MacLaren, Robert E.

Subretinal delivery of adeno-associated virus serotype 2 results in minimal immune responses that allow repeat vector administration in immunocompetent mice

Barker, S. E., Broderick, C. A., Robbie, S. J., Duran, Y., Natkunarajah, M., Buch, P., Balaggan, K. S., MacLaren, R. E., Bainbridge, J. W. B., Smith, A. J., et al. (2009) · The Journal of Gene Medicine

Virus-based gene therapy researchRetinal Development and Disorders

Cited by 59

Subretinal timrepigene emparvovec in adult men with choroideremia: a randomized phase 3 trial

MacLaren, R. E., Fischer, M. D., Gow, J. A., Lam, B. L., Sankila, E.-M. K., Girach, A., Panda, S., Yoon, D., Zhao, G., & Pennesi, M. E. (2023) · Nature Medicine

Retinal Development and DisordersVirus-based gene therapy research

Cited by 58

Assessment of Tropism and Effectiveness of New Primate-Derived Hybrid Recombinant AAV Serotypes in the Mouse and Primate Retina

Charbel Issa, P., De Silva, S. R., Lipinski, D. M., Singh, M. S., Mouravlev, A., You, Q., Barnard, A. R., Hankins, M. W., During, M. J., & MacLaren, R. E. (2013) · PLoS ONE

Virus-based gene therapy researchRetinal Development and Disorders

Cited by 53

Enhancement of adeno-associated virus-mediated gene therapy using hydroxychloroquine in murine and human tissues

Chandler, L. C., Barnard, A. R., Caddy, S. L., Patrício, M. I., McClements, M. E., Fu, H., Rada, C., MacLaren, R. E., & Xue, K. (2019) · Molecular Therapy - Methods & Clinical Development

Virus-based gene therapy researchRetinal Development and Disorders

Cited by 50

Therapy Approaches for Stargardt Disease

Piotter, E., McClements, M. E., & MacLaren, R. E. (2021) · Biomolecules

Retinal Development and DisordersRetinal Diseases and Treatments

Cited by 49

Immunomodulatory Effects of Hydroxychloroquine and Chloroquine in Viral Infections and Their Potential Application in Retinal Gene Therapy

Chandler, L., Yusuf, I., McClements, M., Barnard, A., MacLaren, R., & Xue, K. (2020) · International Journal of Molecular Sciences

Virus-based gene therapy researchDrug-Induced Ocular Toxicity

Cited by 49

Characterizing the cellular immune response to subretinal AAV gene therapy in the murine retina

Chandler, L. C., McClements, M. E., Yusuf, I. H., Martinez-Fernandez de la Camara, C., MacLaren, R. E., & Xue, K. (2021) · Molecular Therapy - Methods & Clinical Development

Virus-based gene therapy researchRetinal Development and Disorders

Cited by 43

De Novo Truncating Mutations in WASF1 Cause Intellectual Disability with Seizures

Ito, Y., Carss, K. J., Duarte, S. T., Hartley, T., Keren, B., Kurian, M. A., Marey, I., Charles, P., Mendonça, C., Nava, C., et al. (2018) · The American Journal of Human Genetics

Genetics and Neurodevelopmental DisordersGenomics and Rare Diseases

Cited by 41

Genome-editing strategies for treating human retinal degenerations

Quinn, J., Musa, A., Kantor, A., McClements, M. E., Cehajic-Kapetanovic, J., MacLaren, R. E., & Xue, K. (2021) · Human Gene Therapy

Retinal Development and DisordersCRISPR and Genetic Engineering

Cited by 41

Non-viral delivery of CRISPR/Cas cargo to the retina using nanoparticles: current possibilities, challenges, and limitations

Salman, A., Kantor, A., McClements, M. E., Marfany, G., Trigueros, S., & MacLaren, R. E. (2022) · Pharmaceutics

RNA Interference and Gene DeliveryAdvanced Drug Delivery Systems

Cited by 37

Tropism of AAV Vectors in Photoreceptor-Like Cells of Human iPSC-Derived Retinal Organoids

McClements, M. E., Steward, H., Atkin, W., Goode, E. A., Gándara, C., Chichagova, V., & MacLaren, R. E. (2022) · Translational Vision Science & Technology

