Kumar, Sandeep R.P.

Cas9-specific immune responses compromise local and systemic AAV CRISPR therapy in multiple dystrophic canine models

Hakim, C. H., Kumar, S. R. P., Pérez-López, D. O., Wasala, N. B., Zhang, D., Yue, Y., Teixeira, J., Pan, X., Zhang, K., Million, E. D., et al. (2021) · Nature Communications

Virus-based gene therapy researchCRISPR and Genetic Engineering

Cited by 175

Plasmacytoid and conventional dendritic cells cooperate in crosspriming AAV capsid-specific CD8+ T cells

Rogers, G. L., Shirley, J. L., Zolotukhin, I., Kumar, S. R. P., Sherman, A., Perrin, G. Q., Hoffman, B. E., Srivastava, A., Basner-Tschakarjan, E., Wallet, M. A., et al. (2017) · Blood

Immunotherapy and Immune ResponsesVirus-based gene therapy research

Cited by 131

The Balance between CD8(+) T Cell-Mediated Clearance of AAV-Encoded Antigen in the Liver and Tolerance Is Dependent on the Vector Dose

Kumar, S. R. P., Hoffman, B. E., Terhorst, C., de Jong, Y. P., & Herzog, R. W. (2017) · Molecular Therapy

Virus-based gene therapy researchImmunotherapy and Immune Responses

Cited by 83

Effect of CpG Depletion of Vector Genome on CD8+ T Cell Responses in AAV Gene Therapy

Bertolini, T. B., Shirley, J. L., Zolotukhin, I., Li, X., Kaisho, T., Xiao, W., Kumar, S. R. P., & Herzog, R. W. (2021) · Frontiers in Immunology

Virus-based gene therapy researchImmunotherapy and Immune Responses

Cited by 80

Synergy between rapamycin and FLT3 ligand enhances plasmacytoid dendritic cell-dependent induction of CD4+CD25+FoxP3+ Treg

Biswas, M., Sarkar, D., Kumar, S. R. P., Nayak, S., Rogers, G. L., Markusic, D. M., Liao, G., Terhorst, C., & Herzog, R. W. (2015) · Blood

T-cell and B-cell ImmunologyImmunotherapy and Immune Responses

Cited by 70

Innate immune sensing of adeno-associated virus vectors

Cao, D., Byrne, B. J., de Jong, Y. P., Terhorst, C., Duan, D., Herzog, R. W., & Kumar, S. R. P. (2024) · Human Gene Therapy

Virus-based gene therapy researchImmunotherapy and Immune Responses

Cited by 50

Gene therapy with regulatory T cells: A beneficial alliance

Biswas, M., Kumar, S. R. P., Terhorst, C., & Herzog, R. W. (2018) · Frontiers in Immunology

Virus-based gene therapy researchT-cell and B-cell Immunology

Cited by 41

IL-15 blockade and rapamycin rescue multifactorial loss of factor VIII from AAV-transduced hepatocytes in hemophilia A mice

Butterfield, J. S. S., Yamada, K., Bertolini, T. B., Syed, F., Kumar, S. R. P., Li, X., Arisa, S., Piñeros, A. R., Tapia, A., Rogers, C. A., et al. (2022) · Molecular Therapy

Hemophilia Treatment and ResearchVirus-based gene therapy research

Cited by 36

TLR9-Activating CpG-B ODN but Not TLR7 Agonists Triggers Antibody Formation to Factor IX in Muscle Gene Transfer

Butterfield, J. S. S., Biswas, M., Shirley, J. L., Kumar, S. R. P., Sherman, A., Terhorst, C., Ling, C., & Herzog, R. W. (2019) · Human Gene Therapy Methods

Immunotherapy and Immune ResponsesVirus-based gene therapy research

Cited by 35

TLR9-independent CD8+ T cell responses in hepatic AAV gene transfer through IL-1R1-MyD88 signaling

Kumar, S. R. P., Biswas, M., Cao, D., Arisa, S., Muñoz-Melero, M., Lam, A. K., Piñeros, A. R., Kapur, R., Kaisho, T., Kaufman, R. J., et al. (2024) · Molecular Therapy

Virus-based gene therapy researchImmunotherapy and Immune Responses

Cited by 31

Immune Responses to Muscle-Directed Adeno-Associated Viral Gene Transfer in Clinical Studies

Kumar, S. R. P., Duan, D., & Herzog, R. W. (2023) · Human Gene Therapy

Virus-based gene therapy researchRNA Interference and Gene Delivery

Cited by 28

B cell depletion eliminates FVIII memory b cells and enhances AAV8-coF8 immune tolerance induction when combined with rapamycin

Biswas, M., Palaschak, B., Kumar, S. R. P., Rana, J., & Markusic, D. M. (2020) · Frontiers in Immunology

Hemophilia Treatment and ResearchVirus-based gene therapy research

Cited by 28

B cell focused transient immune suppression protocol for efficient AAV readministration to the liver

Rana, J., Herzog, R. W., Muñoz-Melero, M., Yamada, K., Kumar, S. R. P., Lam, A. K., Markusic, D. M., Duan, D., Terhorst, C., Byrne, B. J., et al. (2024) · Molecular Therapy - Methods & Clinical Development

Virus-based gene therapy researchRNA Interference and Gene Delivery

Cited by 26