Zeviani, Massimo

Human mitochondrial DNA deletions associated with mutations in the gene encoding twinkle, a phage T7 gene 4-like protein localized in mitochondria

Spelbrink, J. N., Li, F.-Y., Tiranti, V., Nikali, K., Yuan, Q.-P., Tariq, M., Wanrooij, S., Garrido, N., Comi, G., Morandi, L., et al. (2001) · Nature Genetics

Mitochondrial Function and PathologyDNA Repair Mechanisms

Cited by 882

Oxygen sensing requires mitochondrial ROS but not oxidative phosphorylation

Brunelle, J. K., Bell, E. L., Quesada, N. M., Vercauteren, K., Tiranti, V., Zeviani, M., Scarpulla, R. C., & Chandel, N. S. (2005) · Cell Metabolism

Cancer, Hypoxia, and MetabolismRedox biology and oxidative stress

Cited by 763

The Opa1-Dependent Mitochondrial Cristae Remodeling Pathway Controls Atrophic, Apoptotic, and Ischemic Tissue Damage

Varanita, T., Soriano, M. E., Romanello, V., Zaglia, T., Quintana-Cabrera, R., Semenzato, M., Menabò, R., Costa, V., Civiletto, G., Pesce, P., et al. (2015) · Cell Metabolism

Mitochondrial Function and PathologyCell death mechanisms and regulation

Cited by 460

MPV17 encodes an inner mitochondrial membrane protein and is mutated in infantile hepatic mitochondrial DNA depletion

Spinazzola, A., Viscomi, C., Fernandez-Vizarra, E., Carrara, F., D'Adamo, P., Calvo, S., Marsano, R. M., Donnini, C., Weiher, H., Strisciuglio, P., et al. (2006) · Nature Genetics

Mitochondrial Function and PathologyMetabolism and Genetic Disorders

Cited by 427

NAD+-Dependent Activation of Sirt1 Corrects the Phenotype in a Mouse Model of Mitochondrial Disease

Cerutti, R., Pirinen, E., Lamperti, C., Marchet, S., Sauve, A. A., Li, W., Leoni, V., Schon, E. A., Dantzer, F., Auwerx, J., et al. (2014) · Cell Metabolism

Sirtuins and Resveratrol in MedicineMitochondrial Function and Pathology

Cited by 343

Transcription Factor EB Controls Metabolic Flexibility during Exercise

Mansueto, G., Armani, A., Viscomi, C., D’Orsi, L., De Cegli, R., Polishchuk, E. V., Lamperti, C., Di Meo, I., Romanello, V., Marchet, S., et al. (2017) · Cell Metabolism

Metabolism, Diabetes, and CancerAutophagy in Disease and Therapy

Cited by 314

Increased longevity and refractoriness to Ca2+-dependent neurodegeneration in Surf1 knockout mice

Dell'Agnello, C., Leo, S., Agostino, A., Szabadkai, G., Tiveron, C., Zulian, A., Prelle, A., Roubertoux, P., Rizzuto, R., & Zeviani, M. (2007) · Human Molecular Genetics

Mitochondrial Function and PathologyMetabolism and Genetic Disorders

Cited by 308

Mutations of mitochondrial DNA polymerase γA are a frequent cause of autosomal dominant or recessive progressive external ophthalmoplegia

Lamantea, E., Tiranti, V., Bordoni, A., Toscano, A., Bono, F., Servidei, S., Papadimitriou, A., Spelbrink, H., Silvestri, L., Casari, G., et al. (2002) · Annals of Neurology

Mitochondrial Function and PathologyHereditary Neurological Disorders

Cited by 270

Clinical and molecular findings in children with complex I deficiency

Bugiani, M., Invernizzi, F., Alberio, S., Briem, E., Lamantea, E., Carrara, F., Moroni, I., Farina, L., Spada, M., Donati, M. A., et al. (2004) · Biochimica et Biophysica Acta (BBA) - Bioenergetics

