomics in Breast Cancer

Gogiashvili, M., Nowacki, J., Hergenröder, R., Hengstler, J. G., Lambert, J., & Edlund, K. (2019) · Metabolites

Metabolomics and Mass Spectrometry StudiesAdvanced NMR Techniques and Applications

Cited by 44

Gene Expression–Based Prediction of Neoadjuvant Chemotherapy Response in Early Breast Cancer: Results of the Prospective Multicenter EXPRESSION Trial

Edlund, K., Madjar, K., Lebrecht, A., Aktas, B., Pilch, H., Hoffmann, G., Hofmann, M., Kolberg, H.-C., Boehm, D., Battista, M., et al. (2021) · Clinical Cancer Research

Breast Cancer Treatment StudiesGene expression and cancer classification

Cited by 24

IGF2 mRNA Binding Protein 2 Transgenic Mice Are More Prone to Develop a Ductular Reaction and to Progress Toward Cirrhosis

Czepukojc, B., Abuhaliema, A., Barghash, A., Tierling, S., Naß, N., Simon, Y., Körbel, C., Cadenas, C., van Hul, N., Sachinidis, A., et al. (2019) · Frontiers in Medicine

Liver physiology and pathologyLiver Disease Diagnosis and Treatment

Cited by 20

Design of optimal concentrations for in vitro cytotoxicity experiments

Schürmeyer, L., Peng, C., Albrecht, W., Brecklinghaus, T., Baur, P., Hengstler, J. G., & Schorning, K. (2025) · Archives of Toxicology

Optimal Experimental Design MethodsStatistical Methods in Clinical Trials

Cited by 11