Cited by 311Cell Adhesion Molecules ResearchTGF-β signaling in diseasesInterstitial Lung Diseases and Idiopathic Pulmonary Fibrosis

The α v β 1 integrin plays a critical in vivo role in tissue fibrosis

Open access
Reed, Nilgun I., Jo, Hyunil, Chen, Chun, Tsujino, Kazuyuki, Arnold, Thomas D., DeGrado, William F., Sheppard, Dean·2015·Science Translational Medicine

Abstract

An α v β 1 inhibitor attenuated pulmonary and liver fibrosis in mouse models.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1126/scitranslmed.aaa5094

Cites

33 of 33 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Small molecule inhibition and antibody blockade of integrin αvβ6 have both been shown to effectively attenuate biliary and non-biliary fibrogenesis with reduced proliferation of cholangiocyte-like progenitor cells and attenuated TGFβ1 activation.

    “Small molecule inhibition and antibody blockade of integrin αvβ6 have both been shown to effectively attenuate biliary and non-biliary fibrogenesis with reduced proliferation of cholangiocyte-like progenitor cells and attenuated TGFβ1 activation.59,60”
  • Mice lacking αvβ6 integrin are protected in mouse models of lung, kidney, and biliary fibrosis.

    “Mice lacking the αvβ6 integrin are protected in mouse models of lung, kidney and biliary fibrosis90,98–102”

    From Fibrosis: from mechanisms to medicines (2020) · cites this paper as [102]

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

1 of the 34 references couldn’t be matched to a known paper.

Cited by

Sorted by citations

Authors
Reed, N. I., Jo, H., Chen, C., Tsujino, K., Arnold, T. D., DeGrado, W. F., & Sheppard, D.
Affiliations
University of California, San Francisco (US)
Corresponding author
  • Reed, Nilgun I.
  • Jo, Hyunil
  • DeGrado, William F.
  • Sheppard, Dean
Venue
Science Translational Medicine
Published
2015-05-20
Volume
7
Issue
288
Pages
288ra79-288ra79
ISSN
  • 1946-6234 (ISSN-L)
  • 1946-6242
OpenAlex
W2159360181
Cited by
311
References
34
Citations by year
2026: 19 · 2025: 27 · 2024: 28 · 2023: 26 · 2022: 26 · 2021: 37 · 2020: 28 · 2019: 28 · 2018: 23 · 2017: 35 · 2016: 26 · 2015: 6 · 2013: 1
FWCI
26.80
Type
journal article
Language
en
Open access
Locations
  • Science Translational Medicine (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
  • eScholarship (California Digital Library) (submittedVersion)
Funders
  • U. S. NIH (HL53949, HL108794)
  • Sandler Foundation
Topics
  • Health Sciences › Medicine › Immunology and Allergy › Cell Adhesion Molecules Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › TGF-β signaling in diseases
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
Keywords
integrin αvβ1, fibrosis, TGF-β1 activation, latency-associated peptide, fibroblast activation, bleomycin-induced lung fibrosis, carbon tetrachloride-induced liver fibrosis, antifibrotic therapy
MeSH terms
Animals, Bleomycin, Cells, Cultured, Fibroblasts, Hydrocarbons, Brominated, Liver, Liver Cirrhosis, Experimental, Lung, Mice, Inbred C57BL, Pulmonary Fibrosis, Drug Design, Signal Transduction, Transforming Growth Factor beta, Receptors, Vitronectin, Mice, Chemical and Drug Induced Liver Injury, Molecular Targeted Therapy

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review