Lee, Francis S.

Molecular Adaptations Underlying Susceptibility and Resistance to Social Defeat in Brain Reward Regions

Krishnan, V., Han, M.-H., Graham, D. L., Berton, O., Renthal, W., Russo, S. J., LaPlant, Q., Graham, A., Lutter, M., Lagace, D. C., et al. (2007) · Cell

Neurotransmitter Receptor Influence on BehaviorStress Responses and Cortisol

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Genetic variant BDNF (Val66Met) polymorphism alters anxiety-related behavior

Chen, Z.-Y., Jing, D., Bath, K. G., Ieraci, A., Khan, T., Siao, C.-J., Herrera, D. G., Toth, M., Yang, C., McEwen, B. S., et al. (2006) · Science

Neurotransmitter Receptor Influence on BehaviorNerve injury and regeneration

Cited by 1,340

ProBDNF Induces Neuronal Apoptosis via Activation of a Receptor Complex of p75NTRand Sortilin

Teng, H. K., Teng, K. K., Lee, R., Wright, S., Tevar, S., Almeida, R. D., Kermani, P., Torkin, R., Chen, Z.-Y., Lee, F. S., et al. (2005) · The Journal of Neuroscience

Nerve injury and regenerationCell death mechanisms and regulation

Cited by 1,013

Rare coding variants in ten genes confer substantial risk for schizophrenia

Singh, T., Poterba, T., Curtis, D., Akil, H., Al Eissa, M., Barchas, J. D., Bass, N., Bigdeli, T. B., Breen, G., Bromet, E. J., et al. (2022) · Nature

Schizophrenia research and treatmentGenetic Associations and Epidemiology

Cited by 983

Variant Brain-Derived Neurotrophic Factor (BDNF) (Met66) Alters the Intracellular Trafficking and Activity-Dependent Secretion of Wild-Type BDNF in Neurosecretory Cells and Cortical Neurons

Chen, Z.-Y., Patel, P. D., Sant, G., Meng, C.-X., Teng, K. K., Hempstead, B. L., & Lee, F. S. (2004) · The Journal of Neuroscience

Nerve injury and regenerationCellular transport and secretion

Cited by 874

A Genetic Variant BDNF Polymorphism Alters Extinction Learning in Both Mouse and Human

Soliman, F., Glatt, C. E., Bath, K. G., Levita, L., Jones, R. M., Pattwell, S. S., Jing, D., Tottenham, N., Amso, D., Somerville, L. H., et al. (2010) · Science

Memory and Neural MechanismsNeurotransmitter Receptor Influence on Behavior

Cited by 585

Adolescent mental health—opportunity and obligation

Lee, F. S., Heimer, H., Giedd, J. N., Lein, E. S., Šestan, N., Weinberger, D. R., & Casey, B. J. (2014) · Science

Child and Adolescent Psychosocial and Emotional DevelopmentNeural and Behavioral Psychology Studies

Cited by 531

Neuronal release of proBDNF

Yang, J., Siao, C.-J., Nagappan, G., Marinic, T., Jing, D., McGrath, K., Chen, Z.-Y., Mark, W., Tessarollo, L., Lee, F. S., et al. (2009) · Nature Neuroscience

Nerve injury and regenerationNeuroscience and Neuropharmacology Research

Cited by 449

DSM-5 and RDoC: progress in psychiatry research?

Casey, B. J., Craddock, N., Cuthbert, B. N., Hyman, S. E., Lee, F. S., & Ressler, K. J. (2013) · Nature Reviews Neuroscience

Mental Health and PsychiatryMental Health Research Topics

Cited by 434

The microbiota regulate neuronal function and fear extinction learning

Chu, C., Murdock, M. H., Jing, D., Won, T. H., Chung, H., Kressel, A. M., Tsaava, T., Addorisio, M. E., Putzel, G. G., Zhou, L., et al. (2019) · Nature

Memory and Neural MechanismsGut microbiota and health

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Altered fear learning across development in both mouse and human

Pattwell, S. S., Duhoux, S., Hartley, C. A., Johnson, D. C., Jing, D., Elliott, M. D., Ruberry, E. J., Powers, A., Mehta, N., Yang, R. R., et al. (2012) · Proceedings of the National Academy of Sciences

Memory and Neural MechanismsNeuroscience and Neuropharmacology Research

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Brain-Derived Neurotrophic Factor Val66Met Allele Impairs Basal and Ketamine-Stimulated Synaptogenesis in Prefrontal Cortex

Liu, R.-J., Lee, F. S., Li, X.-Y., Bambico, F., Duman, R. S., & Aghajanian, G. K. (2012) · Biological Psychiatry

Treatment of Major DepressionNeuroscience and Neuropharmacology Research

Cited by 403

Slitrk5 deficiency impairs corticostriatal circuitry and leads to obsessive-compulsive-like behaviors in mice

