Gaj, Thomas

ZFN, TALEN, and CRISPR/Cas-based methods for genome engineering

Gaj, T., Gersbach, C. A., & Barbas, C. F. (2013) · Trends in Biotechnology

CRISPR and Genetic EngineeringRNA regulation and disease

Cited by 3,820

Targeted gene knockout by direct delivery of zinc-finger nuclease proteins

Gaj, T., Guo, J., Kato, Y., Sirk, S. J., & Barbas, C. F. (2012) · Nature Methods

CRISPR and Genetic EngineeringRNA Interference and Gene Delivery

Cited by 306

Directed evolution of an enhanced and highly efficient FokI cleavage domain for zinc finger nucleases

Guo, J., Gaj, T., & Barbas, C. F. (2010) · Journal of Molecular Biology

CRISPR and Genetic EngineeringRNA Interference and Gene Delivery

Cited by 206

In vivo genome editing improves motor function and extends survival in a mouse model of ALS

Gaj, T., Ojala, D. S., Ekman, F. K., Byrne, L. C., Limsirichai, P., & Schaffer, D. V. (2017) · Science Advances

Amyotrophic Lateral Sclerosis ResearchCRISPR and Genetic Engineering

Cited by 185

Targeted gene knock-in by homology-directed genome editing using Cas9 ribonucleoprotein and AAV donor delivery

Gaj, T., Staahl, B. T., Rodrigues, G. M. C., Limsirichai, P., Ekman, F. K., Doudna, J. A., & Schaffer, D. V. (2017) · Nucleic Acids Research

CRISPR and Genetic EngineeringVirus-based gene therapy research

Cited by 89