Virus-based gene therapy researchRetinal Development and Disorders

Cited by 36

Single-cell transcriptomic analysis of retinal immune regulation and blood-retinal barrier function during experimental autoimmune uveitis

Quinn, J., Salman, A., Paluch, C., Jackson-Wood, M., McClements, M. E., Luo, J., Davis, S. J., Cornall, R. J., MacLaren, R. E., Dendrou, C. A., et al. (2024) · Scientific Reports

Ocular Diseases and Behçet’s SyndromeGlaucoma and retinal disorders

Cited by 32

Vesicular stomatitis virus glycoprotein- and Venezuelan equine encephalitis virus-derived glycoprotein-pseudotyped lentivirus vectors differentially transduce corneal endothelium, trabecular meshwork, and human photoreceptors

Lipinski, D. M., Barnard, A. R., Issa, P. C., Singh, M. S., De Silva, S. R., Trabalza, A., Eleftheriadou, I., Ellison, S. M., Mazarakis, N. D., & MacLaren, R. E. (2014) · Human Gene Therapy

Virus-based gene therapy researchRetinal Development and Disorders

Cited by 24

Robot-assisted retinal surgery: overcoming human limitations

Xue, K., Edwards, T. L., Meenink, H. C. M., Beelen, M. J., Naus, G. J. L., Simunovic, M. P., de Smet, M. D., & MacLaren, R. E. (2019) · Retina Atlas

Retinal and Macular SurgeryIntraocular Surgery and Lenses

Cited by 18

Assessment of AAV Dual Vector Safety in the Abca4−/− Mouse Model of Stargardt Disease

McClements, M. E., Barnard, A. R., Charbel Issa, P., & MacLaren, R. E. (2020) · Translational Vision Science & Technology

Retinal Development and DisordersVirus-based gene therapy research

Cited by 18

Comparison of CRISPR-Cas13b RNA base editing approaches for USH2A-associated inherited retinal degeneration

Fry, L. E., Major, L., Salman, A., McDermott, L. A., Yang, J., King, A. J., McClements, M. E., & MacLaren, R. E. (2025) · Communications Biology

CRISPR and Genetic EngineeringRetinal Development and Disorders

Cited by 15

An open-label phase II study assessing the safety of bilateral, sequential administration of retinal gene therapy in participants with choroideremia: the GEMINI study

MacLaren, R. E., Audo, I., Fischer, M. D., Huckfeldt, R. M., Lam, B. L., Pennesi, M. E., Sisk, R., Gow, J. A., Li, J., Zhu, K., et al. (2024) · Human Gene Therapy

Retinal Development and DisordersVirus-based gene therapy research

Cited by 15

Mouse Slc9a8 Mutants Exhibit Retinal Defects Due to Retinal Pigmented Epithelium Dysfunction

Jadeja, S., Barnard, A. R., McKie, L., Cross, S. H., White, J. K., Robertson, M., Budd, P. S., MacLaren, R. E., & Jackson, I. J. (2015) · Investigative Opthalmology & Visual Science

Retinal Development and DisordersRetinal Diseases and Treatments

Cited by 13

A Fragmented Adeno-Associated Viral Dual Vector Strategy for Treatment of Diseases Caused by Mutations in Large Genes Leads to Expression of Hybrid Transcripts

McClements, M. E., Charbel Issa, P., Blouin, V., & MacLaren, R. E. (2016) · Journal of Genetic Syndromes & Gene Therapy

Virus-based gene therapy researchRNA Interference and Gene Delivery

Cited by 13

Correcting visual loss by genetics and prosthetics

Xue, K., & MacLaren, R. E. (2020) · Current Opinion in Physiology

Retinal Development and DisordersRetinal Diseases and Treatments

Cited by 5

Enhancement of adeno-associated virus-mediated gene therapy using hydroxychloroquine in murine and human tissues

Chandler, L. C., Barnard, A. R., Caddy, S. L., Patrício, M. I., McClements, M. E., Fu, H., Rada, C., MacLaren, R. E., & Xue, K. (2023) · Molecular Therapy - Methods & Clinical Development

Virus-based gene therapy researchRNA Interference and Gene Delivery

Cited by 2