Pagani, Alessia

The Serine Protease Matriptase-2 (TMPRSS6) Inhibits Hepcidin Activation by Cleaving Membrane Hemojuvelin

Silvestri, L., Pagani, A., Nai, A., De Domenico, I., Kaplan, J., & Camaschella, C. (2008) · Cell Metabolism

Iron Metabolism and DisordersFerroptosis and cancer prognosis

Cited by 555

Furin-mediated release of soluble hemojuvelin: a new link between hypoxia and iron homeostasis

Silvestri, L., Pagani, A., & Camaschella, C. (2008) · Blood

Iron Metabolism and DisordersErythropoietin and Anemia Treatment

Cited by 311

Deletion of TMPRSS6 attenuates the phenotype in a mouse model of β-thalassemia

Nai, A., Pagani, A., Mandelli, G., Lidonnici, M. R., Silvestri, L., Ferrari, G., & Camaschella, C. (2012) · Blood

Iron Metabolism and DisordersHemoglobinopathies and Related Disorders

Cited by 161

The second transferrin receptor regulates red blood cell production in mice

Nai, A., Lidonnici, M. R., Rausa, M., Mandelli, G., Pagani, A., Silvestri, L., Ferrari, G., & Camaschella, C. (2015) · Blood

Iron Metabolism and DisordersErythropoietin and Anemia Treatment

Cited by 156

Low hepcidin accounts for the proinflammatory status associated with iron deficiency

Pagani, A., Nai, A., Corna, G., Bosurgi, L., Rovere-Querini, P., Camaschella, C., & Silvestri, L. (2011) · Blood

Iron Metabolism and DisordersFerroptosis and cancer prognosis

Cited by 138

TMPRSS6 rs855791 modulates hepcidin transcription in vitro and serum hepcidin levels in normal individuals

Nai, A., Pagani, A., Silvestri, L., Campostrini, N., Corbella, M., Girelli, D., Traglia, M., Toniolo, D., & Camaschella, C. (2011) · Blood

Iron Metabolism and DisordersNeurological diseases and metabolism

Cited by 113

Defective targeting of hemojuvelin to plasma membrane is a common pathogenetic mechanism in juvenile hemochromatosis

Silvestri, L., Pagani, A., Fazi, C., Gerardi, G., Levi, S., Arosio, P., & Camaschella, C. (2007) · Blood

Iron Metabolism and DisordersNeurological diseases and metabolism

Cited by 84

The immunophilin FKBP12 inhibits hepcidin expression by binding the BMP type I receptor ALK2 in hepatocytes

Colucci, S., Pagani, A., Pettinato, M., Artuso, I., Nai, A., Camaschella, C., & Silvestri, L. (2017) · Blood

Iron Metabolism and DisordersTGF-β signaling in diseases

Cited by 62

A Strong Anti-Inflammatory Signature Revealed by Liver Transcription Profiling of Tmprss6-/- Mice

Riba, M., Rausa, M., Sorosina, M., Cittaro, D., Garcia Manteiga, J. M., Nai, A., Pagani, A., Martinelli-Boneschi, F., Stupka, E., Camaschella, C., et al. (2013) · PLoS ONE

Iron Metabolism and DisordersFerroptosis and cancer prognosis

Cited by 23