Zender, Lars

Platelet PD-L1 reflects collective intratumoral PD-L1 expression and predicts immunotherapy response in non-small cell lung cancer

Hinterleitner, C., Strähle, J., Malenke, E., Hinterleitner, M., Henning, M., Seehawer, M., Bilich, T., Heitmann, J., Lutz, M., Mattern, S., et al. (2021) · Nature Communications

Cancer Immunotherapy and BiomarkersT-cell and B-cell Immunology

Cited by 175

Tissue-specific and reversible RNA interference in transgenic mice

Dickins, R. A., McJunkin, K., Hernando, E., Premsrirut, P. K., Krizhanovsky, V., Burgess, D. J., Kim, S. Y., Cordon-Cardo, C., Zender, L., Hannon, G. J., et al. (2007) · Nature Genetics

RNA Interference and Gene DeliveryAnimal Genetics and Reproduction

Cited by 174

A Direct In Vivo RNAi Screen Identifies MKK4 as a Key Regulator of Liver Regeneration

Wuestefeld, T., Pesic, M., Rudalska, R., Dauch, D., Longerich, T., Kang, T.-W., Yevsa, T., Heinzmann, F., Hoenicke, L., Hohmeyer, A., et al. (2013) · Cell

Liver physiology and pathologyTissue Engineering and Regenerative Medicine

Cited by 149

Implications of Cellular Senescence in Tissue Damage Response, Tumor Suppression, and Stem Cell Biology

Krizhanovsky, V., Xue, W., Zender, L., Yon, M., Hernando, E., & Lowe, S. W. (2008) · Cold Spring Harbor Symposia on Quantitative Biology

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 138

OmoMYC blunts promoter invasion by oncogenic MYC to inhibit gene expression characteristic of MYC-dependent tumors

Jung, L. A., Gebhardt, A., Koelmel, W., Ade, C. P., Walz, S., Kuper, J., von Eyss, B., Letschert, S., Redel, C., d'Artista, L., et al. (2017) · Oncogene

Cancer-related Molecular PathwaysGenomics and Chromatin Dynamics

Cited by 101

Cellular senescence in gastrointestinal diseases: from pathogenesis to therapeutics

Frey, N., Venturelli, S., Zender, L., & Bitzer, M. (2018) · Nature Reviews Gastroenterology & Hepatology

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 97

First-in-class MKK4 inhibitors enhance liver regeneration and prevent liver failure

Zwirner, S., Abu Rmilah, A. A., Klotz, S., Pfaffenroth, B., Kloevekorn, P., Moschopoulou, A. A., Schuette, S., Haag, M., Selig, R., Li, K., et al. (2024) · Cell

Liver physiology and pathologyTissue Engineering and Regenerative Medicine

Cited by 65

Telomerase-Dependent Virotherapy Overcomes Resistance of Hepatocellular Carcinomas against Chemotherapy and Tumor Necrosis Factor–Related Apoptosis-Inducing Ligand by Elimination of Mcl-1

Wirth, T., Kühnel, F., Fleischmann-Mundt, B., Woller, N., Djojosubroto, M., Rudolph, K. L., Manns, M., Zender, L., & Kubicka, S. (2005) · Cancer Research

Virus-based gene therapy researchTelomeres, Telomerase, and Senescence

Cited by 65

Design and synthesis of 1H-pyrazolo[3,4-b]pyridines targeting mitogen-activated protein kinase kinase 4 (MKK4) - A promising target for liver regeneration

Pfaffenrot, B., Klövekorn, P., Juchum, M., Selig, R., Albrecht, W., Zender, L., & Laufer, S. A. (2021) · European Journal of Medicinal Chemistry

Heterocyclic Compound Synthesis and BioactivityComputational Drug Discovery Methods

Cited by 26

A Differentiation Checkpoint Limits Hematopoietic Stem Cell Self-Renewal in Response to DNA Damage

Wang, J., Sun, Q., Morita, Y., Jiang, H., Groß, A., Lechel, A., Hildner, K., Guachalla, L. M., Gompf, A., Hartmann, D., et al. (2014) · Cell

Hematopoietic Stem Cell TransplantationDNA Repair Mechanisms

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When AI Joins the Table: Evaluating Large Language Model Performance in Soft Tissue Sarcoma Tumor Board Decisions

Dehdab, R., Afat, S., Mankertz, F., Brendel, J. M., Maalouf, N., Werner, S., Brendlin, A., Herrmann, J., Nikolaou, K., Kloker, L. D., et al. (2026) · Journal of Cancer Research and Clinical Oncology

Artificial Intelligence in Healthcare and EducationAI in cancer detection

Cited by 5