Frailty and the role of inflammation, immunosenescence and cellular ageing in the very old: Cross-sectional findings from the Newcastle 85+ Study

Frailty in Older Adults: Evidence for a Phenotype

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A standard procedure for creating a frailty index

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Frailty in relation to the accumulation of deficits

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Association between telomere length in blood and mortality in people aged 60 years or older

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Research Agenda for Frailty in Older Adults: Toward a Better Understanding of Physiology and Etiology: Summary from the American Geriatrics Society/National Institute on Aging Research Conference on Frailty in Older Adults

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A comparison of two approaches to measuring frailty in elderly people

Rockwood, K., Andrew, M., & Mitnitski, A. (2007) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/62.7.738 · Cited by 1,291 · see citing works

Phenotype of frailty: characterization in the women's health and aging studies

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Searching for an Operational Definition of Frailty: A Delphi Method Based Consensus Statement. The Frailty Operative Definition-Consensus Conference Project

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World population ageing, 1950-2050

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Frailty: An Emerging Research and Clinical Paradigm--Issues and Controversies

Bergman, H., Ferrucci, L., Guralnik, J., Hogan, D. B., Hummel, S., Karunananthan, S., & Wolfson, C. (2007) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/62.7.731 · Cited by 1,134 · see citing works

The I.A.N.A. task force on frailty assessment of older people in clinical practice

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Prevalence of Frailty in Middle-Aged and Older Community-Dwelling Europeans Living in 10 Countries

Santos-Eggimann, B., Cuenoud, P., Spagnoli, J., & Junod, J. (2009) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/glp012 · Cited by 963 · see citing works

Frailty and Activation of the Inflammation and Coagulation Systems With and Without Clinical Comorbidities<subtitle>Results From the Cardiovascular Health Study</subtitle>

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An integrated view of oxidative stress in aging: basic mechanisms, functional effects, and pathological considerations

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Frailty and Risk of Falls, Fracture, and Mortality in Older Women: The Study of Osteoporotic Fractures

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The Identification of Frailty: A Systematic Literature Review

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Aging, frailty and age-related diseases

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Dynamics of stability: the physiologic basis of functional health and frailty

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Changes in relative fitness and frailty across the adult lifespan: evidence from the Canadian National Population Health Survey

Rockwood, K. J., Song, X., & Mitnitski, A. (2011) · Canadian Medical Association Journal · doi:10.1503/cmaj.101271 · Cited by 573 · see citing works

A Conceptual Framework of Frailty: A Review

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Relative fitness and frailty of elderly men and women in developed countries and their relationship with mortality

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Nonlinear multisystem physiological dysregulation associated with frailty in older women: implications for etiology and treatment

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A Guide to the Standardized Mini-Mental State Examination

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Frailty in Older Men: Prevalence, Progression, and Relationship with Mortality

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Long‐Term Risks of Death and Institutionalization of Elderly People in Relation to Deficit Accumulation at Age 70

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Insulin Resistance and Inflammation as Precursors of Frailty: The Cardiovascular Health Study

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B‐cell diversity decreases in old age and is correlated with poor health status

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Inflammation and frailty in older women

Leng, S. X., Xue, Q., Tian, J., Walston, J. D., & Fried, L. P. (2007) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2007.01186.x · Cited by 425 · see citing works

. HIV-1 infection is associated with an earlier occurrence of a phenotype related to frailty.

Desquilbet, L., Jacobson, L. P., Fried, L. P., Phair, J. P., Jamieson, B. D., Holloway, M., Margolick, J. B., & Study, F. T. M. A. C. (2007) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/62.11.1279 · Cited by 420 · see citing works

Molecular Pathways in Virus-Induced Cytokine Production

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Models, Definitions, and Criteria of Frailty

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An Immune Risk Phenotype, Cognitive Impairment, and Survival in Very Late Life: Impact of Allostatic Load in Swedish Octogenarian and Nonagenarian Humans

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Telomeres as Biomarkers for Ageing and Age-Related Diseases

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Inflammation and frailty measures in older people

