Kirschner, Kristina

SC3: consensus clustering of single-cell RNA-seq data

Kiselev, V. Y., Kirschner, K., Schaub, M. T., Andrews, T., Yiu, A., Chandra, T., Natarajan, K. N., Reik, W., Barahona, M., Green, A. R., et al. (2017) · Nature Methods

Single-cell and spatial transcriptomicsGene expression and cancer classification

Cited by 1,500

Autophagy mediates the mitotic senescence transition

Young, A. R. J., Narita, M., Ferreira, M., Kirschner, K., Sadaie, M., Darot, J. F. J., Tavaré, S., Arakawa, S., Shimizu, S., Watt, F. M., et al. (2009) · Genes & Development

Autophagy in Disease and TherapyTelomeres, Telomerase, and Senescence

Cited by 1,078

Distinct synovial tissue macrophage subsets regulate inflammation and remission in rheumatoid arthritis

Alivernini, S., MacDonald, L., Elmesmari, A., Finlay, S., Tolusso, B., Gigante, M. R., Petricca, L., Di Mario, C., Bui, L., Perniola, S., et al. (2020) · Nature Medicine

Rheumatoid Arthritis Research and TherapiesImmune cells in cancer

Cited by 740

Global reorganization of the nuclear landscape in senescent cells

Chandra, T., Ewels, P. A., Schoenfelder, S., Furlan-Magaril, M., Wingett, S. W., Kirschner, K., Thuret, J.-Y., Andrews, S., Fraser, P., & Reik, W. (2015) · Cell Reports

Genomics and Chromatin DynamicsNuclear Structure and Function

Cited by 348

Independence of Repressive Histone Marks and Chromatin Compaction during Senescent Heterochromatic Layer Formation

Chandra, T., Kirschner, K., Thuret, J.-Y., Pope, B. D., Ryba, T., Newman, S., Ahmed, K., Samarajiwa, S. A., Salama, R., Carroll, T., et al. (2012) · Molecular Cell

Genomics and Chromatin DynamicsEpigenetics and DNA Methylation

Cited by 308

NOTUM from Apc-mutant cells biases clonal competition to initiate cancer

Flanagan, D. J., Pentinmikko, N., Luopajärvi, K., Willis, N. J., Gilroy, K., Raven, A. P., Mcgarry, L., Englund, J. I., Webb, A. T., Scharaw, S., et al. (2021) · Nature

Wnt/β-catenin signaling in development and cancerGenetic factors in colorectal cancer

Cited by 255

Notch Signaling Mediates Secondary Senescence

Teo, Y. V., Rattanavirotkul, N., Olova, N., Salzano, A., Quintanilla, A., Tarrats, N., Kiourtis, C., Müller, M., Green, A. R., Adams, P. D., et al. (2019) · Cell Reports

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 149

Longitudinal dynamics of clonal hematopoiesis identifies gene-specific fitness effects

Robertson, N. A., Latorre-Crespo, E., Terradas-Terradas, M., Lemos-Portela, J., Purcell, A. C., Livesey, B. J., Hillary, R. F., Murphy, L., Fawkes, A., MacGillivray, L., et al. (2022) · Nature Medicine

Acute Myeloid Leukemia ResearchCancer Genomics and Diagnostics

Cited by 132

Single-cell analysis of senescent epithelia reveals targetable mechanisms promoting fibrosis

O’Sullivan, E. D., Mylonas, K. J., Bell, R., Carvalho, C., Baird, D. P., Cairns, C., Gallagher, K. M., Campbell, R., Docherty, M., Laird, A., et al. (2022) · JCI Insight

Telomeres, Telomerase, and SenescenceAcute Kidney Injury Research

Cited by 43

Locus-specific induction of gene expression from heterochromatin loci during cellular senescence

Tomimatsu, K., Bihary, D., Olan, I., Parry, A. J., Schoenfelder, S., Chan, A. S. L., Slater, G. S. C., Ito, Y., Rugg-Gunn, P. J., Kirschner, K., et al. (2021) · Nature Aging

Genomics and Chromatin DynamicsTelomeres, Telomerase, and Senescence

Cited by 25

Promises of reprogramming-induced rejuvenation

Simpson, D. J., Arif, N., Suwanlikit, Y., Kirschner, K., & Chandra, T. (2026) · Current Opinion in Genetics & Development

Pluripotent Stem Cells ResearchTelomeres, Telomerase, and Senescence

Cited by 2