Emmerson, Paul J.

The metabolic effects of GDF15 are mediated by the orphan receptor GFRAL

Emmerson, P. J., Wang, F., Du, Y., Liu, Q., Pickard, R. T., Gonciarz, M. D., Coskun, T., Hamang, M. J., Sindelar, D. K., Ballman, K. K., et al. (2017) · Nature Medicine

GDF15 and Related BiomarkersRegulation of Appetite and Obesity

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Tirzepatide is an imbalanced and biased dual GIP and GLP-1 receptor agonist

Willard, F. S., Douros, J. D., Gabe, M. B. N., Showalter, A. D., Wainscott, D. B., Suter, T. M., Capozzi, M. E., van der Velden, W. J. C., Stutsman, C., Cardona, G. R., et al. (2020) · JCI Insight

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Discovery, development, and clinical proof of mechanism of LY3463251, a long-acting GDF15 receptor agonist

Benichou, O., Coskun, T., Gonciarz, M. D., Garhyan, P., Adams, A. C., Du, Y., Dunbar, J. D., Martin, J. A., Mather, K. J., Pickard, R. T., et al. (2023) · Cell Metabolism

Regulation of Appetite and ObesityGDF15 and Related Biomarkers

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Galanin receptor-mediated inhibition of glutamate release in the arcuate nucleus of the hypothalamus

Kinney, G. A., Emmerson, P. J., & Miller, R. J. (1998) · The Journal of Neuroscience

Neuropeptides and Animal PhysiologyNeuroscience and Neuropharmacology Research

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Anorectic and aversive effects of GLP-1 receptor agonism are mediated by brainstem cholecystokinin neurons, and modulated by GIP receptor activation

Costa, A., Ai, M., Nunn, N., Culotta, I., Hunter, J., Boudjadja, M. B., Valencia-Torres, L., Aviello, G., Hodson, D. J., Snider, B. M., et al. (2022) · Molecular Metabolism

Regulation of Appetite and ObesityDiabetes Treatment and Management

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The pharmacological basis for nonpeptide agonism of the GLP-1 receptor by orforglipron

Sloop, K. W., Cox, A. L., Wainscott, D. B., White, A., Droz, B. A., Stutsman, C., Showalter, A. D., Suter, T. M., Dunbar, J. D., Snider, B. M., et al. (2024) · Science Translational Medicine

Diabetes Treatment and ManagementReceptor Mechanisms and Signaling

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Beyond Glucagon-like Peptide-1: Is G-Protein Coupled Receptor Polypharmacology the Path Forward to Treating Metabolic Diseases?

Sloop, K. W., Briere, D. A., Emmerson, P. J., & Willard, F. S. (2018) · ACS Pharmacology & Translational Science

Diabetes Treatment and ManagementReceptor Mechanisms and Signaling

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Brainstem BDNF neurons are downstream of GFRAL/GLP1R signalling

Feetham, C. H., Collabolletta, V., Worth, A. A., Shoop, R., Groom, S., Harding, C., Boutagouga Boudjadja, M., Coskun, T., Emmerson, P. J., D’Agostino, G., et al. (2024) · Nature Communications

Regulation of Appetite and ObesityBiochemical Analysis and Sensing Techniques

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