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Frailty Among Community-Dwelling Elderly People in France: The Three-City Study

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Serum interleukin-6 and hemoglobin as physiological correlates in the geriatric syndrome of frailty: a pilot study

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Health and disease in 85 year olds: baseline findings from the Newcastle 85+ cohort study

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Immune Parameters in a Longitudinal Study of a Very Old Population of Swedish People: A Comparison Between Survivors and Nonsurvivors

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Changes in CD8 and CD4 lymphocyte subsets, T cell proliferation responses and non-survival in the very old: the Swedish longitudinal OCTO-immune study

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A systematic look at an old problem

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Inflammation markers predicting frailty and mortality in the elderly

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Cytomegalovirus and human immunosenescence

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Aging of the Immune System as a Prognostic Factor for Human Longevity

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Endocrine and inflammatory markers as predictors of frailty

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Telomere length in white blood cells is not associated with morbidity or mortality in the oldest old: a population‐based study

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Comparing models of frailty: the Health and Retirement Study

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Serum levels of insulin-like growth factor-I (IGF-I) and dehydroepiandrosterone sulfate (DHEA-S), and their relationships with serum interleukin-6, in the geriatric syndrome of frailty

Leng, S. X., Cappola, A. R., Andersen, R. E., Blackman, M. R., Koenig, K., Blair, M., & Walston, J. D. (2004) · Aging Clinical and Experimental Research · doi:10.1007/bf03324545 · Cited by 270 · see citing works

Cytomegalovirus Infection and the Risk of Mortality and Frailty in Older Women: A Prospective Observational Cohort Study

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The immune risk profile is associated with age and gender: findings from three Swedish population studies of individuals 20–100 years of age

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No Association Between Telomere Length and Survival Among the Elderly and Oldest Old

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Chronic Cytomegalovirus Infection and Inflammation Are Associated with Prevalent Frailty in Community‐Dwelling Older Women

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Biomarkers of human immunosenescence: impact of cytomegalovirus infection

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A model for reactivation of CMV from latency

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Allostatic Load and Frailty in Older Adults

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The Association of Alanine Transaminase With Aging, Frailty, and Mortality

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Vitamin D deficiency and frailty in older Americans

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Lower Plasma Vitamin E Levels Are Associated With the Frailty Syndrome: The InCHIANTI Study

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Association of Low Vitamin D Levels With the Frailty Syndrome in Men and Women

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The Newcastle 85+ study: biological, clinical and psychosocial factors associated with healthy ageing: study protocol

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Associations of neutrophil and monocyte counts with frailty in community-dwelling disabled older women: Results from the Women’s Health and Aging Studies I

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Systems biology of ageing and longevity

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Multiple Hormonal Deficiencies in Anabolic Hormones Are Found in Frail Older Women: The Women's Health and Aging Studies

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High Oxidative Stress Is Correlated with Frailty in Elderly Chinese

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Association between inflammatory-related disease burden and frailty: Results from the Women's Health and Aging Studies (WHAS) I and II

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Assessment of a large panel of candidate biomarkers of ageing in the Newcastle 85+ study

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Nutrition, Inflammation, and Leptin Levels in Aging and Frailty

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IL-6-independent association of elevated serum neopterin levels with prevalent frailty in community-dwelling older adults

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White Blood Cell Counts, Insulinlike Growth Factor-1 Levels, and Frailty in Community-Dwelling Older Women

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Changes in Reproductive Hormone Concentrations Predict the Prevalence and Progression of the Frailty Syndrome in Older Men: The Concord Health and Ageing in Men Project

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Inflammation and Thrombosis Biomarkers and Incident Frailty in Postmenopausal Women

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T cell subsets and mortality in older community-dwelling women

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Frailty Syndrome is Associated with Altered Circulating Redox Balance and Increased Markers of Oxidative Stress

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Oxidative stress modulation and T cell activation

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Decreased cell proliferation and altered cytokine production in frail older adults

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Engaging the oldest old in research: lessons from the Newcastle 85+ study

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Is Hyperglycemia Associated with Frailty Status in Older Women?

