Smolders, Joost

Tissue-resident memory T cells populate the human brain

Smolders, J., Heutinck, K. M., Fransen, N. L., Remmerswaal, E. B. M., Hombrink, P., ten Berge, I. J. M., van Lier, R. A. W., Huitinga, I., & Hamann, J. (2018) · Nature Communications

T-cell and B-cell ImmunologyNeuroinflammation and Neurodegeneration Mechanisms

Cited by 406

Locus for severity implicates CNS resilience in progression of multiple sclerosis

International Multiple Sclerosis Genetics Consortium, Harroud, A., Stridh, P., McCauley, J. L., Saarela, J., van den Bosch, A. M. R., Engelenburg, H. J., Beecham, A. H., Alfredsson, L., Alikhani, K., et al. (2023) · Nature

Multiple Sclerosis Research StudiesGenetic Associations and Epidemiology

Cited by 243

Phenotyping primary human microglia: tight regulation of LPS responsiveness

Melief, J., Koning, N., Schuurman, K. G., Van De Garde, M. D. B., Smolders, J., Hoek, R. M., Van Eijk, M., Hamann, J., & Huitinga, I. (2012) · Glia

Neuroinflammation and Neurodegeneration MechanismsInflammasome and immune disorders

Cited by 146

GPCRomics of homeostatic and disease-associated human microglia

Hsiao, C.-C., Sankowski, R., Prinz, M., Smolders, J., Huitinga, I., & Hamann, J. (2021) · Frontiers in Immunology

Neuroinflammation and Neurodegeneration MechanismsReceptor Mechanisms and Signaling

Cited by 59

Neurofilament Light Chain Levels in Multiple Sclerosis Correlate With Lesions Containing Foamy Macrophages and With Acute Axonal Damage

van den Bosch, A., Fransen, N., Mason, M., Rozemuller, A. J., Teunissen, C., Smolders, J., & Huitinga, I. (2022) · Neurology Neuroimmunology & Neuroinflammation

Multiple Sclerosis Research StudiesNeuroinflammation and Neurodegeneration Mechanisms

Cited by 58

Selective emergence of antibody-secreting cells in the multiple sclerosis brain

Bogers, L., Engelenburg, H. J., Janssen, M., Unger, P.-P. A., Melief, M.-J., Wierenga-Wolf, A. F., Hsiao, C.-C., Mason, M. R. J., Hamann, J., van Langelaar, J., et al. (2023) · eBioMedicine

Multiple Sclerosis Research StudiesT-cell and B-cell Immunology

Cited by 40

Post‐mortem multiple sclerosis lesion pathology is influenced by single nucleotide polymorphisms

Fransen, N. L., Crusius, J. B. A., Smolders, J., Mizee, M. R., van Eden, C. G., Luchetti, S., Remmerswaal, E. B. M., Hamann, J., Mason, M. R. J., & Huitinga, I. (2020) · Brain Pathology

Multiple Sclerosis Research StudiesPsoriasis: Treatment and Pathogenesis

Cited by 37

Stress-Axis Regulation by Vitamin D3 in Multiple Sclerosis

Rolf, L., Damoiseaux, J., Huitinga, I., Kimenai, D., van den Ouweland, J., Hupperts, R., & Smolders, J. (2018) · Frontiers in Neurology

Vitamin D Research StudiesMultiple Sclerosis Research Studies

Cited by 28

Distinct transcriptional changes distinguish efficient and poor remyelination in multiple sclerosis

Chen, J. Q. A., McNamara, N. B., Engelenburg, H. J., Jongejan, A., Wever, D. D., Hopman, K., van Rixel, E., Nijhuis, P. J. H., de Winter, F., Moerland, P. D., et al. (2025) · Brain

Multiple Sclerosis Research StudiesNeuroinflammation and Neurodegeneration Mechanisms

Cited by 17

Inflammatory microglia correlate with impaired oligodendrocyte maturation in multiple sclerosis

Chen, J. Q. A., Wever, D. D., McNamara, N. B., Bourik, M., Smolders, J., Hamann, J., & Huitinga, I. (2025) · Frontiers in Immunology

Multiple Sclerosis Research StudiesNeuroinflammation and Neurodegeneration Mechanisms

Cited by 9

Microglial states associate with lesion dynamics in multiple sclerosis

van den Bosch, A. M. R., Khoo, J. H., Lu, Z., Liang, H., Wever, D., Pu, L., Eggen, B. J. L., Uhlén, M., Smolders, J., Hamann, J., et al. (2026) · Cell Reports

Multiple Sclerosis Research StudiesNeuroinflammation and Neurodegeneration Mechanisms

Cited by 6