Arnold, Thomas D.

Targeting of αv integrin identifies a core molecular pathway that regulates fibrosis in several organs

Henderson, N. C., Arnold, T. D., Katamura, Y., Giacomini, M. M., Rodriguez, J. D., McCarty, J. H., Pellicoro, A., Raschperger, E., Betsholtz, C., Ruminski, P. G., et al. (2013) · Nature Medicine

Liver physiology and pathologyCell Adhesion Molecules Research

Cited by 866

The α v β 1 integrin plays a critical in vivo role in tissue fibrosis

Reed, N. I., Jo, H., Chen, C., Tsujino, K., Arnold, T. D., DeGrado, W. F., & Sheppard, D. (2015) · Science Translational Medicine

Cell Adhesion Molecules ResearchTGF-β signaling in diseases

Cited by 311

APOE4 impairs the microglial response in Alzheimer’s disease by inducing TGFβ-mediated checkpoints

Yin, Z., Rosenzweig, N., Kleemann, K. L., Zhang, X., Brandão, W., Margeta, M. A., Schroeder, C., Sivanathan, K. N., Silveira, S., Gauthier, C., et al. (2023) · Nature Immunology

Neuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatments

Cited by 202

CNS fibroblasts form a fibrotic scar in response to immune cell infiltration.

Dorrier, C. E., Aran, D., Haenelt, E. A., Sheehy, R. N., Hoi, K. K., Pintarić, L., Chen, Y., Lizama, C. O., Cautivo, K. M., Weiner, G. A., et al. (2021) · Nature Neuroscience

Multiple Sclerosis Research StudiesNeuroinflammation and Neurodegeneration Mechanisms

Cited by 199

Type-I-interferon-responsive microglia shape cortical development and behavior

Escoubas, C. C., Dorman, L. C., Nguyen, P. T., Lagares-Linares, C., Nakajo, H., Anderson, S. R., Barron, J. J., Wade, S. D., Cuevas, B., Vainchtein, I. D., et al. (2024) · Cell

Neuroinflammation and Neurodegeneration MechanismsNeurogenesis and neuroplasticity mechanisms

Cited by 179

A new genetic strategy for targeting microglia in development and disease

McKinsey, G. L., Lizama, C. O., Keown-Lang, A. E., Niu, A., Santander, N., Larpthaveesarp, A., Chee, E., Gonzalez, F. F., & Arnold, T. D. (2020) · eLife

Neuroinflammation and Neurodegeneration MechanismsNeurogenesis and neuroplasticity mechanisms

Cited by 176

LSR/angulin-1 is a tricellular tight junction protein involved in blood–brain barrier formation

Sohet, F., Lin, C., Munji, R. N., Lee, S. Y., Ruderisch, N., Soung, A., Arnold, T. D., Derugin, N., Vexler, Z. S., Yen, F. T., et al. (2015) · Journal of Cell Biology

Barrier Structure and Function StudiesDrug Transport and Resistance Mechanisms

Cited by 139

Pericyte-specific vascular expression of SARS-CoV-2 receptor ACE2 – implications for microvascular inflammation and hypercoagulopathy in COVID-19

He, L., Mäe, M. A., Muhl, L., Sun, Y., Pietilä, R., Nahar, K., Liébanas, E. V., Fagerlund, M. J., Oldner, A., Liu, J., et al. (2020) · bioRxiv (Cold Spring Harbor Laboratory)

COVID-19 Clinical Research StudiesSARS-CoV-2 and COVID-19 Research

Cited by 116

Impaired αVβ8 and TGFβ signaling lead to microglial dysmaturation and neuromotor dysfunction

Arnold, T. D., Lizama, C. O., Cautivo, K. M., Santander, N., Lin, L., Qiu, H., Huang, E. J., Liu, C., Mukouyama, Y.-S., Reichardt, L. F., et al. (2019) · Journal of Experimental Medicine

Neuroinflammation and Neurodegeneration MechanismsNeurogenesis and neuroplasticity mechanisms

Cited by 67

A comparative evaluation of the strengths and potential caveats of the microglial inducible CreER mouse models

Bedolla, A. M., McKinsey, G. L., Ware, K., Santander, N., Arnold, T. D., & Luo, Y. (2024) · Cell Reports

Neuroinflammation and Neurodegeneration MechanismsCRISPR and Genetic Engineering

Cited by 53

Structural and molecular basis of choline uptake into the brain by FLVCR2

Cater, R. J., Mukherjee, D., Gil-Iturbe, E., Erramilli, S. K., Chen, T., Koo, K., Santander, N., Reckers, A., Kloss, B., Gawda, T., et al. (2024) · Nature

Drug Transport and Resistance MechanismsBarrier Structure and Function Studies

Cited by 45

Structural and molecular basis of choline uptake into the brain by FLVCR2

Cater, R. J., Mukherjee, D., Iturbe, E. G., Erramilli, S. K., Chen, T., Koo, K., Grez, N. S., Reckers, A., Kloss, B., Gawda, T., et al. (2023) · Nature

Drug Transport and Resistance MechanismsBarrier Structure and Function Studies

Cited by 45