The second transferrin receptor regulates red blood cell production in mice
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Key Points: TFR2, a gene mutated in hemochromatosis and a partner of the EPO receptor, limits erythropoiesis expansion in mice. Iron deficiency mimics TFR2 deletion in the erythroid compartment.
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Loss of bone marrow TFR2 in mice increases the sensitivity of erythroblasts to erythropoietin, causing erythrocytosis, especially in iron deficiency.
“Loss of bone marrow TFR2 in mice increases the sensitivity of erythroblasts to erythropoietin, which causes erythrocytosis, especially in iron deficiency.68”
From Iron metabolism and iron disorders revisited in the hepcidin era (2020) · cites this paper as [68]
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Cites
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A Red carpet for iron metabolism
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“Loss of bone marrow TFR2 in mice increases the sensitivity of erythroblasts to erythropoietin, which causes erythrocytosis, especially in iron deficiency.(68) Liver TFR2 upregulates hepcidin and TFR2mutations cause hemochromatosis.”
Self-citationCamaschella, C. (2019) · Blood · doi:10.1182/blood-2018-05-815944 · Cited by 702 · see citing works
Self-citationThe Polygenic and Monogenic Basis of Blood Traits and Diseases
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NCOA4 deficiency impairs systemic iron homeostasis
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Self-citationIneffective erythropoiesis and regulation of iron status in iron loading anaemias
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- Authors
- Nai, A., Lidonnici, M. R., Rausa, M., Mandelli, G., Pagani, A., Silvestri, L., Ferrari, G., & Camaschella, C.
- Affiliations
- Vita-Salute San Raffaele University (IT)
- The San Raffaele Telethon Institute for Gene Therapy (IT)
- ORCID
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2015-02-12
- Volume
- 125
- Issue
- 7
- Pages
- 1170-1179
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- PMC
- PMC4399753
- OpenAlex
- W2026199006
- Cited by
- 156
- References
- 2
- Citations by year
- 2026: 4 · 2025: 7 · 2024: 10 · 2023: 15 · 2022: 7 · 2021: 11 · 2020: 25 · 2019: 13 · 2018: 16 · 2017: 20 · 2016: 12 · 2015: 15
- FWCI
- 11.11
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Blood (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Archivio Istituzionale della Ricerca - Università Vita-Salute San Raffaele (submittedVersion)
- Funders
- Ministero dell’Istruzione, dell’Università e della Ricerca (2010-2011)
- Topics
- Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
- Health Sciences › Medicine › Hematology › Erythropoietin and Anemia Treatment
- Health Sciences › Medicine › Genetics › Hemoglobinopathies and Related Disorders
- Keywords
- transferrin receptor 2, erythropoiesis, erythroblasts, erythropoietin, hepcidin, erythroferrone, iron deficiency, iron sensing, Bcl-xL, erythropoietin receptor
- MeSH terms
- Animals, Erythrocyte Count, Erythrocytes, Erythropoiesis, Erythropoietin, Female, Hemoglobins, Iron, Male, Mice, Inbred C57BL, Receptors, Transferrin, Apoptosis, Mice, Knockout, Mice, Hepcidins
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