Hollfelder, Florian

The role of protein dynamics in the evolution of new enzyme function

Campbell, E., Kaltenbach, M., Correy, G. J., Carr, P. D., Porebski, B. T., Livingstone, E. K., Afriat-Jurnou, L., Buckle, A. M., Weik, M., Hollfelder, F., et al. (2016) · Nature Chemical Biology

Protein Structure and DynamicsEnzyme Catalysis and Immobilization

Cited by 311

Dynamic cell contacts between periportal mesenchyme and ductal epithelium act as a rheostat for liver cell proliferation

Cordero-Espinoza, L., Dowbaj, A. M., Kohler, T. N., Strauss, B., Sarlidou, O., Belenguer, G., Pacini, C., Martins, N. P., Dobie, R., Wilson-Kanamori, J. R., et al. (2021) · Cell Stem Cell

Liver physiology and pathologyTissue Engineering and Regenerative Medicine

Cited by 74

Ultrahigh-throughput directed evolution of a metal-free α/β-hydrolase with a Cys-His-Asp triad into an efficient phosphotriesterase

Schnettler Fernández, D., Klein, O. J., Kaminski, T. S., Colin, P.-Y., & Hollfelder, F. (2022) · Journal of the American Chemical Society

Enzyme Catalysis and ImmobilizationEnzyme Production and Characterization

Cited by 47

Ultrahigh-Throughput Directed Evolution of a Metal-Free α/β-Hydrolase with a Cys-His-Asp Triad into an Efficient Phosphotriesterase

Schnettler, J. D., Klein, O. J., Kaminski, T. S., Colin, P.-Y., & Hollfelder, F. (2023) · Journal of the American Chemical Society

Enzyme Catalysis and ImmobilizationEnzyme Production and Characterization

Cited by 47

High-Throughput Steady-State Enzyme Kinetics Measured in a Parallel Droplet Generation and Absorbance Detection Platform

Neun, S., van Vliet, L., Hollfelder, F., & Gielen, F. (2022) · Analytical Chemistry

Innovative Microfluidic and Catalytic Techniques InnovationMicrofluidic and Capillary Electrophoresis Applications

Cited by 20

Selection of a promiscuous minimalist cAMP phosphodiesterase from a library of de novo designed proteins

Schnettler, J. D., Wang, M. S., Gantz, M., Bunzel, H. A., Karas, C., Hollfelder, F., & Hecht, M. H. (2024) · Nature Chemistry

Enzyme Catalysis and ImmobilizationProtein Structure and Dynamics

Cited by 18

Selection of a Promiscuous Minimalist cAMP Phosphodiesterase from a Library of De Novo Designed Proteins

Schnettler, J. D., Wang, M. S., Gantz, M., Karas, C., Hollfelder, F., & Hecht, M. H. (2023) · Nature Chemistry

Enzyme Catalysis and ImmobilizationProtein Structure and Dynamics

Cited by 18