Mitochondrial Function and PathologyMetabolism and Genetic Disorders

Cited by 264

Neural stem cells traffic functional mitochondria via extracellular vesicles

Peruzzotti-Jametti, L., Bernstock, J. D., Willis, C. M., Manferrari, G., Rogall, R., Fernandez-Vizarra, E., Williamson, J. C., Braga, A., van den Bosch, A., Leonardi, T., et al. (2021) · PLOS Biology

Extracellular vesicles in diseaseMesenchymal stem cell research

Cited by 263

Pharmacological Inhibition of poly(ADP-ribose) polymerases improves fitness and mitochondrial function in skeletal muscle

Pirinen, E., Cantó, C., Jo, Y. S., Morato, L., Zhang, H., Menzies, K. J., Williams, E. G., Mouchiroud, L., Moullan, N., Hagberg, C., et al. (2014) · Cell Metabolism

Mitochondrial Function and PathologyMetabolism, Diabetes, and Cancer

Cited by 254

FGF21 is a biomarker for mitochondrial translation and mtDNA maintenance disorders

Lehtonen, J. M., Forsström, S., Bottani, E., Viscomi, C., Baris, O. R., Isoniemi, H., Höckerstedt, K., Österlund, P., Hurme, M., Jylhävä, J., et al. (2016) · Neurology

Mitochondrial Function and PathologyFibroblast Growth Factor Research

Cited by 220

Opa1 Overexpression Ameliorates the Phenotype of Two Mitochondrial Disease Mouse Models

Civiletto, G., Varanita, T., Cerutti, R., Gorletta, T., Barbaro, S., Marchet, S., Lamperti, C., Viscomi, C., Scorrano, L., & Zeviani, M. (2015) · Cell Metabolism

Mitochondrial Function and PathologyMetabolism and Genetic Disorders

Cited by 216

Assembly of the oxidative phosphorylation system in humans: What we have learned by studying its defects

Fernández-Vizarra, E., Tiranti, V., & Zeviani, M. (2009) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research

Mitochondrial Function and PathologyATP Synthase and ATPases Research

Cited by 214

Loss of function of the mitochondrial peptidase PITRM1 induces proteotoxic stress and Alzheimer’s disease-like pathology in human cerebral organoids

Ivanyuk, D., Pérez, M. J., Panagiotakopoulou, V., Di Napoli, G., Brunetti, D., Al-Shaana, R., Kaeser, S. A., Jucker, M., Zeviani, M., Viscomi, C., et al. (2020) · Molecular Psychiatry

Alzheimer's disease research and treatmentsMitochondrial Function and Pathology

Cited by 145

Structure-function defects of human mitochondrial DNA polymerase in autosomal dominant progressive external ophthalmoplegia

Graziewicz, M. A., Longley, M. J., Bienstock, R. J., Zeviani, M., & Copeland, W. C. (2004) · Nature Structural & Molecular Biology

Mitochondrial Function and PathologyDNA Repair Mechanisms

Cited by 131

Early-onset liver mtDNA depletion and late-onset proteinuric nephropathy in Mpv17 knockout mice

Viscomi, C., Spinazzola, A., Maggioni, M., Fernandez-Vizarra, E., Massa, V., Pagano, C., Vettor, R., Mora, M., & Zeviani, M. (2009) · Human Molecular Genetics

Mitochondrial Function and PathologyMetabolism and Genetic Disorders

Cited by 102

Dysregulated mitophagy and mitochondrial organization in optic atrophy due to OPA1 mutations

Liao, C., Ashley, N., Diot, A., Morten, K., Phadwal, K., Williams, A., Fearnley, I., Rosser, L., Lowndes, J., Fratter, C., et al. (2017) · Neurology

Autophagy in Disease and TherapyMitochondrial Function and Pathology

Cited by 97

POLG1 in idiopathic Parkinson disease

Tiangyou, W., Hudson, G., Ghezzi, D., Ferrari, G., Zeviani, M., Burn, D. J., & Chinnery, P. F. (2006) · Neurology

Parkinson's Disease Mechanisms and TreatmentsDeep Brain Stimulation and Movement Disorders

Cited by 50

OPA1 mutations and mitochondrial DNA damage: keeping the magic circle in shape

Zeviani, M. (2008) · Brain

Mitochondrial Function and PathologyAutophagy in Disease and Therapy

Cited by 41