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Cumulative Index of Health Deficiencies as a Characteristic of Long Life

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Telomeres and frailty

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Measuring Systemic Inflammatory Regulation in Older Adults: Evidence and Utility

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Patterns of Comorbid Inflammatory Diseases in Frail Older Women: The Women's Health and Aging Studies I and II

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Allostatic Load and Frailty in the Women's Health and Aging Studies

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T‐Lymphocytes Expressing CC Chemokine Receptor‐5 Are Increased in Frail Older Adults

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The SHARE frailty instrument for primary care predicts incident disability in a European population-based sample.

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Human Cytomegalovirus Reactivation in Bone-Marrow-Derived Granulocyte/Monocyte Progenitor Cells and Mature Monocytes

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CRP 1846G>A polymorphism increases risk of frailty

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Dissociating Markers of Senescence and Protective Ability in Memory T Cells

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Role of Chronic Cytomegalovirus Infection in T‐Cell Immunosenescence and Frailty: More Questions than Answers

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Frailty in elderly people

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Cognitive frailty: Rational and definition from an (I.A.N.A./I.A.G.G.) International Consensus Group

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Inflammation and frailty in the elderly: A systematic review and meta-analysis

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Frailty syndrome: an overview

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Chronic inflammation induces telomere dysfunction and accelerates ageing in mice

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Frailty and sarcopenia: The potential role of an aged immune system

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Towards frailty biomarkers: Candidates from genes and pathways regulated in aging and age-related diseases

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Interleukin-6 and C-reactive protein, successful aging, and mortality: the PolSenior study

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Aging of mice is associated with p16(Ink4a)- and β-galactosidase-positive macrophage accumulation that can be induced in young mice by senescent cells

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New horizons in multimorbidity in older adults

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Phosphoinositide 3-kinase inhibition restores neutrophil accuracy in the elderly: toward targeted treatments for immunosenescence

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No evidence that frailty modifies the positive impact of antihypertensive treatment in very elderly people: an investigation of the impact of frailty upon treatment effect in the HYpertension in the Very Elderly Trial (HYVET) study, a double-blind, placebo-controlled study of antihypertensives in people with hypertension aged 80 and over

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Interconnections between Inflammageing and Immunosenescence during Ageing

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Chronic Kidney Disease: A Clinical Model of Premature Aging

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Age-related frailty and its association with biological markers of ageing

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Standard laboratory tests to identify older adults at increased risk of death

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Emergency General Surgery in the Elderly: Too Old or Too Frail?

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The relationship between depression and frailty syndrome: a systematic review

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Markers of oxidant stress that are clinically relevant in aging and age-related disease

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Oleuropein, a Bioactive Compound from Olea europaea L., as a Potential Preventive and Therapeutic Agent in Non-Communicable Diseases

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A frailty index from common clinical and laboratory tests predicts increased risk of death across the life course

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Epidemiology of Frailty in Older People

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Age-related deficit accumulation and the diseases of ageing

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Inflammatory markers and incident frailty in men and women: the English Longitudinal Study of Ageing

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Systolic Blood Pressure Trajectory, Frailty, and All-Cause Mortality >80 Years of Age

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Association of inflammatory mediators with frailty status in older adults: results from a systematic review and meta-analysis

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Influence of omega-3 fatty acids on skeletal muscle protein metabolism and mitochondrial bioenergetics in older adults

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Biomarkers of oxidative stress are associated with frailty: the Framingham Offspring Study

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Cognitive aspects of frailty: Mechanisms behind the link between frailty and cognitive impairment

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Cellular Senescence and the Biology of Aging, Disease, and Frailty

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Neutrophils in aging and aging‐related pathologies

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Premature Physiologic Aging as a Paradigm for Understanding Increased Risk of Adverse Health Across the Lifespan of Survivors of Childhood Cancer

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A frailty index based on laboratory deficits in community-dwelling men predicted their risk of adverse health outcomes

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Frailty in People Aging With Human Immunodeficiency Virus (HIV) Infection

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Frailty, Inflammatory Markers, and Waitlist Mortality Among Patients With End-stage Renal Disease in a Prospective Cohort Study