Shmelkov, S. V., Hormigo, A., Jing, D., Proenca, C. C., Bath, K. G., Milde, T., Shmelkov, E., Kushner, J. S., Baljevic, M., Dincheva, I., et al. (2010) · Nature Medicine

Obsessive-Compulsive Spectrum DisordersNeurotransmitter Receptor Influence on Behavior

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Towards a youth mental health paradigm: a perspective and roadmap

Uhlhaas, P. J., Davey, C. G., Mehta, U. M., Shah, J., Torous, J., Allen, N. B., Avenevoli, S., Bella-Awusah, T., Chanen, A., Chen, E. Y. H., et al. (2023) · Molecular Psychiatry

Child and Adolescent Psychosocial and Emotional DevelopmentPsychology and Mental Health

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Early-life stress has persistent effects on amygdala function and development in mice and humans

Malter Cohen, M., Jing, D., Yang, R. R., Tottenham, N., Lee, F. S., & Casey, B. J. (2013) · Proceedings of the National Academy of Sciences

Stress Responses and CortisolChild Abuse and Trauma

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FAAH genetic variation enhances fronto-amygdala function in mouse and human

Dincheva, I., Drysdale, A. T., Hartley, C. A., Johnson, D. C., Jing, D., King, E. C., Ra, S., Gray, J. M., Yang, R., DeGruccio, A. M., et al. (2015) · Nature Communications

Cannabis and Cannabinoid ResearchMemory and Neural Mechanisms

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D-Cycloserine Augmentation of Exposure-Based Cognitive Behavior Therapy for Anxiety, Obsessive-Compulsive, and Posttraumatic Stress Disorders: A Systematic Review and Meta-analysis of Individual Participant Data

Mataix-Cols, D., Fernández de la Cruz, L., Monzani, B., Rosenfield, D., Andersson, E., Pérez-Vigil, A., Frumento, P., de Kleine, R. A., Difede, J., Dunlop, B. W., et al. (2017) · JAMA Psychiatry

Anxiety, Depression, Psychometrics, Treatment, Cognitive ProcessesPosttraumatic Stress Disorder Research

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Variant Brain-Derived Neurotrophic Factor Val66Met Polymorphism Alters Vulnerability to Stress and Response to Antidepressants

Yu, H., Wang, D.-D., Wang, Y., Liu, T., Lee, F. S., & Chen, Z.-Y. (2012) · The Journal of Neuroscience

Neurotransmitter Receptor Influence on BehaviorStress Responses and Cortisol

Cited by 275

BDNF and glucocorticoids regulate corticotrophin-releasing hormone (CRH) homeostasis in the hypothalamus

Jeanneteau, F. D., Lambert, W. M., Ismaili, N., Bath, K. G., Lee, F. S., Garabedian, M. J., & Chao, M. V. (2012) · Proceedings of the National Academy of Sciences

Stress Responses and CortisolNeuropeptides and Animal Physiology

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Cannabis and the Developing Brain: Insights into Its Long-Lasting Effects

Hurd, Y. L., Manzoni, O. J., Pletnikov, M. V., Lee, F. S., Bhattacharyya, S., & Melis, M. (2019) · The Journal of Neuroscience

Cannabis and Cannabinoid ResearchPrenatal Substance Exposure Effects

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Val66Met polymorphism of BDNF alters prodomain structure to induce neuronal growth cone retraction

Anastasia, A., Deinhardt, K., Chao, M. V., Will, N. E., Irmady, K., Lee, F. S., Hempstead, B. L., & Bracken, C. (2013) · Nature Communications

Nerve injury and regenerationAxon Guidance and Neuronal Signaling

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D-cycloserine augmentation of exposure therapy for post-traumatic stress disorder: a pilot randomized clinical trial

Difede, J., Cukor, J., Wyka, K., Olden, M., Hoffman, H., Lee, F. S., & Altemus, M. (2014) · Neuropsychopharmacology

Posttraumatic Stress Disorder ResearchMemory and Neural Mechanisms

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Dynamic changes in neural circuitry during adolescence are associated with persistent attenuation of fear memories

Pattwell, S. S., Liston, C., Jing, D., Ninan, I., Yang, R. R., Witztum, J., Murdock, M. H., Dincheva, I., Bath, K. G., Casey, B. J., et al. (2016) · Nature Communications

Memory and Neural MechanismsNeuroscience and Neuropharmacology Research

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BDNF Val66Met impairs fluoxetine-induced enhancement of adult hippocampus plasticity

Bath, K. G., Jing, D. Q., Dincheva, I., Neeb, C. C., Pattwell, S. S., Chao, M. V., Lee, F. S., & Ninan, I. (2012) · Neuropsychopharmacology

Neurotransmitter Receptor Influence on BehaviorNeurogenesis and neuroplasticity mechanisms

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