Isaacs, John

Frailty and the role of inflammation, immunosenescence and cellular ageing in the very old: Cross-sectional findings from the Newcastle 85+ Study

Collerton, J., Martin-Ruiz, C., Davies, K., Hilkens, C. M., Isaacs, J., Kolenda, C., Parker, C., Dunn, M., Catt, M., Jagger, C., et al. (2012) · Mechanisms of Ageing and Development

Frailty in Older AdultsNutrition and Health in Aging

Cited by 420

Efficacy and safety of secukinumab, a fully human anti-interleukin-17A monoclonal antibody, in patients with moderate-to-severe psoriatic arthritis: a 24-week, randomised, double-blind, placebo-controlled, phase II proof-of-concept trial

McInnes, I. B., Sieper, J., Braun, J., Emery, P., van der Heijde, D., Isaacs, J. D., Dahmen, G., Wollenhaupt, J., Schulze-Koops, H., Kogan, J., et al. (2014) · Annals of the Rheumatic Diseases

Spondyloarthritis Studies and TreatmentsPsoriasis: Treatment and Pathogenesis

Cited by 343

Mechanism of first-dose cytokine-release syndrome by CAMPATH 1-H: involvement of CD16 (FcgammaRIII) and CD11a/CD18 (LFA-1) on NK cells.

Wing, M. G., Moreau, T., Greenwood, J., Smith, R. M., Hale, G., Isaacs, J., Waldmann, H., Lachmann, P. J., & Compston, A. (1996) · Journal of Clinical Investigation

Immune Cell Function and InteractionMonoclonal and Polyclonal Antibodies Research

Cited by 257

CMV seropositivity and T‐cell senescence predict increased cardiovascular mortality in octogenarians: results from the Newcastle 85+ study

Spyridopoulos, I., Martin‐Ruiz, C., Hilkens, C., Yadegarfar, M. E., Isaacs, J., Jagger, C., Kirkwood, T., & von Zglinicki, T. (2016) · Aging Cell

Cytomegalovirus and herpesvirus researchTelomeres, Telomerase, and Senescence

Cited by 133

Effect of tocilizumab on haematological markers implicates interleukin-6 signalling in the anaemia of rheumatoid arthritis.

Isaacs, J. D., Harari, O., Kobold, U., Lee, J. S., & Bernasconi, C. (2013) · Arthritis Research & Therapy

Iron Metabolism and DisordersRheumatoid Arthritis Research and Therapies

Cited by 105

Adrenal Steroidogenesis after B Lymphocyte Depletion Therapy in New-Onset Addison's Disease

Pearce, S. H. S., Mitchell, A. L., Bennett, S., King, P., Chandran, S., Nag, S., Chen, S., Smith, B. R., Isaacs, J. D., & Vaidya, B. (2012) · The Journal of Clinical Endocrinology & Metabolism

Adrenal Hormones and DisordersHormonal Regulation and Hypertension

Cited by 41

IL-6 Mediated Transcriptional Programming of Naïve CD4+ T Cells in Early Rheumatoid Arthritis Drives Dysregulated Effector Function

Ridgley, L. A., Anderson, A. E., Maney, N. J., Naamane, N., Skelton, A. J., Lawson, C. A., Emery, P., Isaacs, J. D., Carmody, R. J., & Pratt, A. G. (2019) · Frontiers in Immunology

Rheumatoid Arthritis Research and TherapiesCytokine Signaling Pathways and Interactions

Cited by 27