The α v β 1 integrin plays a critical in vivo role in tissue fibrosis
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An α v β 1 inhibitor attenuated pulmonary and liver fibrosis in mouse models.
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Small molecule inhibition and antibody blockade of integrin αvβ6 have both been shown to effectively attenuate biliary and non-biliary fibrogenesis with reduced proliferation of cholangiocyte-like progenitor cells and attenuated TGFβ1 activation.
“Small molecule inhibition and antibody blockade of integrin αvβ6 have both been shown to effectively attenuate biliary and non-biliary fibrogenesis with reduced proliferation of cholangiocyte-like progenitor cells and attenuated TGFβ1 activation.59,60”
From Understanding the cellular interactome of non-alcoholic fatty liver disease (2022) · cites this paper as [60]
Mice lacking αvβ6 integrin are protected in mouse models of lung, kidney, and biliary fibrosis.
“Mice lacking the αvβ6 integrin are protected in mouse models of lung, kidney and biliary fibrosis90,98–102”
From Fibrosis: from mechanisms to medicines (2020) · cites this paper as [102]
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- Authors
- Reed, N. I., Jo, H., Chen, C., Tsujino, K., Arnold, T. D., DeGrado, W. F., & Sheppard, D.
- Affiliations
- University of California, San Francisco (US)
- Corresponding author
- Reed, Nilgun I.
- Jo, Hyunil
- DeGrado, William F.
- Sheppard, Dean
- Venue
- Science Translational Medicine
- Published
- 2015-05-20
- Volume
- 7
- Issue
- 288
- Pages
- 288ra79-288ra79
- ISSN
- 1946-6234 (ISSN-L)
- 1946-6242
- PMC
- PMC4461057
- OpenAlex
- W2159360181
- Cited by
- 311
- References
- 34
- Citations by year
- 2026: 19 · 2025: 27 · 2024: 28 · 2023: 26 · 2022: 26 · 2021: 37 · 2020: 28 · 2019: 28 · 2018: 23 · 2017: 35 · 2016: 26 · 2015: 6 · 2013: 1
- FWCI
- 26.80
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science Translational Medicine (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- U. S. NIH (HL53949, HL108794)
- Sandler Foundation
- Topics
- Health Sciences › Medicine › Immunology and Allergy › Cell Adhesion Molecules Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › TGF-β signaling in diseases
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Keywords
- integrin αvβ1, fibrosis, TGF-β1 activation, latency-associated peptide, fibroblast activation, bleomycin-induced lung fibrosis, carbon tetrachloride-induced liver fibrosis, antifibrotic therapy
- MeSH terms
- Animals, Bleomycin, Cells, Cultured, Fibroblasts, Hydrocarbons, Brominated, Liver, Liver Cirrhosis, Experimental, Lung, Mice, Inbred C57BL, Pulmonary Fibrosis, Drug Design, Signal Transduction, Transforming Growth Factor beta, Receptors, Vitronectin, Mice, Chemical and Drug Induced Liver Injury, Molecular Targeted Therapy
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