Shearn, Colin T.

4-hydroxynonenal inhibits SIRT3 via thiol-specific modification

Fritz, K. S., Galligan, J. J., Smathers, R. L., Roede, J. R., Shearn, C. T., Reigan, P., & Petersen, D. R. (2011) · Chemical Research in Toxicology

Sirtuins and Resveratrol in MedicineRedox biology and oxidative stress

Cited by 127

Increased carbonylation of the lipid phosphatase PTEN contributes to Akt2 activation in a murine model of early alcohol-induced steatosis

Shearn, C. T., Smathers, R. L., Backos, D. S., Reigan, P., Orlicky, D. J., & Petersen, D. R. (2013) · Free Radical Biology and Medicine

Alcohol Consumption and Health EffectsLiver Disease Diagnosis and Treatment

Cited by 69

Characterization of 4-HNE Modified L-FABP Reveals Alterations in Structural and Functional Dynamics

Smathers, R. L., Fritz, K. S., Galligan, J. J., Shearn, C. T., Reigan, P., Marks, M. J., & Petersen, D. R. (2012) · PLoS ONE

Protein Interaction Studies and Fluorescence AnalysisAntioxidant Activity and Oxidative Stress

Cited by 61

Phosphatase and tensin homolog deleted on chromosome 10 (PTEN) signaling regulates mitochondrial biogenesis and respiration via estrogen-related receptor α (ERRα)

Li, Y., He, L., Zeng, N., Sahu, D., Cadenas, E., Shearn, C., Li, W., & Stiles, B. L. (2013) · Journal of Biological Chemistry

Metabolism, Diabetes, and CancerMitochondrial Function and Pathology

Cited by 58

Identification of 5′ AMP-activated Kinase as a Target of Reactive Aldehydes during Chronic Ingestion of High Concentrations of Ethanol

Shearn, C. T., Backos, D. S., Orlicky, D. J., Smathers-McCullough, R. L., & Petersen, D. R. (2014) · Journal of Biological Chemistry

Alcohol Consumption and Health EffectsMetabolism, Diabetes, and Cancer

Cited by 57

Oxidative stress-mediated aldehyde adduction of GRP78 in a mouse model of alcoholic liver disease: functional independence of ATPase activity and chaperone function

Galligan, J. J., Fritz, K. S., Backos, D. S., Shearn, C. T., Smathers, R. L., Jiang, H., MacLean, K. N., Reigan, P. R., & Petersen, D. R. (2014) · Free Radical Biology and Medicine

Endoplasmic Reticulum Stress and DiseaseHeat shock proteins research

Cited by 46

Inhibition of Hydrogen peroxide signaling by 4-hydroxynonenal due to differential regulation of Akt1 and Akt2 contributes to decreases in cell survival and proliferation in hepatocellular carcinoma cells

Shearn, C. T., Reigan, P., & Petersen, D. R. (2012) · Free Radical Biology and Medicine

Redox biology and oxidative stressPI3K/AKT/mTOR signaling in cancer

Cited by 42

Increased 4-hydroxynonenal protein adducts in male GSTA4–4/PPAR-α double knockout mice enhance injury during early stages of alcoholic liver disease

Ronis, M. J. J., Mercer, K. E., Gannon, B., Engi, B., Zimniak, P., Shearn, C. T., Orlicky, D. J., Albano, E., Badger, T. M., & Petersen, D. R. (2015) · American Journal of Physiology-Gastrointestinal and Liver Physiology

Alcohol Consumption and Health EffectsLiver physiology and pathology

Cited by 27

Increased hepatocellular protein carbonylation in human end-stage alcoholic cirrhosis

Shearn, C. T., Orlicky, D. J., Saba, L. M., Shearn, A. H., & Petersen, D. R. (2015) · Free Radical Biology and Medicine

Alcohol Consumption and Health EffectsAntioxidant Activity and Oxidative Stress

Cited by 19

4-Hydroxy-2-nonenal attenuates 8-oxoguanine DNA glycosylase 1 activity

Pan, G., Deshpande, M., Pang, H., Stemmer, P. M., Carruthers, N. J., Shearn, C. T., Backos, D. S., & Palaniyandi, S. S. (2020) · Journal of Cellular Biochemistry

DNA Repair MechanismsRedox biology and oxidative stress

Cited by 16