Hinton, David R.

DICER1 deficit induces Alu RNA toxicity in age-related macular degeneration

Kaneko, H., Dridi, S., Tarallo, V., Gelfand, B. D., Fowler, B. J., Cho, W. G., Kleinman, M. E., Ponicsan, S. L., Hauswirth, W. W., Chiodo, V. A., et al. (2011) · Nature

Retinal Diseases and TreatmentsRetinal Development and Disorders

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DICER1 loss and Alu RNA induce age-related macular degeneration via the NLRP3 inflammasome and MyD88

Tarallo, V., Hirano, Y., Gelfand, B. D., Dridi, S., Kerur, N., Kim, Y., Cho, W. G., Kaneko, H., Fowler, B. J., Bogdanovich, S., et al. (2012) · Cell

Inflammasome and immune disordersRetinal Diseases and Treatments

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A protocol for the culture and differentiation of highly polarized human retinal pigment epithelial cells

Sonoda, S., Spee, C., Barron, E., Ryan, S. J., Kannan, R., & Hinton, D. R. (2009) · Nature Protocols

Retinal Diseases and TreatmentsRetinal Development and Disorders

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Identification of early pericyte loss and vascular amyloidosis in Alzheimer’s disease retina

Shi, H., Koronyo, Y., Rentsendorj, A., Regis, G. C., Sheyn, J., Fuchs, D.-T., Kramerov, A. A., Ljubimov, A. V., Dumitrascu, O. M., Rodriguez, A. R., et al. (2020) · Acta Neuropathologica

Barrier Structure and Function StudiesAlzheimer's disease research and treatments

Cited by 230

Nucleoside reverse transcriptase inhibitors possess intrinsic anti-inflammatory activity

Fowler, B. J., Gelfand, B. D., Kim, Y., Kerur, N., Tarallo, V., Hirano, Y., Amarnath, S., Fowler, D. H., Radwan, M., Young, M. T., et al. (2014) · Science

Inflammasome and immune disordersAdenosine and Purinergic Signaling

Cited by 225

Toll-like Receptor 3 and Geographic Atrophy in Age-Related Macular Degeneration

Yang, Z., Stratton, C., Francis, P. J., Kleinman, M. E., Tan, P. L., Gibbs, D., Tong, Z., Chen, H., Constantine, R., Yang, X., et al. (2008) · New England Journal of Medicine

Retinal Diseases and TreatmentsRetinal Development and Disorders

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The mitochondrial-Derived peptide humanin protects RPE cells from oxidative stress, senescence, and mitochondrial dysfunction

Sreekumar, P. G., Ishikawa, K., Spee, C., Mehta, H. H., Wan, J., Yen, K., Cohen, P., Kannan, R., & Hinton, D. R. (2016) · Investigative Opthalmology & Visual Science

Retinal Diseases and TreatmentsMitochondrial Function and Pathology

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ERK1/2 activation is a therapeutic target in age-related macular degeneration

Dridi, S., Hirano, Y., Tarallo, V., Kim, Y., Fowler, B. J., Ambati, B. K., Bogdanovich, S., Chiodo, V. A., Hauswirth, W. W., Kugel, J. F., et al. (2012) · Proceedings of the National Academy of Sciences

Retinal Diseases and TreatmentsRetinal Development and Disorders

Cited by 105

Cytoplasmic synthesis of endogenous Alu complementary DNA via reverse transcription and implications in age-related macular degeneration

Fukuda, S., Varshney, A., Fowler, B. J., Wang, S.-B., Narendran, S., Ambati, K., Yasuma, T., Magagnoli, J., Leung, H., Hirahara, S., et al. (2021) · Proceedings of the National Academy of Sciences

Chromosomal and Genetic VariationsRetinal Diseases and Treatments

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