Porritt, Michelle J.

Can Animal Models of Disease Reliably Inform Human Studies?

van der Worp, H. B., Howells, D. W., Sena, E. S., Porritt, M. J., Rewell, S., O'Collins, V., & Macleod, M. R. (2010) · PLoS Medicine

Animal testing and alternativesBiomedical Ethics and Regulation

Cited by 1,354

Reduced BDNF mRNA Expression in the Parkinson's Disease Substantia Nigra

Howells, D. W., Porritt, M. J., Wong, J. Y. F., Batchelor, P. E., Kalnins, R., Hughes, A. J., & Donnan, G. A. (2000) · Experimental Neurology

Parkinson's Disease Mechanisms and TreatmentsNerve injury and regeneration

Cited by 513

Unbiased detection of CRISPR off-targets in vivo using DISCOVER-Seq

Wienert, B., Wyman, S. K., Richardson, C. D., Yeh, C. D., Akcakaya, P., Porritt, M. J., Morlock, M., Vu, J. T., Kazane, K. R., Watry, H. L., et al. (2019) · Science

CRISPR and Genetic EngineeringRNA regulation and disease

Cited by 434

Different Strokes for Different Folks: The Rich Diversity of Animal Models of Focal Cerebral Ischemia

Howells, D. W., Porritt, M. J., Rewell, S. S., O'Collins, V., Sena, E. S., van der Worp, H. B., Traystman, R. J., & Macleod, M. R. (2010) · Journal of Cerebral Blood Flow & Metabolism

Acute Ischemic Stroke ManagementNeurological Disease Mechanisms and Treatments

Cited by 309

Inhibiting BDNF expression by antisense oligonucleotide infusion causes loss of nigral dopaminergic neurons

Porritt, M. J., Batchelor, P. E., & Howells, D. W. (2005) · Experimental Neurology

Parkinson's Disease Mechanisms and TreatmentsNuclear Receptors and Signaling

Cited by 135

IDOL regulates systemic energy balance through control of neuronal VLDLR expression

Lee, S. D., Priest, C., Bjursell, M., Gao, J., Arneson, D. V., Ahn, I. S., Diamante, G., van Veen, J. E., Massa, M. G., Calkin, A. C., et al. (2019) · Nature Metabolism

Regulation of Appetite and ObesityCholesterol and Lipid Metabolism

Cited by 26