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Influence of Aging and Environment on Presentation of Infection in Older Adults

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Altered immune system in frailty: Genetics and diet may influence inflammation

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C-Reactive Protein and Frailty in the Elderly: A Literature Review

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Conceptual Models of Frailty: Accumulation of Deficits

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Inflammatory biomarkers of frailty

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The neutrophil: constant defender and first responder

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Circulating levels of monocyte chemoattractant protein‐1 as a potential measure of biological age in mice and frailty in humans

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Screening for frailty in Canada’s health care system: A time for action

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The aging-related risk signature in colorectal cancer

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Frailty, Inflammation and Immunosenescence

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A Frailty Index Based on Common Laboratory Tests in Comparison With a Clinical Frailty Index for Older Adults in Long-Term Care Facilities

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Physiologic Frailty and Fragility Fracture in HIV-Infected Male Veterans

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Frailty in Older Adults Is Associated With Plasma Concentrations of Inflammatory Mediators but Not With Lymphocyte Subpopulations

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Chronic Low-grade Inflammatory Phenotype (CLIP) and Senescent Immune Dysregulation

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A limit to frailty in very old, community-dwelling people: a secondary analysis of the Chinese longitudinal health and longevity study

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Reduced intestinal motility, mucosal barrier function, and inflammation in aged monkeys

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Association between Oxidative Stress and Frailty in an Elderly German Population: Results from the ESTHER Cohort Study

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HSC Aging and Senescent Immune Remodeling

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The Biology of Aging and Cancer

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Inflammaging markers characteristic of advanced age show similar levels with frailty and dependency

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Development of a frailty index for older people with intellectual disabilities: Results from the HA-ID study

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Frailty biomarkers in humans and rodents: Current approaches and future advances

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A Frailty Index predicts 10-year fracture risk in adults age 25 years and older: results from the Canadian Multicentre Osteoporosis Study (CaMos)

Kennedy, C. C., Ioannidis, G., Rockwood, K. J., Thabane, L., Adachi, J. D., Kirkland, S., Pickard, L. E., & Παπαϊωάννου, Α. (2014) · Osteoporosis International · doi:10.1007/s00198-014-2828-9 · Cited by 101 · see citing works

Inflammatory and immune markers associated with physical frailty syndrome: findings from Singapore longitudinal aging studies

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A new mouse model of frailty: the Cu/Zn superoxide dismutase knockout mouse

Deepa, S. S., Bhaskaran, S., Espinoza, S. E., Brooks, S. V., McArdle, A., Jackson, M. J., Remmen, H. V., & Richardson, A. G. (2017) · GeroScience · doi:10.1007/s11357-017-9975-9 · Cited by 97 · see citing works

Frailty and Risk of Cardiovascular Diseases in Older Persons: The Age, Gene/Environment Susceptibility-Reykjavik Study

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Effect of 24-month physical activity on cognitive frailty and the role of inflammation: the LIFE randomized clinical trial

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Fostering healthy aging: The interdependency of infections, immunity and frailty

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Frailty, Inflammation, and Mortality Among Persons Aging With HIV Infection and Injection Drug Use

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Biological Processes and Biomarkers Related to Frailty in Older Adults: A State-of-the-Science Literature Review

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Bed rest and accelerated aging in relation to the musculoskeletal and cardiovascular systems and frailty biomarkers: A review

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Prehabilitation for the Frailty Syndrome: Improving Outcomes for Our Most Vulnerable Patients

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The Frailty Syndrome: Clinical measurements and basic underpinnings in humans and animals

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Frailty in Rheumatic Diseases

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Clinical features of prefrail older individuals and emerging peripheral biomarkers: A systematic review

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Self‐Reported Hearing Impairment and Incident Frailty in English Community‐Dwelling Older Adults: A 4‐Year Follow‐Up Study

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New horizons in frailty: ageing and the deficit-scaling problem

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Abnormal glucose tolerance, white blood cell count, and telomere length in newly diagnosed, antidepressant-naive patients with depression

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