Taunton, Jack

A SARS-CoV-2 protein interaction map reveals targets for drug repurposing

Gordon, D. E., Jang, G. M., Bouhaddou, M., Xu, J., Obernier, K., White, K. M., O’Meara, M. J., Rezelj, V. V., Guo, J. Z., Swaney, D. L., et al. (2020) · Nature

SARS-CoV-2 and COVID-19 ResearchComputational Drug Discovery Methods

Cited by 4,405

A Mammalian Histone Deacetylase Related to the Yeast Transcriptional Regulator Rpd3p

Taunton, J., Hassig, C. A., & Schreiber, S. L. (1996) · Science

Histone Deacetylase Inhibitors ResearchGenomics and Chromatin Dynamics

Cited by 1,829

The promise and peril of chemical probes

Arrowsmith, C. H., Audia, J. E., Austin, C., Baell, J., Bennett, J., Blagg, J., Bountra, C., Brennan, P. E., Brown, P. J., Bunnage, M. E., et al. (2015) · Nature Chemical Biology

Click Chemistry and ApplicationsComputational Drug Discovery Methods

Cited by 839

Broad-Spectrum Kinase Profiling in Live Cells with Lysine-Targeted Sulfonyl Fluoride Probes

Zhao, Q., Ouyang, X., Wan, X., Gajiwala, K. S., Kath, J. C., Jones, L. H., Burlingame, A. L., & Taunton, J. (2017) · Journal of the American Chemical Society

Click Chemistry and ApplicationsAdvanced Proteomics Techniques and Applications

Cited by 388

Covalent docking of large libraries for the discovery of chemical probes

London, N., Miller, R. M., Krishnan, S., Uchida, K., Irwin, J. J., Eidam, O., Gibold, L., Cimermančič, P., Bonnet, R., Shoichet, B. K., et al. (2014) · Nature Chemical Biology

Computational Drug Discovery MethodsClick Chemistry and Applications

Cited by 274

Total Synthesis and Biological Mode of Action of Largazole: A Potent Class I Histone Deacetylase Inhibitor

Bowers, A., West, N., Taunton, J., Schreiber, S. L., Bradner, J. E., & Williams, R. M. (2008) · Journal of the American Chemical Society

Histone Deacetylase Inhibitors ResearchHeterocyclic Compound Synthesis and Bioactivity

Cited by 165

JAK/STAT pathway inhibition overcomes IL7-induced glucocorticoid resistance in a subset of human T-cell acute lymphoblastic leukemias

Delgado-Martin, C., Meyer, L. K., Huang, B. J., Shimano, K. A., Zinter, M. S., Nguyen, J. V., Smith, G. A., Taunton, J., Winter, S. S., Roderick, J. R., et al. (2017) · Leukemia

Acute Lymphoblastic Leukemia researchAcute Myeloid Leukemia Research

Cited by 133

Chromatin kinases act on transcription factors and histone tails in regulation of inducible transcription

Josefowicz, S. Z., Shimada, M., Armache, A., Li, C. H., Miller, R. M., Lin, S., Yang, A., Dill, B. D., Molina, H., Park, H.-S., et al. (2016) · Molecular Cell

Genomics and Chromatin DynamicsChromatin Remodeling and Cancer

Cited by 84

IFITM proteins assist cellular uptake of diverse linked chemotypes

Lou, K., Wassarman, D. R., Yang, T., Paung, Y., Zhang, Z., O’Loughlin, T. A., Moore, M. K., Egan, R. K., Greninger, P., Benes, C. H., et al. (2022) · Science

Drug Transport and Resistance MechanismsRNA Interference and Gene Delivery

Cited by 42